Hyperhomocysteinemia with MTHFR C677T mutations. Does anyone have this

@eErika is there a board for MTHFR gene mutations? I have MTHFR genetic mutation too. Connecting with others who have it and see knowledgeable is extremely beneficial.

single or double mutation? was diagnosed at John's Hopkins in Baltimore...still issues with enriched foods and vitamins. what are your questions? wife has it so has dealt with it for about 10 years.

Johns Hopkins doctor is Jack Ratchford. This was there in 2014 and don't know now. Not many doctors have any experience with this. Wife has double gene mutation of this. Not aware of any boards that deal with this. Sometimes the doctor or family member or nurse have the condition so then know what it is all about. A woman that works at a holistic pharmacy in Salisbury, MD has it as do her kids. CBD is not a problem with this. She avoids all enriched foods/synthetic foods and it usually says on the label whether enriched...

@erikas I found a pharmacist at a compounding pharmacy who was my first source of information and was a gem on knowledge. Since then, I've done a lot of research on my own via NIC, John Hopkins, and other well-known institutions, plus some other alternative options. Thanks for your response.

Hello @gldnrtrvrlvr

As it has been a while since you last posted I was wondering how you are doing. Will you post an update at your convenience?

Has anyone with the double mthfr variant received the COVID 19 vaccine?

My wife has experienced neuropathic pain in her legs and feet for years. Our primary care md at UAB’s Kirklin Clinic in Birmingham tested her vitamin B6 level and it’s extremely high at 174. She takes no supplements and as a pharmacist I started researching this and found that the C677T & A12980 mutations of the MTHFR gene could be the source of this elevated B6 as these mutations of these genes prevent the conversion of the synthetic b6 to p-5-p form of b6 that is used by our cells. In fact I find literature indicating that she could literally be low in the needed b6form used by her cells and could need supplements of p-5-p form of B6. In summary these mutations and B6 issues could be source of her peripheral neurophy pain in her lowe legs and feet. We cannot find Any md’s at UAB that know how to treat this condition and I’m reaching out to see if anyone else has dealt with this issue and if help is available at Mayo ofr John’s Hopkins to help us deal with this problem with clinical treatment.

Welcome, @monk1015. I encourage you to join the well informed members of the Neuropathy group here: https://connect.mayoclinic.org/group/neuropathy/

You'll get support, answers and guidance there.

@bet- Good morning and welcome to Mayo Clinic Connect. Have you spoken with your doctor about this? Have you had other vaccines?

The doctor is attempting to find more information and is reluctant to recommend the vaccine without more information. It appears there is limited information. The teaching university where records were sent has yet to respond after several phone calls. It appears there is limited and confusing research on this gene.
Other types of vaccinations have not caused major problems. Sensitivity to metals, medications, and foods have been issues.