1. < Depression & Anxiety

Effexor and Mirtazapine: Any experience with this combo?

Posted by doorman @doorman, Aug 31, 2019

Been on 7 different meds for anxiety. None have worked. In fact, the last one ( Zoloft) caused me to have WORSE anxiety. It sent me to the ER, and a voluntary commitment to a psych ward. One of the worst 3days of my life. I’m now on Effexor and Mirtazapine ( California rocket fuel). Been on it for 3 weeks. Still feel like crap. I’ve been told it takes a minimum of 6 weeks to start working. I’m not looking forward to the next 3weeks. Anyone here have any experience with this drug combination?

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caf | @caf | Jun 24, 2020
In reply to @doorman "I know what severe anxiety is, believe me. So sorry for you. I tried Lexapro. It..." + (show)
@doorman

I know what severe anxiety is, believe me. So sorry for you. I tried Lexapro. It didn’t work for me. The Mirtazapine in the evening is a godsend. Be careful with relying on the clonazapan......I’m sure you will not let it get ahead of you. Best of luck to you my friend!

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Did the mirtazapine work right away? I’m on my first night , been on 150 Effexor for three weeks, no appetite and trouble sleeping thanks for your feedback!

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1 reply
doorman | @doorman | Jun 25, 2020
In reply to @caf "Did the mirtazapine work right away? I’m on my first night , been on 150 Effexor..." + (show)
@caf

Did the mirtazapine work right away? I’m on my first night , been on 150 Effexor for three weeks, no appetite and trouble sleeping thanks for your feedback!

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The Mirtazapine worked very quickly for me. It’s affinity for histamine receptors causes sedation. And it helped me tremendously getting to sleep. Effexor works on norepinephrine, which can cause a feeling of “jumpiness.” That’s why I only start ONE MED AT A TIME. Give the Mirtazapine more time. I did poorly on Effexor. Good luck.

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thewiltshires68 | @thewiltshires68 | Mar 30, 2023
In reply to @pankaj "@doorman: Mirtazapine is very effective in calming anxiety. But Effexor (Venlafaxine) does not suit everyone, so..." + (show)
@pankaj

@doorman: Mirtazapine is very effective in calming anxiety. But Effexor (Venlafaxine) does not suit everyone, so one has to be careful with it. It did not suit me and I suffered a terrible withdrawal reaction when I stopped it after taking it for just three weeks. At what dosage are you taking it? How is your body reacting to it? Please indicate the dosages of both meds. Also, are you taking any benzodiazepines or other anti-anxiety meds for immediate relief?

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I have been taking Effexor 37.5 for 3 weeks and it has made me extremely short of breath. Anyone else experience this? It’s like it has lessened the benefits of my trelegy inhaler. I did not take it last night because I want off this crap and I feel worse now than when I started it. Any advice? I know I can take Prozac but not sure if I can just switch. Seeing my Dr. tomorrow but I absolutely will not be continuing this medication if she ask me to. NO WAY!!

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1 reply
pankaj | @pankaj | Mar 30, 2023

@doorman: Your concern is well founded. Please tell your doctor about your suffering, and request her to switch your medication to another medicine such as Prozac. All good wishes.

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1 reply
thewiltshires68 | @thewiltshires68 | Mar 30, 2023
In reply to @thewiltshires68 "I have been taking Effexor 37.5 for 3 weeks and it has made me extremely short..." + (show)
@thewiltshires68

I have been taking Effexor 37.5 for 3 weeks and it has made me extremely short of breath. Anyone else experience this? It’s like it has lessened the benefits of my trelegy inhaler. I did not take it last night because I want off this crap and I feel worse now than when I started it. Any advice? I know I can take Prozac but not sure if I can just switch. Seeing my Dr. tomorrow but I absolutely will not be continuing this medication if she ask me to. NO WAY!!

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I didn’t know how to start my own thread so I posted mine above, I hope that’s ok

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thewiltshires68 | @thewiltshires68 | Mar 30, 2023
In reply to @pankaj "@doorman: Your concern is well founded. Please tell your doctor about your suffering, and request her..." + (show)
@pankaj

@doorman: Your concern is well founded. Please tell your doctor about your suffering, and request her to switch your medication to another medicine such as Prozac. All good wishes.

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My dr switched me from Prozac to this crap and I trusted her so agreed. I have Prozac here and so want to take one because as the evening is passing I am starting to feel blah from not taking that dang Effexor last night.

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tncowgirl | @tncowgirl | Dec 21, 2024

Yes I take 150 time release effexor with15mg of mirtazapine and I have had no problems with them since I started that was about 5 years ago. I have taken a lot of different pills for depression this does me good. I hope it will for you.

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louise60 | @louise60 | Dec 24, 2024

I was taking Effexor for years at maximum dose. Then they weaned me off. Clonazepam at 8mg/day for years was an absolute nightmare to come off. All drugs are hard to come off but Clonazepam has to be the worst. 5 years later I have recovered and weaned from Lyrica which I was given to combat the body dependence. I am still taking only 15mg Mirtazapine down from 45mg. Will wean from this during Jan. Frankly I prefer to cope without drugs as the effects of being put on and taken off drugs for 30 years has destroyed my life. I am now the healthiest I have ever been using regular exercise and good nutrition to manage my mental health. I am an expert on psychiatrists and prescription drugs and I’m so happy to almost have been discharged from their care.

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