Anyone using Amitriptyline HCL for Neuropathy instead of Gaba or Lyric

My doc tried me on that and I had a serotonin reaction. Scary thing!!. I am very sensitive to some drugs, so I'd suggest trying to get a few days supply and see how it goes. I am just taking flexural for neuropathy, back pain and tingling, pins and needles down my leg. I just take this at night so I can sleep.

@madmouse43 I take 25mg of Amitriptyline along with the max dose of Gabapentin ( 3600mg a day). The combo does help with the burning pain in my feet. I take the Amitriptyline at night and it does make me a bit drowsy. I hope you don't have any side effects and you find some relief.

@madmouse43, you may also be interested in these 2 related discussions:
- Amitriptyline use for neuropathy: https://connect.mayoclinic.org/discussion/amitriptyline-use-for-neuropathy/
- Amitriptyline 25 mg: https://connect.mayoclinic.org/discussion/amitriptyline-25-mg/

I take Amitriptyline 25 mg. at night for the chemo neuropathy on my feet, and to sleep. I love it. No side effects, uninterrupted sleep and I can’t tell if it’s helping my neuropathy or not. I take 100 my of Gabepentan twice/day also. I really think only time will help . Good luck

Im on lyrica for nerve pains. When it wasn’t lasting every six hrs, nortryptilline was rxd hoping it would have a synergistic effect for nerve pains.
Yrs ago amytripptilline was ineffective on its own. A pharmacist specialist suggested nortryptilline in tangent. Just after a month it’s presently working!

I was on Gabapentin, then Lyrica. I switched to Tegretol and it works much better for my burning pain, with no drowsiness or brain fog (for me). I am on a pretty high dose now - 400 mg am, 600 mg pm.

I take Gabapentin and Amitripline both. The Gabapentin helps with the pain and the other helps you sleep. I have been taking them for 13 years.

@madmouse43 Hi. I take 30mg (3x 10mg) of Amitriptyline at night and it helps me sleep. I don’t think it really helps with the pain or anything but I suppose it helps enough that I can get some sleep. I started at a low dose (10mg) because I am very sensitive to medication. I worked up to 50mg but had bad blurry/double vision. It still affects my vision quite a bit but not as bad as it did at 50mg. I’ve tried many other medications and like this the best. I can’t take gabapentin because it sedates me. I tried Lyrica and had a VERY bad experience with it. I can elaborate if you want to hear more but overall, despite the blurry/double vision, I experience the least amount of side effects from Amitriptyline than the many other drugs I’ve tried. Good luck! Wishing you well.

I use Lyrica (75mg, twice a day) and 30mg of Amitriptyline at night. I think it all helps with my CIPN, but it’s definitely not a “cure”.

I appreciate the information. So far I have been lucky that my PN only very rarely effects my sleep. I take a 10mg Melatonin gummy which helps me get to sleep. I am at the very beginning of this med regiment. Frankly the side effects posted for all three of these (Gabapentin, Lyrica and Amitriptyline) along with sometime questionable effectiveness cause me concern .