1. < Blood Cancers & Disorders

Jak2 and Vitamin D3

Posted by lindaw123 @lindaw123, Dec 13, 2021

I read there is a study of affects of Vitamin D3 and the JaK2 mutation.
They have found correlation w D3 and bone morrow??? Anybody up on this?

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styleesteve | @styleesteve | Jan 24, 2023
In reply to @eileen11108 "Hi Steve, Welcome to this wonderful site. I have ET JAK2 and have found the site..." + (show)
@eileen11108

Hi Steve,
Welcome to this wonderful site. I have ET JAK2 and have found the site so helpful.

Since you are in the research stage I suggest you also look at healthunlocked.com. There has been a lot of discussion also on PV and Pegasys. It is a site based in the United Kingdom by MPN Voices but participants are from around the world.
Best wishes, Eileen

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Hi Eileen, many thanks for that, I really appreciate it.

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sandy1959 | @sandy1959 | Jan 25, 2023
In reply to @hopeful33250 "Hello @lindaw123 I appreciate this thoughtful question. I did some research online and found the results..." + (show)
@hopeful33250

Hello @lindaw123

I appreciate this thoughtful question. I did some research online and found the results of a research study on this topic at the National Insitute of Health website. Here is the link,
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053540/. The article is titled: Vitamin D Deficiency and Janus kinase 2 V617F Mutation Status in Essential Thrombocythemia and Polycythemia Vera."

If you read the study and especially the Conclusion it says:

"Conclusion
There was a remarkably higher prevalence of vitamin D deficiency in JAK2 mutation-positive ET and PV patients. These patients should be carefully evaluated for vitamin D deficiency. More studies are required to further investigate the association between JAK2 and vitamin D.

Keywords: vitamin D deficiency, chronic myeloproliferative neoplasia, polycythemia vera, essential thrombocythemia"

How are you feeling with your diagnosis?

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I am on Hydroxyuria for ET. I have the JAK 2 mutation as well. After reading this article I intend to start taking Vitamin D supplement. Any suggestions on the dosage?

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1 reply
Mentor
Teresa, Volunteer Mentor | @hopeful33250 | Jan 25, 2023
In reply to @sandy1959 "I am on Hydroxyuria for ET. I have the JAK 2 mutation as well. After reading..." + (show)
@sandy1959

I am on Hydroxyuria for ET. I have the JAK 2 mutation as well. After reading this article I intend to start taking Vitamin D supplement. Any suggestions on the dosage?

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Hi @sandy1959

On Mayo Connect, we are not medical professionals, just patients like yourself. For information on whether or not Vitamin D supplements are appropriate for you and for information on recommended dosages, please consult with your physician.

Checking your current Vitamin D level is done by a simple blood test. Has your Vitamin D level been tested recently?

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1 reply
sandy1959 | @sandy1959 | Jan 25, 2023
In reply to @hopeful33250 "Hi @sandy1959 On Mayo Connect, we are not medical professionals, just patients like yourself. For information..." + (show)
@hopeful33250

Hi @sandy1959

On Mayo Connect, we are not medical professionals, just patients like yourself. For information on whether or not Vitamin D supplements are appropriate for you and for information on recommended dosages, please consult with your physician.

Checking your current Vitamin D level is done by a simple blood test. Has your Vitamin D level been tested recently?

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Thank you for your response. My Vitamin D levels have not been checked. My MCH levels and platelet levels were flagged high. I am on 500mg of Hydroxyuria and a low dose aspirin. My B12 and iron levels have been high in the past. I will certainly ask the doctor about the Vitamin D. Best Regards

REPLY
1 reply
Mentor
Teresa, Volunteer Mentor | @hopeful33250 | Jan 25, 2023
In reply to @sandy1959 "Thank you for your response. My Vitamin D levels have not been checked. My MCH levels..." + (show)
@sandy1959

Thank you for your response. My Vitamin D levels have not been checked. My MCH levels and platelet levels were flagged high. I am on 500mg of Hydroxyuria and a low dose aspirin. My B12 and iron levels have been high in the past. I will certainly ask the doctor about the Vitamin D. Best Regards

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Hi @sandy1959,

That all sounds good. I would enjoy hearing from you again. Will you post after your Vitamin D levels have been checked?

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1 reply
sandy1959 | @sandy1959 | Jan 25, 2023
In reply to @hopeful33250 "Hi @sandy1959, That all sounds good. I would enjoy hearing from you again. Will you post..." + (show)
@hopeful33250

Hi @sandy1959,

That all sounds good. I would enjoy hearing from you again. Will you post after your Vitamin D levels have been checked?

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Yes.

REPLY
1995victoria | @1995victoria | Jan 25, 2023
In reply to @eileen11108 "Hi Steve, Welcome to this wonderful site. I have ET JAK2 and have found the site..." + (show)
@eileen11108

Hi Steve,
Welcome to this wonderful site. I have ET JAK2 and have found the site so helpful.

Since you are in the research stage I suggest you also look at healthunlocked.com. There has been a lot of discussion also on PV and Pegasys. It is a site based in the United Kingdom by MPN Voices but participants are from around the world.
Best wishes, Eileen

Jump to this post

I also have ET JAK2 taking HU. My primary tested me some years before diagnosis, and I had Vit D deficiency, so I take Vit D 3 almost every day (I forget sometimes). My Vit D is now in normal range, but didn't change ET

REPLY
carolann21 | @carolann21 | Jan 26, 2023
In reply to @jerrlin "I was diagnosed with PCV 3 months ago, but had itching symptoms since 2019. I tested..." + (show)
@jerrlin

I was diagnosed with PCV 3 months ago, but had itching symptoms since 2019. I tested positive for Jak 2 and a bone marrow biopsy confirmed it. I am on 2 baby aspirin a day and phlebotomy’s as needed. I’m wondering if anyone has found relief for the itching and minor fatigue. Unless chemo would slow this disease, I’ll stay with my current regiment. Any advice?

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Have you researched black seed oil?

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1 reply
jerrlin | @jerrlin | Jan 26, 2023
In reply to @carolann21 "Have you researched black seed oil?" + (show)
@carolann21

Have you researched black seed oil?

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No, I have not, I will research Black seed oil.Thanks

REPLY
tennis7777 | @tennis7777 | Feb 19 1:52pm
In reply to @jerrlin "I was diagnosed with PCV 3 months ago, but had itching symptoms since 2019. I tested..." + (show)
@jerrlin

I was diagnosed with PCV 3 months ago, but had itching symptoms since 2019. I tested positive for Jak 2 and a bone marrow biopsy confirmed it. I am on 2 baby aspirin a day and phlebotomy’s as needed. I’m wondering if anyone has found relief for the itching and minor fatigue. Unless chemo would slow this disease, I’ll stay with my current regiment. Any advice?

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For the itching I stopped taking showers in the winter. I wash my hair in the sink and wash my smelly bits with baby wipes. I can tolerate showers in the summer if they are quick.

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