Anyone with COPD taking Nucala (mepolizumab)? How did it help?

The main way the biologics helped me is NOT having exacerbations one or more times/year. It’s not a miracle Rx that makes things FEEL a whole lot different or better.

Even when we had power outage for 89 hours & I had to sleep with pulse flow POC instead of my stationary continuous flow concentrator, no exacerbation. I’m very glad that problems like having to sleep with pulse flow POC don’t cause exacerbations. (In the past, I have gotten exacerbations when sleeping with POC.)

@bigbird1956 where is the file attached at

@john2563 wow sorry you not getting any relief from the Nacala, I’m suprised your not feeling anything being you took 5 injections, I just took my 8th, after I took the first it took couple weeks before I felt anything and moving forward it was slow but definitely felt a improvement, I was talking to another on it and she said I was where i should be on the nucala and it keeps getting better which it has, before I needed my portable oxygen to go food shopping or anything out side my home, I don’t need that no more, have you told your doctor about not feeling anything, I could be wrong but that doesn’t sound right, if your not happy have the doctor change it, it’s our body we know what helps us and what doesn’t so you do what you gotta do, I was only on breztri and Ohtuvayre and it wasn’t enough I had to tell him I want to try another and he started me on the nucala, so speak to your doctor it’s your choice, hope you find something that helps you ❤️

Thank you, maybe he needs to raise the dose for me. Do you have severe COPD like I do???

@snoots It showed attached but I don't know how to go back there, but here's the text that was in it......
JUNE 11 - 1ST PULMONARY VISIT (Used my rescue inhaler 7 times between June 1 and June 11)

JUNE 18 - 1ST NUCALA SHOT
June 29 - Last time I had to use my rescue inhaler
July 10 - Stopped using oxygen at night
July 14 - Did Sleep Study from Aprea
July 15 - Ultrasound on Neck
Results since shot:
- Only used the Rescue Inhaler 3 times since
- Oxygen was at 4 Litlre
- Started taking oxygen off briefly when watching tv/seated
- Dropped oxygen from 4 Litres to 3 when walking; 2 when seated
- Dropped oxygen from 2 to 1 when seated
- Swelling of ankes and lymph nodes in neck
- Began being able to sit and eat dinner without oxygen

JULY 16 - 2ND NUCALA SHOT
July 25 - 1st day of washing my face, makeup, brushing teeth without having to stop for oxygen
July 27 - 1st day of Therapy 1 Litre (Tredmill-7 minutes; Arms-8 minutes; Row-8 minutes)
JUly 29 - Melissa had me start using oxygen at night again due to Sleep Study results (1.5 Litre)
August 3 - 2nd week of Therapy 1 Litre (Tredmill-15 minutes; Arms-15 minutes; Row-15 minutes)
August 10 - Started being able to walk around the house a little bit without oxygen
Results since shot:
- Able to do small chores like putting dishes in dishwasher, prep for dinner a few minutes at a time
- Able to turn oxygen down to 1 litre in truck and eventually take it off
- No oxygen at dinner, watching tv, short walks around the house
- Length of time for being in kitchen improved from minutes to an hour
- Able to wash face, makeup, brush teeth without having to stop for oxygen
- Able to dry hair without having to stop for oxygen
- Able to strip the bed, load laundry, unload dryer without oxygen.

AUGUST 18 - 3RD NUCALA SHOT
August 25 - Able to work in the kitchen prepping and cooking without oxygen for over an hour
August 25 - Could bend over to get things out of the freezer, unload the diswasher, etc.
August 25 - At Therapy two out of three machines with NO oxygen (Tredmill-still at 1 Litre)
August 30 - Tried washing my hair without oxygen; not successful dropped from 95 to 71
Results since shot:
- Length of time in the kitchen has increased dramatically without having to stop for oxygen
- More and more walking without oxygen in our house

SEPT 17 - 4TH NUCALA SHOT (Scheduled)

My doctor is putting in an auth request with my insurance. I have a Medicare Part C Advantage plan. So is Nucala billed as a doctor's visit? My son has been on Zolar for years, and my neighbor has been on Nucala for years; they both do great with it. I can't wait I am fine as long as I sit but the minute I get up and move, my pulse ox drops to 85/88.

@john2563 well John I was approved for a oxygen concentrator in my bedroom and a portable and I would be out of breath just walking to my kitchen so I would say I am, I don’t need or use the concentrator so they picked that up but I kept the portable just incase we go away and I need it, but everyone’s body handles things differently, i started watching what I was eating and exercising everyday day just trying to keep living, I can’t exercise like most people so I bought the elliptical machine it’s just peddles on the floor like a bike and i peddle away, I can’t do a marathon but greatful that I can breathe better then what I was. Definitely talk to your doctor he’s supposed to help you

We have the auto inject version and my spouse injects me every 4 weeks with Nucala in my belly area. it’s much more convenient to take it on our preferred time than having to go to an md office for injections and my spouse is good at it. I’m not as good as I give myself bruises or have serum that drips out since I don’t get good angle.

My doctor is going to give me the first shot then I am going to give it to myself at home. Does anyone do it this way? How much does it cost?

@kat1359
Hello I'm still deciding also as I have rheumatoid arthritis and I already deal with swollen joints which is a side effect of dupixent and I don't need anything to make my R A worse