Parkinson's disease will be curable with cortisol

I OWE I OWE SO ITS OF TO WORK I GO. Seriously I take care of our home and 20 acres, raise a few sheep. Also, do some custom mowing and do some tractor repair. I keep wondering how I managed all this while driving a truck 150,000 miles per year. I never learned how to be a loafer. I will read your links, I have been looking at this disease from many angles and don't intend to go down easy. My cortisol May 4 was 2.0 at 08:00.

I haven’t been on Mayo Connect for awhile. I guess it’s because I have been doing really well until now. A very unwise and selfish thing to do, I might add. So now, of course, I return when I need help.
Anyway, I have just been taking 1 Sinemet tablet 3x a day for over 5 years now. I guess I am lucky because I know quite a few people who take a lot more, but it turns out that I’m not really so lucky after all. About 4 months ago I started noticing that the muscles in my thighs would spasm sometimes while I was sitting once maybe twice and then stop. It didn’t hurt, but was bothersome. As time has gone on it has become frequent when I am sitting with shorter periods of rest in between. Standing and walking are no problem. My doctor said it was dyskinesia and it is because my body is so sensitive to the Sinemet. He prescribed Amantadine, but it hasn’t worked. Has anyone else had this problem and/or been given Amantadine?
Appreciate your comments
Thanks

Amantadine made me very anxious, and I could not sleep. But it really helped with the PD symptoms. I wish I could take it. If it works for you without nervousness, take it.

I haven’t been on Mayo Connect for awhile. I guess it’s because I have been doing really well until now. A very unwise and selfish thing to do, I might add. So now, of course, I return when I need help.
Anyway, I have just been taking 1 Sinemet tablet 3x a day for over 5 years now. I guess I am lucky because I know quite a few people who take a lot more, but it turns out that I’m not really so lucky after all. About 4 months ago I started noticing that the muscles in my thighs would spasm sometimes while I was sitting once maybe twice and then stop. It didn’t hurt, but was bothersome. As time has gone on it has become frequent when I am sitting with shorter periods of rest in between. Standing and walking are no problem. My doctor said it was dyskinesia and it is because my body is so sensitive to the Sinemet. He prescribed Amantadine, but it hasn’t worked. Has anyone else had this problem and/or been given Amantadine?
Appreciate your comments
Thanks

I was on Amantidine at the beginning and that really helped my gait and stiffness. Unfortunately 2 weeks later I developed severe skin rashes all over so that had to be stopped. Was also on Azilect prior to Amantidine, that helped, but it also caused skin rashes, obviously that was stopped. I am now on Stelavo, Primaxine , also Neupro patch ; they don't work that well but I can function. They are considering doing DBS on me, but decision has not been made.
Does anyone have experience with DBS and would like to share it?

Hello @tuyetnga

It sounds as if you have tried a lot of medications and you and your medical team have been searching for answers. If you are interested in learning more about DBS, I would encourage you to read the narrative by one of our members. Here is the link to that discussion, https://connect.mayoclinic.org/discussion/deep-brain-stimulation-dbs/.

I would encourage you to seek out a Parkinson's Center of Excellence if you are thinking about DBS. Here is a listing of those centers from the Parkinson's Foundation website, https://www.parkinson.org/expert-care-research/centers-of-excellence/listing.

What is your most difficult symptom right now, @tuyetnga?

Most difficult for me is freezing of gait; equally difficult is bradykinesia!

I want to go back to the exercise part of the discussion. I have always been in good shape and pretty faithful to a regimen of walking and circuit weight training (weight machines 2-3 time/week). I was treated for an advanced case of prostate cancer 4 years ago now with no relapse so far.

Upon my diagnosis of PD my trainer told me to stop the weights and switch to resistance band training. I also learned from my research about Rock Steady Boxing, which is offered in specific gyms as a group class. My decision was I would be most faithful to the Resistance Band workouts I found on YouTube from a couple calling themselves HasFit fitness. The workouts are 30 minutes or longer and while they are strenuous, I seem to go by quickly and I feel good when they're done. If you just search YouTube for "HASFIT" you will find there are many different workouts under resistance bands to choose from.

I am curious though about others who have chosen other regimens of exercise and their results?