Brain zaps coming off Effexor XR

Posted by valkyrie @valkyrie, Aug 8, 2023

I hope someone can help me. I am experiencing terrible brain zaps coming off of Effexor XR. I have no doubt they have tapered me down to quickly, but now that I’m in the withdrawal, I do not want to go back on it. I have a prescription for Cymbalta which they want me to try but I’m afraid to start it feeling this bad. Has anyone else experienced this? Has anyone used cannabis to help? I have a medical marijuana card. I’m so grateful there are people out there who can understand this.

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Profile picture for frances007 @frances007

I have used the tapering suggestion that was offered by another member, and it has worked well for me. I am currently on 37.5mg, and have been at this dose for quite some time. Over the past few days I tried emptying some of the medication out of the capsule and adding it to my coffee in the morning. I tried this over the course of a few days, and noticed that I was feeling much more tearful than usual. Granted, I have recently undergone a horrible and traumatic experience, and this may be a contributing factor, but the depth of my sorrow was so great that I surprised myself. Is this a common reaction? I will certainly ask my neurologist about this on Wednesday, but wondered if anyone has had a similar response. As a side bar, since tapering off of this drug, I am sleeping better and having less headaches, which is a very good thing. Thank you very much for all of your help.

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When I first read about tapering off Effexor by removing beads from the capsules, I didn't think that was realistic. Apparently, it is one of the recommended methods and I don't know how else to wean off of 37.5 mg, as my previous two attempts were unsuccessful.
https://www.survivingantidepressants.org/topic/272-tips-for-tapering-off-effexor-and-effexor-xr-venlafaxine/
Note that mixing the beads in liquid is tricky.

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Profile picture for frances007 @frances007

I have used the tapering suggestion that was offered by another member, and it has worked well for me. I am currently on 37.5mg, and have been at this dose for quite some time. Over the past few days I tried emptying some of the medication out of the capsule and adding it to my coffee in the morning. I tried this over the course of a few days, and noticed that I was feeling much more tearful than usual. Granted, I have recently undergone a horrible and traumatic experience, and this may be a contributing factor, but the depth of my sorrow was so great that I surprised myself. Is this a common reaction? I will certainly ask my neurologist about this on Wednesday, but wondered if anyone has had a similar response. As a side bar, since tapering off of this drug, I am sleeping better and having less headaches, which is a very good thing. Thank you very much for all of your help.

Jump to this post

I had very good success tapering by measuring beads. Purchased jewelers scale and capsules. Weighed beads in original capsule. Set up schedule by reducing bead weight by 10% each month based on previous month. Doing the same now with Temazepam (powder in capsules). Good luck on your tapering program. You can do it!

REPLY
Profile picture for frances007 @frances007

I have used the tapering suggestion that was offered by another member, and it has worked well for me. I am currently on 37.5mg, and have been at this dose for quite some time. Over the past few days I tried emptying some of the medication out of the capsule and adding it to my coffee in the morning. I tried this over the course of a few days, and noticed that I was feeling much more tearful than usual. Granted, I have recently undergone a horrible and traumatic experience, and this may be a contributing factor, but the depth of my sorrow was so great that I surprised myself. Is this a common reaction? I will certainly ask my neurologist about this on Wednesday, but wondered if anyone has had a similar response. As a side bar, since tapering off of this drug, I am sleeping better and having less headaches, which is a very good thing. Thank you very much for all of your help.

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I learned on survivingantedepressants.org that you have to taper by 10% from each previous dose.
I wish I had known when I weaned off. I just cut down by 12.5mg every 3 weeks. One month after 0mg my current hell started. Debiliating anxiety, panic, anhedonia. Three months into this I reinstated 5 beads (2mg) for a week, and just started 4mg. I'm going to go up until I feel normalish. According to this graph, people do not need to go that high in the dosage to get therapeutic effect as high drug 'occupancy' in your brain is reached well before 37.5mg. I debated going on a Prozac bridge, but that might complicate things. So as upsetting as it is to put this poison in my body again, I have to do it to function. I have two kids and was laid off work a month ago. Really bad timeing. Work helped me stay calm.

