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COPD and Emphysema: Confused by pulmonary function test and more

Posted by redsox @redsox, May 29, 2018

Confused by PFT. So much to absorb ! What are the treatments for Mild, Moderate and Severe ?

Interested in more discussions like this? Go to the COPD: Chronic obstructive pulmonary disease Support Group.

joangma | @joangma | Mar 2, 2019

there is good news there is STEM CELL and now ZEPHER VALVES talk to your doctors about these new break thru devices. good luck god bless you all. I have copd myself.

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Merry, Alumni Mentor | @merpreb | Mar 3, 2019
In reply to @clipper "@merpreb I hope my posts weren't too abrupt, I was rushing to get out the door...." + (show)
@clipper

@merpreb

I hope my posts weren't too abrupt, I was rushing to get out the door. I also didn't mean to imply it won't ever work, just that the companies selling stem cell therapy today have not undergone robust clinical studies showing it to be effective. All the class action lawsuits against the company selling it in the US would suggest otherwise.If you look at where the real science is today, it is very hard to imagine that anyone has a full blown successful stem cell therapy for lung disease.

I also need to correct something, there are clinical studies underway. There are 39 clinical studies, 14 are active. There are 12 studies that have completed, only two have published results. When results are published, it is usually because they don't have any. One of the two is the Lung Institute, the company that the FDA is trying shut down. The other one was a study done in Brazil and was legit but it was an open, non-randomized study with only 4 patients. It doesn't much look like much came from that.

However there is a lot of valid research going on so it remains hopeful. Here are some useful links I tried to keep it current, nothing older than 2017.

Feb 2018 Researchers have identified a lung stem cell that repairs the organ's gas exchange compartment, according to a new study from the Perelman School of Medicine at the University of Pennsylvania.
https://www.sciencedaily.com/releases/2018/02/180228131106.htmhttps://copdnewstoday.com/2018/03/06/copd-newly-identified-stem-cells-can-restore-lung-alveoli-mice/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146161/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864644/
https://med.stanford.edu/news/all-news/2017/11/researchers-find-lung-stem-cell-heal-lung-injury-in-mice.html
https://www.pulmonologyadvisor.com/home/topics/copd/adipose-tissue-transfer-lung-scaffolds-the-future-of-stem-cells-in-copd/2/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829274/

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@clipper- good morning. I didn't find that you were abrupt at all. Thank you for your hard work in your research. What a wealth of information and hope you have given all of us. Thank you. It's exciting to see medical advances happen in front of your eyes isn't it! To be able to freely breathe again, or near it is the future!

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1 reply
clipper | @clipper | Mar 3, 2019
In reply to @merpreb "@clipper- good morning. I didn't find that you were abrupt at all. Thank you for your..." + (show)
@merpreb

@clipper- good morning. I didn't find that you were abrupt at all. Thank you for your hard work in your research. What a wealth of information and hope you have given all of us. Thank you. It's exciting to see medical advances happen in front of your eyes isn't it! To be able to freely breathe again, or near it is the future!

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@merpreb
Morning. There is lots of really great research going on. We should all have hope, real science is amazing and the field of regenerative medicine will get us there.

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Merry, Alumni Mentor | @merpreb | Mar 3, 2019

Hip Hip Hooray @clipper! You are right on target!

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jgpolachek | @jgpolachek | Apr 2, 2019
In reply to @marczappa "Just joined to try and see if COPD/ Asthma, Emphysema can be helped by Stem Cell..." + (show)
@marczappa

Just joined to try and see if COPD/ Asthma, Emphysema can be helped by Stem Cell treatments . While medication has helped somewhat I am uncomfortable and short of breath most of the time.

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Marc; I've read Dr. Morrisey at Penn University found that AEP stem cells will regrow alveoli in mice. I also read where Mayo can produce millions of stem cells quickly. I would like them to get together and see if they could help each other find a cure.

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2 replies
bb729 | @bb729 | Apr 2, 2019
In reply to @jgpolachek "Marc; I've read Dr. Morrisey at Penn University found that AEP stem cells will regrow alveoli..." + (show)
@jgpolachek

Marc; I've read Dr. Morrisey at Penn University found that AEP stem cells will regrow alveoli in mice. I also read where Mayo can produce millions of stem cells quickly. I would like them to get together and see if they could help each other find a cure.

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A few years back I read some Japanese scientist discovered the same thing in mice and that more studies needed to be done. From what I've seen stem therapy doesn't seem to be toxic. It may not work but shouldn't kill you. Maybe I'm wrong but if not why can't the step up the pace?? I'm ready to be a human mouse 🙂

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jgpolachek | @jgpolachek | Apr 2, 2019

bb729; they all seem to give hope then pull rug out. The best lung Dr. I ever seen once told me I don't want you to give up hope, but remember there is no money in cures. He also said big Pharma control trials and a lot of doctors.

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Merry, Alumni Mentor | @merpreb | Apr 3, 2019

@jgpolachek- Welcome to Mayo Connect. I am a volunteer mentor with Mayo Connect. I'm a lung cancer survivor with COPD and Emphysema. One of my doctors told me about certain doctors and pharmacies playing with trials. It's disheartening at best. And I agree, how does that give hope to anyone?
May I ask what brings you to Connect and how can we help?

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3 replies
jgpolachek | @jgpolachek | Apr 3, 2019
In reply to @merpreb "@jgpolachek- Welcome to Mayo Connect. I am a volunteer mentor with Mayo Connect. I'm a lung..." + (show)
@merpreb

@jgpolachek- Welcome to Mayo Connect. I am a volunteer mentor with Mayo Connect. I'm a lung cancer survivor with COPD and Emphysema. One of my doctors told me about certain doctors and pharmacies playing with trials. It's disheartening at best. And I agree, how does that give hope to anyone?
May I ask what brings you to Connect and how can we help?

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About 12 years ago a friend was in trial at Cleveland Clinic for atherosclerosis a shot for six weeks of ApoA-1 Milano. Great results, Pfizer came in, pulled trial, paid 1.25 billion for all rights. This made possible all the money drug companies made on statin drugs. I was having flares every six months until I found good pulmonary, he put me on Zithromax three times a week m-w-f and started me on lung flute twice a day. My flares are now about every 2-3 years.

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1 reply
joelars | @joelars | Apr 3, 2019

I learned that Mayo is running stem cell trials for COPD. I understand the last trial was a disappointment with only 5-10% reporting substantial improvements. Still, 5-10% gives me hope. I'm trying to be included in the next trial, maybe by then they will have figured how to improve the outcomes.

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