Anyone have nausea with Trintellix?

My granddaughter has been on Trintellix for a year and has had nausea and vomiting to the point where she saw a specialist and had an endoscopy. Nothing was found. Her doctor said she could reduce her dosage and that would tell her if the Trintellix is the cause. In her experience people could tell the difference in side effects right away. Granddaughter spiraled down and needed to resume the previous dosage with no relief from vomiting. Has anyone had a similar experience? What else can she do to determine the cause?

Had to stop taking this med because of nauseous

I'm feeling the same way. It hasn't made any difference on my mood even on the higher dose. Wondering if this is a good choice for trauma symptoms.....?

I had the same experience with nausea on the lowest dose. I persevered and went up to 10 and after three weeks to 15. It wasn't worse but more persistent. Finally, kept me awake. I am coming off this medication. I also felt I had more labile moods which wasn't an issue prior to taking trintellix.

I've been trying to find any reported connection between Trintellix and the development of gastropariesis or other diseases related to the effect of the nervous system on the stomach/intestines. (Symptoms of gastropariesis include many things also described as side effects of Trintellix, but that doesn't prove a cause, so reporting is difficult.*) But I'd like to know if any doctors/researchers have looked into whether the unique way Trintellix works on the nervous system might be a *possible* explanation for a more serious effect than that of some other antidepressants (which affect the gut for only a few days).

I toughed it out about 2 years on Trintellix despite daily nausea, frequent vomiting, etc. for 4 hours every morning. ( For me, taking it at night = hard to sleep.)

Previously I'd had nausea and diarrhea the first 3 days of starting zoloft, which disappeared after 3 days. So I put up with Trintellix b/c it was working well, hoping the side effects would disappear. After about 2 years they disappeared for just a very short time, 1.5 months. Then returned, and over the next 2+ years I developed even more serious symptoms-- symptoms that are both listed as possible side effects of Trintellix (at drug dot com) AND listed as symptoms of gastropariesis (at mayoclinic.org/diseases-conditions/gastroparesis/symptoms-causes/syc-20355787) and other gut diseases. My GP had no information on Trintellix.

I decided to stop the Trintellix 9 months ago , but very concerning gut symptoms still remain, and I recently needed an endoscope and CT scan. Now I'm just hoping to find a psychiatrist knowledgeable enough to suggest a different antidepressant.

My belief is that it would be very important to let patients know about any reports of even possible connections between Trintellix's effects on the nerves in the stomach/intestine and a long-term alteration of how the gut works. Since it can be life-changing when the gut stops working well, it's not enough to only view problems as separate side effects in a list, that usually go away, which is what I did.

Mental health affects everything in one's life, so I understand that a psychiatric view ("How are you today/this week/this month?" and "Have your side effects been reported to be a probable connection to the med?") could assess patient concerns about a med. But that focus deals only with the short term. Dismissing side effects cannot be a one-size-fit-all decision, because long term damage to the gut has huge effect on mental health. ( In my experience, a psychiatrist in Portland was quick to dismiss all side effects as unconnected. But he later admitted being poorly informed and, I later learned, even had past state sanctions from 2 other states before moving here.)

I'm not at all arguing against long term use of antidepressants. I'm not alarmist. BUT again, long term effects on the gut can have huge effect on mental health. And perhaps some antidepressants are safe short term, but not long term.

Anyway, I'm hoping that reporters or med info systems like mayoclinic or johns hopkins or harvard, could look into the question of Trintellex's possible effects on nerves in the digestive system. For me it seemed to work well for "brain communication" but mess up the necessary communication in my digestive system. I hope that can be restored.

* I expect the company, and the current medical system used to fairly associate the probability of a side effect's connection to a drug, will not ID a definite link, because there are too many unknowns re gastro symptoms. However, a medical reporter could examine the question.

I was recently prescribed Trinellix at 10mg. I found that taking it WITH food alleviates the nausea. It doesn't work the same when taking it when the stomach is full (I tried this and I felt nausea). I've been taking it midphase during my breakfast (again W/ FOOD) and so far, so good.

I take 5 mg and it works and I take with food and nausea medication. Hope this helps.

I was taking 20mg Trintellix for about 6 months and I never got past the nausea. My doctor told me that it would eventually pass, but i was often 50% myself for 3-4 hours after my morning Trintellix dose because the nausea was so uncomfortable. If I ate breakfast within a few hours after the morning dose, I sometimes hurled it back up. If I didn't vomit, it would take >3 hours until the nausea subsided and I felt like I was willing myself not to Ralph during that period meaning concentration on work suffered. I demanded a med change and the nausea was gone immediately. At my next new med follow up visit, my doctor told me she was asking other trintellix patients about nausea and she was very surprised that up to half of those patients had post dose nausea tor other uncomfortable GI symptoms to some degree even after many months of treatment. Be a squeaky wheel. Don't accept medication side effects that affect your quality of life, even if the medication is helpful in improving your depression symptoms. There are many options and one if them will fit your needs.

@sarahl2616 - I have been having stomach issues since 2020 as well. I was on Trintellix for 4 years before that without issue but sometime around May of 2020 I started having the exact same issues as you and went to a gazillion doctors looking for answers and finally had major surgery only to have that not cure the issue and then Doctors started asking if I've ever been diagnosed with gastroperesis. I'm still searching for answers but like you, I think it was the Trintellix.