Anyone have nausea or other GI issues with Trintellix?

Hi Erika, I have been taking 10 mg of Celexa plus 1 mg of Clonazepam to help with anxiety since 2010. I could never take more than 10 mg because it exacerbated my restless leg syndrome which is very severe. I suffered from spinal stenosis also causing me great pain in my neck area and was given Gabapentin 900 mg per day. I had an ablation procedure finally which eliminated my pain but I continue to take the Gabapentin once I realized it worked for restless leg syndrome and my severe symptoms return if I stop it. This pandemic has caused my chronic depression to ramp up. I tried to go up to 20 mg of Celexa but my legs flared up. So I cut back to 15 mg which I can tolerate and has helped but I battle keeping the sadness at bay. That is why my friend with chronic depression recommended I try Trintellix also. I am very reluctant to tamper with my Celexa because I have suffered so much my whole life with restless legs. My doctor is willing to work with me on the antidepressant but will not increase my Gabapentin which I don’t want to do either. So that prompted my question regarding Trintellix and restless legs. Thanks so much for your inquiry.

I've been taking trintellex for about 22 days now and all of a sudden have terrible nausea. Has anyone else experienced this delayed reaction?

@sharielliker Welcome to Mayo Clinic Connect, a place to give and get support.

You are having nausea but the side effect started 22 after you started the medication. You are wondering if any member s have experienced this as well.

You will notice that I moved your question to a previous discussion. I did this so you could more easily connect with members like @sls87113 @heidi1346 @marjou @lacy2 @kelster69 that may be able to help, in a central location.

It sounds like nausea is a common side effect. May I ask if your provider offered to prescribe anti-nausea pills?

@sharielliker Yes, this is common side effect. It took me a couple of days but tried and retried med but still had upset stomach and nausea.

@erikas Regarding Trintellix... side effects. Yes, stomach upset, nausea are possible side effects which I have personally experienced a few days into taking this med

Yes and it’s brutal. Still after a full week. Stopping can’t take it anymore

@sunshinestacy I'm sorry to hear that. May I ask what your provider has advised? Will they prescribe another medication or is there something they can do to lessen the awful titration side effects?

I have an appointment tomorrow but I read that a therapeutic dose of prozac ccan help so I just took one. Cannot wait til tomorrow. Feeling a bit better. 10 mg. Will probably ween off everything sick of all the side effects and use prozac to ween off as it is the easiest to stop.

If you are sick on five I believe it will get worse on ten.

Have an appointment tomorrow but I have read and done before using therapeutic dose of 10 mg prozac to get off most antidepressants. I can’t wait until tomorrow so I finally just took one. I think I would take another in a few days then add a day in between each time something to that sort but talking to dr tomorrow will keep you posted