1. < Osteoporosis & Bone Health

Do Prolia injections affect the kidneys?

Posted by spiritbird2 @spiritbird2, Mar 30, 2016

I have been on Prolia injections for 2 years now. My kidneys were being effected by a lowering of GFR to 45. I am now on a years vacation from Prolia and GFR has increased to 50. My doctor said Prolia does not effect the kidneys. So now I am confused.

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hlh | @hlh | Jun 19, 2022
In reply to @jbcobb2380 "I had 9 hemorrhagic UTIs in a year on Prolia. Yes, it definitely affects kidneys and..." + (show)
@jbcobb2380

I had 9 hemorrhagic UTIs in a year on Prolia. Yes, it definitely affects kidneys and urinary tract. I had to convince my doctor this was due to Prolia. He discounted my experience. Not one hemorrhagic UTI since stopping Prolia. No fractures either and it’s been 3 years. I am on vacation from all meds right now. Only calcium, strontium, vitamin D,K, biotin and weight bearing exercise. Hope to maintain. So many meds through the years….

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My doctor told me stopping Prolia injection could cause immediate problem such as bone fracture… but you said you have stopped it for three years without any osteoporosis treatments and so far so good? Thanks for the info. Have you had bone density scan lately and how are they?
Helen

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2 replies
jbcobb2380 | @jbcobb2380 | Jun 19, 2022
In reply to @hlh "My doctor told me stopping Prolia injection could cause immediate problem such as bone fracture… but..." + (show)
@hlh

My doctor told me stopping Prolia injection could cause immediate problem such as bone fracture… but you said you have stopped it for three years without any osteoporosis treatments and so far so good? Thanks for the info. Have you had bone density scan lately and how are they?
Helen

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Initial decline but now one hip improved. Maintaining -2.8 and -2.6. Spine cannot be measured due to severe scoliosis.

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1 reply
hlh | @hlh | Jun 19, 2022
In reply to @jbcobb2380 "Initial decline but now one hip improved. Maintaining -2.8 and -2.6. Spine cannot be measured due..." + (show)
@jbcobb2380

Initial decline but now one hip improved. Maintaining -2.8 and -2.6. Spine cannot be measured due to severe scoliosis.

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Thank you for your prompt reply! Wish you the best!

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1 reply
jbcobb2380 | @jbcobb2380 | Jun 20, 2022
In reply to @hlh "Thank you for your prompt reply! Wish you the best!" + (show)
@hlh

Thank you for your prompt reply! Wish you the best!

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I hope you make the best decision for your body. If you can tolerate Prolia, it’s great. Some people just can’t. I was one of those.

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patmills | @patmills | Jun 21, 2022
In reply to @hlh "My doctor told me stopping Prolia injection could cause immediate problem such as bone fracture… but..." + (show)
@hlh

My doctor told me stopping Prolia injection could cause immediate problem such as bone fracture… but you said you have stopped it for three years without any osteoporosis treatments and so far so good? Thanks for the info. Have you had bone density scan lately and how are they?
Helen

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I got off Prolia shot in December 2021 and had 3 bone fractures after being off of it for 7 months . Doctor put me back on Prolia and after 4 months on it now she wants me to take the Evenity shots for a year . I’m unsure of taking the Evenity shots . Are there any comments from women who have actually taken the shot about the side effects they might have had

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1 reply
llewellyn41 | @llewellyn41 | Jun 27, 2022

Can Prolia injections cause kidney failure ?

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1 reply
chickie | @chickie | Jun 27, 2022
In reply to @kj58 "The side effect may not be listed until enough people complain of the issue. It is..." + (show)
@kj58

The side effect may not be listed until enough people complain of the issue. It is not to say that they have reported and gathered all of the side effects. Someone else mentioned this site. http://www.fda.gov/medwatch/report.htm or you can call 1-800-332-1088. You might report your increased GFR to them. Although, it would be hard to prove that it was related to a possible side effect of the medication or just an increase in water intake (which can increase GFR) also. I had my mother ask her Urologist if she should take Prolia. He was not too concerned but she is not severe CKD but a Stage 3. All drugs have SEs, just need to find one that U & your MD feel comfortable with. Best of Health to All!

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I don't understabd acronyms - please write it out. ?
GFR
CKD. ?

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1 reply
Mentor
Lori, Volunteer Mentor | @loribmt | Jun 27, 2022
In reply to @llewellyn41 "Can Prolia injections cause kidney failure ?" + (show)
@llewellyn41

Can Prolia injections cause kidney failure ?

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Hi @llewellyn41 There’s a discussion in Connect regarding Prolia Injections and whether the medication used for bone strengthening can cause kidney failure. Other members have asked the same question.
https://connect.mayoclinic.org/discussion/i-have-been-on-prolia-injections-for-2-years-now-my-kidneys/
From what I’m reading on the Prolia website, kidney damage isn’t listed in the adverse side effects. Though using Prolia is contraindicated for anyone who has kidney issue or is on dialysis. https://www.prolia.com/possible-side-effects
Are you using Prolia? Has your kidney function changed since receiving the injections?

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1 reply
2121 | @leslie2121 | Jun 28, 2022
In reply to @patmills "I got off Prolia shot in December 2021 and had 3 bone fractures after being off..." + (show)
@patmills

I got off Prolia shot in December 2021 and had 3 bone fractures after being off of it for 7 months . Doctor put me back on Prolia and after 4 months on it now she wants me to take the Evenity shots for a year . I’m unsure of taking the Evenity shots . Are there any comments from women who have actually taken the shot about the side effects they might have had

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Hello:
I’m 63 and have osteoporosis- not sure why? I had 2 thoracic compression fractures from a minor bump snow skiing. Very painful but have healed on their own, thankfully. That was 6 months ago.
I started Evenity in February and had my 5th injection last week.
I had some soreness, mild achiness afterwards but not enough to take anything. I walk at least 30 minutes a day and do core exercises & easy weight training my PT taught me, twice a week. Take calcium & Vit. D.
I don’t think I’m having much reaction to Evenity now.
I’ve had an occasional weird mild headache pressure sometimes- not sure if related? I just ignore it.
I have mild hypertension but controlled w small dose of amlodipine. Otherwise healthy.
That’s what I can share about my experience. I decided taking Evenity was worth the risk and hopefully it will get my bones strong so I can remain active and able to play with my 3 little grandkids.
I also decided to avoid alcohol and caffeine which may help?
Good luck!!😊

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1 reply
2121 | @leslie2121 | Jun 28, 2022
In reply to @chickie "I don't understabd acronyms - please write it out. ? GFR CKD. ?" + (show)
@chickie

I don't understabd acronyms - please write it out. ?
GFR
CKD. ?

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GFR=glomelular filtration rate or how well your kidneys work

CKD= chronic kidney disease

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