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Profile picture for frances007 @frances007

in reply to @ave13 Thank you! I failed to mention the nightmares because I thought they were unrelated, but now that you have shared this information, everything is making sense in terms of the tapering. Young? Well, I suppose at 62 I am young, but I do have a very old soul.
Thanks again

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@kelvinthomas again. I'm 80 but read quite a lot of scientific journals. Don't think my Dr. understands effects of going from 150 to 75. I've either got to go to to an neurologist or just live with the 150. Don't want to go through the agony again. Frances007, you're still young and might want to try again. Horrible nightmares are the the most common side effect.

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Profile picture for frances007 @frances007

I have used the tapering suggestion that was offered by another member, and it has worked well for me. I am currently on 37.5mg, and have been at this dose for quite some time. Over the past few days I tried emptying some of the medication out of the capsule and adding it to my coffee in the morning. I tried this over the course of a few days, and noticed that I was feeling much more tearful than usual. Granted, I have recently undergone a horrible and traumatic experience, and this may be a contributing factor, but the depth of my sorrow was so great that I surprised myself. Is this a common reaction? I will certainly ask my neurologist about this on Wednesday, but wondered if anyone has had a similar response. As a side bar, since tapering off of this drug, I am sleeping better and having less headaches, which is a very good thing. Thank you very much for all of your help.

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in reply to @kelvinthomas Thank you very much. I am working on tapering from 37.5 mg downward. I tried weighing the small "pebbles" inside the capsule on my kitchen scale, but they did not register. My next option will be to add them to a 1/4 teaspoon and try to decrease a little each day. Interestingly enough, I am still having nightmares, even when I went back to the 37.5 mg, ones that I wish I did not remember, as they are so real and relate to the recent horrible experience of a couple of weeks ago. I did discuss all of this with my psychologist who also is a MD, and she cautioned me to go very slowly because this medication is "all time awful." I had no idea that at one time it was pulled from the market, and suppose I should not be surprised that my doctor prescribed it in the first place. I know I no longer have a "chemical imbalance" in terms of my depression, as it is primarily the consequences of living with a chronic, incurable illness, When I tapered from the 150 mg to 112.5 mg I had no serious side effects, just sort of feeling "out of it" for the first week or so. After a few weeks I went down to the 75mg as described on this platform, then finally to the 37.5mg where I am at present. Yes, I am still young, but even still, I feel the relevance of coping with my ever changing physical maladies, if you will. I am still determined to remain strong and active as I possibly can, even if it makes me feel worse on some days. I really wish sometimes I were wired to curl up in a ball and feel what people have called, "immobilized." But I just cannot give in. Doctors understand so little today as it is, and I have found a way to navigate the system to the best of my ability, even if that means going against the advice of my doctor. Thank you for telling me about the nightmares, as I have never experienced such vivid ones in the past that actually wake me up.

REPLY
Profile picture for frances007 @frances007

I have used the tapering suggestion that was offered by another member, and it has worked well for me. I am currently on 37.5mg, and have been at this dose for quite some time. Over the past few days I tried emptying some of the medication out of the capsule and adding it to my coffee in the morning. I tried this over the course of a few days, and noticed that I was feeling much more tearful than usual. Granted, I have recently undergone a horrible and traumatic experience, and this may be a contributing factor, but the depth of my sorrow was so great that I surprised myself. Is this a common reaction? I will certainly ask my neurologist about this on Wednesday, but wondered if anyone has had a similar response. As a side bar, since tapering off of this drug, I am sleeping better and having less headaches, which is a very good thing. Thank you very much for all of your help.

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All these comments are so helpful. Tapering down from 75 mg Effexor to 37.5 was no big deal. Then the simply dreadful nightmares started, and I couldn't get through my day. I'm not young (76) but I'm determined to get off this poison and have a better life with the years I have left. Thanks for the info on the jeweller's scale, the teaspoon and 10%. Such a help.

