1. < Depression & Anxiety
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Anyone have nausea or other GI issues with Trintellix?

Posted by nansmith @nansmith, Nov 1, 2017

Anyone have nausea with Trintellix 5mg? How long did it last? Been taking for almost 6 weeks and still have some nausea...will it get worse if I titrate to 10mg? Thanks.

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heidi1346 | @heidi1346 | Jan 17, 2021
In reply to @colleenyoung "Hi @heidi1346 and welcome to Mayo Clinic Connect. It sounds like Trintellix (vortioxetine) is causing several..." + (show)
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Hi @heidi1346 and welcome to Mayo Clinic Connect. It sounds like Trintellix (vortioxetine) is causing several digestive related issues for you, including nausea, upset stomach and severe diarrhea. Nausea is the most common side effect of this drug. I'd like to bring @rossjt @marjou @trip17 @elwooodsdad @petangelkat1 @jeanmnyc @marazion @alamogal635 and @kelster69 into this discussion so they can share their experiences with you.

While we wait for others to join in the discussion, you may also wish to see this discussion thread:
- Switching to Trintellix or Low Dose Naltrexone (LDN) https://connect.mayoclinic.org/discussion/trintillix/

Heidi, have you discussed the side effects you're experiencing with your doctor? How long have you been taking Trintellix? What dosage?

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I took two duculox the night before so maybe that is why the diarrhea is so bad. 5 mg

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heidi1346 | @heidi1346 | Jan 18, 2021
In reply to @colleenyoung "Hi @heidi1346 and welcome to Mayo Clinic Connect. It sounds like Trintellix (vortioxetine) is causing several..." + (show)
Profile picture for Colleen Young, Connect Director @colleenyoung

Hi @heidi1346 and welcome to Mayo Clinic Connect. It sounds like Trintellix (vortioxetine) is causing several digestive related issues for you, including nausea, upset stomach and severe diarrhea. Nausea is the most common side effect of this drug. I'd like to bring @rossjt @marjou @trip17 @elwooodsdad @petangelkat1 @jeanmnyc @marazion @alamogal635 and @kelster69 into this discussion so they can share their experiences with you.

While we wait for others to join in the discussion, you may also wish to see this discussion thread:
- Switching to Trintellix or Low Dose Naltrexone (LDN) https://connect.mayoclinic.org/discussion/trintillix/

Heidi, have you discussed the side effects you're experiencing with your doctor? How long have you been taking Trintellix? What dosage?

Jump to this post

I will be discussing with doctor tomorrow. 5mg for 4 days and like I said I took duculox the night before. Hope do i know when a discussion is in progress

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heidi1346 | @heidi1346 | Jan 18, 2021

Yes I got severe dishreah after the duculox. Maybe the diarrhea would not have been so bad if I didn't take the duculox

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heidi1346 | @heidi1346 | Jan 18, 2021

Has anyone gained weight on Trintellix

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heidi1346 | @heidi1346 | Jan 18, 2021
In reply to @colleenyoung "Hi @heidi1346 and welcome to Mayo Clinic Connect. It sounds like Trintellix (vortioxetine) is causing several..." + (show)
Profile picture for Colleen Young, Connect Director @colleenyoung

Hi @heidi1346 and welcome to Mayo Clinic Connect. It sounds like Trintellix (vortioxetine) is causing several digestive related issues for you, including nausea, upset stomach and severe diarrhea. Nausea is the most common side effect of this drug. I'd like to bring @rossjt @marjou @trip17 @elwooodsdad @petangelkat1 @jeanmnyc @marazion @alamogal635 and @kelster69 into this discussion so they can share their experiences with you.

While we wait for others to join in the discussion, you may also wish to see this discussion thread:
- Switching to Trintellix or Low Dose Naltrexone (LDN) https://connect.mayoclinic.org/discussion/trintillix/

Heidi, have you discussed the side effects you're experiencing with your doctor? How long have you been taking Trintellix? What dosage?

Jump to this post

I talk to my doctor tomorrow. I have been on 5 mg for four days. Maybe if I did not take the Ducolox, the diahreah would not have been so bad. Is weight gain a side effect. Hearing different things

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heidi1346 | @heidi1346 | Jan 18, 2021
In reply to @kelster69 "@heidi1346 , I was on Trintillex for about 6 weeks last summer. I did have nausea..." + (show)
Profile picture for kelster69 @kelster69

@heidi1346 , I was on Trintillex for about 6 weeks last summer. I did have nausea when I started taking it, and my doctor prescribed an anti-nausea I could take with it. That said, I started to tolerate the drug better after a couple of weeks. No diarrhea, but if the Trintillex works for your depression, maybe you could talk to your doctor about taking something to stop your diarrhea. I've learned that if you find something that helps you, it's worth putting up with the side effects (to a reasonable extent). Depression is hell and anything that you can arm yourself with to fight it is worth trying. All the best to you.

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Thank you

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marjou | @marjou | Jan 18, 2021
In reply to @heidi1346 "I am extremely nauscious from trintellix and have an upset stomach. I believe the Nausia goes..." + (show)
Profile picture for heidi1346 @heidi1346

I am extremely nauscious from trintellix and have an upset stomach. I believe the Nausia goes away but does the upset stomach go away

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I have the nausea and upset stomach at 2.5 mg.

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heidi1346 | @heidi1346 | Jan 25, 2021

I had to stop the Trintellix. The constipation was worse than the nausea. Anyone have severe constipation

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sls87113 | @sls87113 | Jan 31, 2021

I have a friend who has had amazing results with Trintellix for her depression. I have been on Celexa for many years. I can only take 10 mg because I have restless leg syndrome which I control by taking Gabapentin at night. Does anyone know how Trintellix affects restless leg syndrome.

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Erika | @erikas | Feb 4, 2021
In reply to @sls87113 "I have a friend who has had amazing results with Trintellix for her depression. I have..." + (show)
Profile picture for sls87113 @sls87113

I have a friend who has had amazing results with Trintellix for her depression. I have been on Celexa for many years. I can only take 10 mg because I have restless leg syndrome which I control by taking Gabapentin at night. Does anyone know how Trintellix affects restless leg syndrome.

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@sls87113 Welcome to Mayo Clinic Connect, a place to give support. You have support and information to share with peers.

You have a friend that has had amazing results from Trintellix for her depression.

You have taken Cenexa for some time. Is this to treat depression? You also take Gabapentin for restless leg syndrome. You are wondering if Trintellix affects restless leg syndrome.

May I ask how Celexa has been working for you?

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