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Estradiol cream and breast soreness

Posted by sandrajane @sandrajane, May 31, 2025

Anyone else? Breast soreness?
I used the pellets years ago with seemingly no problems. I did have an elevated d dimer when tested for fainting but we don't know what caused it. I started the cream about 2 months ago. 2 weeks ago I developed soreness in one breast and armpit. The PA doesn't think the cream could cause this but I am not so sure. I am stopping use to see if it goes away. I suspect this internal use hormone has more side effects than they want us to believe. I'm sorry to hear this because I really wanted to ease my at atrophy, uti like cramps and dementia down the road. I may ask for the pellets again.

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paisley52 | @paisley52 | Jun 22, 2025
In reply to @lamr "I’m mew to this whole vaginal extreme pain. I’ve been to 4 gyns and they told..." + (show)
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I’m mew to this whole vaginal extreme pain. I’ve been to 4 gyns and they told me estrogen cream was the answer. I tried it and it burned a lot. I also broke out in a rash they said was unrelated.
I have tried many lubricants and now I use Aquafor. It still doesn’t help with the pain in the clitoris area. I’ve also been doing a pelvic floor yoga program. It doesn’t help. Isn’t there a topical pain reliever I can use to help?
I take Tylenol and use an ice pack, also.

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I use amitriptyline compound, which you can mix with any cream. This seems to take my burning down.

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sandrajane | @sandrajane | Jun 22, 2025

I wish people wouldn’t hijack a post now I am getting alerts to answers to other people‘s questions that have nothing to do with what I asked

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tinedf | @tinedf | 5 hours ago
In reply to @sandrajane "First, my doctor told me that the cream could not cause breast tenderness so I told..." + (show)
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First, my doctor told me that the cream could not cause breast tenderness so I told her maybe I should switch back to the pellets again. And she messages me and tells me that the pellets can also cause breast pain. But you just said that the cream cannot cause breast pain?! How frustrating is this?

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@sandrajane this is a super late reply, did you get anything resolved? I got sore breathy and armpit pain when using estrogen cream too. Still use it, still pain. I did do mammograms and have everything checked and everything is fine. So it obviously is the cream that is the cause. I did try HRT for three weeks, but then the armpit pain become so unbearable that I stopped it.
The cream has not helped much either, using it for 3 years now….

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tinedf | @tinedf | 5 hours ago
In reply to @tinedf "@sandrajane this is a super late reply, did you get anything resolved? I got sore breathy..." + (show)
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@sandrajane this is a super late reply, did you get anything resolved? I got sore breathy and armpit pain when using estrogen cream too. Still use it, still pain. I did do mammograms and have everything checked and everything is fine. So it obviously is the cream that is the cause. I did try HRT for three weeks, but then the armpit pain become so unbearable that I stopped it.
The cream has not helped much either, using it for 3 years now….

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@tinedf meant sore breasts…

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sandrajane | @sandrajane | 1 hour ago
In reply to @tinedf "@sandrajane this is a super late reply, did you get anything resolved? I got sore breathy..." + (show)
Profile picture for tinedf @tinedf

@sandrajane this is a super late reply, did you get anything resolved? I got sore breathy and armpit pain when using estrogen cream too. Still use it, still pain. I did do mammograms and have everything checked and everything is fine. So it obviously is the cream that is the cause. I did try HRT for three weeks, but then the armpit pain become so unbearable that I stopped it.
The cream has not helped much either, using it for 3 years now….

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@tinedf I had mammo and ultra sound and saw the breast surgeon. All was clear. She showed me the films and explained nothing is showing. So all was kind of vague. I could just have sensitivity or it could be referred pain. As for the referred pain, I am getting nowhere either my doctors. I had ultrasounds on that side. Nothing. I worry about Costochondritis or heart, spleen, pancreas. Pretty stressful having this left sided issue for years and getting no answers.
Ask to get an ultra sound with mammo and speak to breast surgeon. I think we both are sensitive to the hormone and it’s not as rare as they lead you to believe. So many sites will tell you the cream or insert can not get into your system but we know that is total BS.

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