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Profile picture for frances007 @frances007

in reply to @kelvinthomas Thank you very much. I am working on tapering from 37.5 mg downward. I tried weighing the small "pebbles" inside the capsule on my kitchen scale, but they did not register. My next option will be to add them to a 1/4 teaspoon and try to decrease a little each day. Interestingly enough, I am still having nightmares, even when I went back to the 37.5 mg, ones that I wish I did not remember, as they are so real and relate to the recent horrible experience of a couple of weeks ago. I did discuss all of this with my psychologist who also is a MD, and she cautioned me to go very slowly because this medication is "all time awful." I had no idea that at one time it was pulled from the market, and suppose I should not be surprised that my doctor prescribed it in the first place. I know I no longer have a "chemical imbalance" in terms of my depression, as it is primarily the consequences of living with a chronic, incurable illness, When I tapered from the 150 mg to 112.5 mg I had no serious side effects, just sort of feeling "out of it" for the first week or so. After a few weeks I went down to the 75mg as described on this platform, then finally to the 37.5mg where I am at present. Yes, I am still young, but even still, I feel the relevance of coping with my ever changing physical maladies, if you will. I am still determined to remain strong and active as I possibly can, even if it makes me feel worse on some days. I really wish sometimes I were wired to curl up in a ball and feel what people have called, "immobilized." But I just cannot give in. Doctors understand so little today as it is, and I have found a way to navigate the system to the best of my ability, even if that means going against the advice of my doctor. Thank you for telling me about the nightmares, as I have never experienced such vivid ones in the past that actually wake me up.

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Weighing did not work for me either. I found it worked well to open capsule and remove and throw away 2 white pebbles/spansules out of each capsule for the next month.
After that month take out 4 white pebbles from each capsule for the next 30or 60 days.
Then when you feel level and adjusted. Take out 5 out of each for next month and so on and so on. It takes many months to wean down but it’s better than experiencing the withdrawal symptoms. Have patience.

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Profile picture for sassysaveur @sassysaveur

Weighing did not work for me either. I found it worked well to open capsule and remove and throw away 2 white pebbles/spansules out of each capsule for the next month.
After that month take out 4 white pebbles from each capsule for the next 30or 60 days.
Then when you feel level and adjusted. Take out 5 out of each for next month and so on and so on. It takes many months to wean down but it’s better than experiencing the withdrawal symptoms. Have patience.

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If you look at the research, you are decreasing the dose in the wrong direction. One should start by removing more beads in the beginning (no more than ten percent) and reduce by fewer and fewer beads over time. If you think about it, this makes sense because removing more and more beads would mean you are decreasing the dosage by a larger percentage of the drug, which is not what you want to do. See this link for a better explanation:

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Profile picture for njoys @njoys

If you look at the research, you are decreasing the dose in the wrong direction. One should start by removing more beads in the beginning (no more than ten percent) and reduce by fewer and fewer beads over time. If you think about it, this makes sense because removing more and more beads would mean you are decreasing the dosage by a larger percentage of the drug, which is not what you want to do. See this link for a better explanation:

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in reply to @sassysaveur Thank you! I appreciate this information very much. Those beads are so tiny, that removing them feels like I am back in the chemistry lab in college. I will move ahead as you have suggested, as I really want to get off of this medication. I do not need it and do not want to take it going forward. After the discussion with my psychologist, who is also a MD, I am even more determined to remove this medication from my already spilling over medicine cabinet. This information is so helpful!

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Profile picture for mgd46 @mgd46

I had very good success tapering by measuring beads. Purchased jewelers scale and capsules. Weighed beads in original capsule. Set up schedule by reducing bead weight by 10% each month based on previous month. Doing the same now with Temazepam (powder in capsules). Good luck on your tapering program. You can do it!

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in reply to @mgd46 Thanks. I am going to talk to my pharmacist, as I am sure she will help me in this regard. I do not want to purchase a jewelers scale for obvious reasons. I have a very close relationship with my pharmacist, and have no doubt that she will be able to prepare the medication as described. This way I know that it is being done correctly and eliminates the hassle for me to have a chemistry lab in my kitchen. Good advice, though and thank you again

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