Palmitoylethanolamide (PEA): Anyone had success?

Posted by wisfloj @wisfloj, Jan 26, 2020

Palmitoylethanolamide (PEA) user for at least 6 months. Seemed to work after several weeks, then not, then somewhat, now not at all and the burning pain is spreading to most of my body. Anybody find success? Is this how it works for you as well? Just hate to throw away money and continue unnecessary/ ineffective supplements. I use the Ergomax brand.
Thank you fellow sufferers! Appreciate this forum and people willing to share, advise and encourage!

Interested in more discussions like this? Go to the Neuropathy Support Group.

sharka | @sharka | Aug 19, 2022

Hello! Does anyone used PEA (Palmitoylethanolamide), for neuropathy?

John, Volunteer Mentor | @johnbishop | Aug 19, 2022

In reply to @sharka "Hello! Does anyone used PEA (Palmitoylethanolamide), for neuropathy?" + (show)

Hi @sharka, You will notice that we merged your post into an existing discussion on the same topic here - Palmitoylethanolamide (PEA): Anyone had success?: https://connect.mayoclinic.org/discussion/pea-success/

If you click the link, it will take you to the start of the discussion where you can read what others have shared on Palmitoylethanolamide (PEA). @wisfloj and @nukhan may have some thoughts for you on PEA. Here's an article that may be helpful...
--- Effect of PEA-OXA on neuropathic pain and functional recovery after sciatic nerve crush: https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-018-1303-5

jfn | @jfn | Aug 20, 2022

In reply to @lioness "@darlingtondoll I have fibromyalgia symptoms and neuropathy and cant do night shade vegetable at all No..." + (show)

Hi @lioness71

I use brown sugar to help counter act the acid when making tomato sauce. I have food allergies and make everything from scratch, so other cooking questions welcome.

johnmacc | @johnmacc | Nov 24, 2022

In reply to @margaretob "Just started on Gabapentin @ night for leg cramps. DOES NOT HELP.....will see a NEUROLOGIST on..." + (show)

Ask your doc to slowly boost your gaba script till it starts working. I'm at 3600 mg daily which is a max dosage. It cuts my pn in my feet by about half which at least tolerable. I also soak them in hot water each eve. for 15 minutes. If they still hurt I rub 4% lidocaine on them which rapidly numbs them into submission. Johnmacc

jdiakiw | @jdiakiw | Jan 14 4:06pm

Anyone tried PEA? THIS study. Says. Full link at end ‘
Conclusions
The present results demonstrate the neuroprotective properties of PEA in a preclinical model of neuropathic pain. Antihyperalgesic and neuroprotective properties are related to the anti-inflammatory effect of PEA and its ability to prevent macrophage infiltration in the nerve. PPAR- stimulation is the common pharmacodynamic code.

https://www.hindawi.com/journals/mi/2013/328797/#

John, Volunteer Mentor | @johnbishop | Jan 14 5:50pm

In reply to @jdiakiw "Anyone tried PEA? THIS study. Says. Full link at end ‘ Conclusions The present results demonstrate..." + (show)

Hello @jdiakiw, You will notice that we moved your post into an existing discussion on the same topic below. If you click the link it will take you to the beginning of the discussion so that you can read what others have shared.
--- Palmitoylethanolamide (PEA): Anyone had success?: https://connect.mayoclinic.org/discussion/pea-success/

mayonaise28 | @mayonaise28 | Jan 15 8:14pm

I tried Life Extension PEA for about a month. Expensive. Didn't seem to do anything. The dose was 1200mg/day, which may not have been sufficient.

artemis1886 | @artemis1886 | Jan 17 1:30pm

In reply to @catro "My PN symptoms come and go. Yesterday was a good day. Then last evening I ate..." + (show)

I have been told by a dietitian to avoid nightshade vegetables red meat and pork. I will be truthful it comes and goes. Sometimes I have problems with tomatoes and other times I don’t. I normally eat flounder or sea bass with cucumber and tomatoes. Hush puppies I use an air fryer to cook. No problem if I eat cucumber and tomatoes with red meat I stay up all night in pain. I avoid red meat and pork. The protein in red meat is hard on the liver along with the kidneys. Red meat really hurts me (all over) so does pork. Chicken, turkey breast and fish, some seafood (shrimp, scallops, and lobster no problems) nothing fried. Fried makes it worse. I cook the scallops in lemon juice. The shrimp steamed in the seafood department along with the lobster or sometimes I steam it myself.
Berries are supposed to help. I eat a lot of berries my downfall. Strawberries raspberries blueberries blackberries.
I love watermelon but I discovered sometimes I hurt more after eating a lot of watermelon. Truthfully, I don’t believe there is a clear answer to getting rid of the pain. I have been trying to eat low glycemic foods like the dietician said. I do not have diabetes. There’s more research in neuropathy with diabetes than those that are not diabetic I have noticed. Reading the American Journal of medicine or neurology.

gody6 | @gody6 | Feb 18 10:30am

I’m seeing results with ultramicronized PEA . After 2 weeks my sleep has improved dramatically. I think memory and sense of well being too .
The PEA has to be micronized or ultramicronized to be effective. Look for Levagen Plus on the label .Normast is also ultramicronized but I think only available from
a company called Naturitas ( imported).

bayhorse | @bayhorse | Feb 19 3:43pm

I am using Enzyme Science brand PEA+. It is ultra-micronized andcontains 300 mg PEA and also 500 mg curcumin in every 2-capsule dose. It is not a miracle-worker, but I think it has helped somewhat with my nerve pain. The downside: it ain't cheap. But now that I'm using PEA+, I no longer have to buy the stand-alone curcumin supplement that I was taking for inflammation. So the cost is worth it for me.