I’m starting Duloxetine for spinal stenosis pain, anyone have success?

Posted by Mariette R. @marietter, Aug 7 10:26am

My primary care has started me on Duloxetine for my chronic spinal stenosis pain. I felt that the Tramadol was not helping me enough. My pain clinic also started me back on Gabapentin. I do not want surgeries at my age 71, I just want to get to a pain level I can tolerate. I do have a NEVRO SCS which helps with CRPS and small fiber neuropathy in my left leg , but this doesn’t help with musculoskeletal pain and my stenosis pain. Opinions on Duloxetine?

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Profile picture for @lchop55 @karentheo

@lchop
I was on duloxitine (60mg) for many years, along with trazadone and mirtazipine. Did nothing for the pain. Per my doctor, pain will trump any medication like this. The trazadone does help to sleep, as does mirtazipine, which acts as an appetite stimulant. I've lost about 20 lbs since the pain makes me really nauseous. Unfortunately, my chronic lumbar pain makes it impossible to get a good solid night sleep. I've do take 15mg of tramadol which takes the edge off somewhat, but it's considered a lower type of narcotic. Gabapentin 300mg 3x, made me quite loopy during the day so that was stopped. Good luck to you, as I understand the total frustration.

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@karentheo Thanks, I have been on all those still weaning off Gabapentin down to 300mg still on 100mg Trazodone great for sleep but sedated all morning. Feel sometimes we are getting fobbed off and its almost impossible to see a GP. Worrying about going to bed has made me anxious and depressed knowing the sort of night I am going to have. How can I get Tramodol ? Told by GP I cant have an opiod whilst on Trazodone and Gaba. But I need a good pain killer. These others do not really kill the pain at night.

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Please be careful missing doses because it’ll make you feel like you’re on a 3 day drunk. Your head will spin and hurt and your equilibrium will be all off until you get it back in your system. It is also used for depression. I’ve been on it 7 years and have been slowly coming off it due to the side effects.

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Profile picture for kmoore1277 @kmoore1277

Please be careful missing doses because it’ll make you feel like you’re on a 3 day drunk. Your head will spin and hurt and your equilibrium will be all off until you get it back in your system. It is also used for depression. I’ve been on it 7 years and have been slowly coming off it due to the side effects.

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@kmoore1277 Thank you for your post. I’m from a medical background and am fully aware.
Thanks again.

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Profile picture for kmoore1277 @kmoore1277

Please be careful missing doses because it’ll make you feel like you’re on a 3 day drunk. Your head will spin and hurt and your equilibrium will be all off until you get it back in your system. It is also used for depression. I’ve been on it 7 years and have been slowly coming off it due to the side effects.

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@kmoore1277 I'm just starting duloxetine and wonder what are the side effects you've experienced with it and when did the side effects start, if you remember, and don't mind letting me know. Thanks!

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Profile picture for painsurvivor @painsurvivor

@kmoore1277 I'm just starting duloxetine and wonder what are the side effects you've experienced with it and when did the side effects start, if you remember, and don't mind letting me know. Thanks!

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@painsurvivor i started it a month ago for my lumbar spinal stenosis at starting dose for three weeks to see if I experienced any side effects. I did not. Then I went on to the maintenance dose and have been for almost two weeks now at this dose .
Occasional “eyebrow headache” as I call it. Which is a normal side effect when first starting this dose and should go away once your system has adjusted to it according to the pharmacy literature I was given with my script . Already I notice a marked improvement with my back discomfort . I do try to watch my body mechanics and not bend down to tie shoes or pick up things from the floor. Avoid twisting at the waist too, helps me. I bought grabbers to pick up things from the floor.
Hope you feel better and have less pain too.

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I would stay away from it. It helps with depression but not so much with pain.

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Profile picture for mslee56 @mslee56

I would stay away from it. It helps with depression but not so much with pain.

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@mslee56 I can now safely speak for myself after having been on it for about three weeks. It has definitely made a big difference in the pain I was experiencing in my back.

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I just started it yesterday for severe neuropathy pain. I praying for relief

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Profile picture for medicalunicorn @medicalunicorn

So i don't have the same condition, but I take duoloxetine for my fibromyalgia pain and its honestly been a life changer. Do I still have pain, yes, but my quality of life has benefited the most from cymbalta and Im at the max dose (120 mg)

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@medicalunicorn I didn't have any luck with Cymbalta for either pain or mood but everyone is different.
I wish it had worked.

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I have terrible neuropathy in both legs. I was taking 3 300 mg of gabapentin and it was killing me mentally and it bought me a little pain relief but not enough to justify taking it. My doctor suggested cymbalta "duloxetine" as a better alternative. We started with 20 mg to see if I could tolerate it. I was very nauseated for 4 days but I also weaned down to 1 gabapentin at the same time. After two weeks I was prescribed 2 20mg per day. I am still using 1 gabapentin. This has made a significant difference in leg pain that last longer and far less brain fog. I am going to try 60 mg a day in hopes of letting go of gabapentin completely. My doctor said over 60 mg is where you start to feel pain relief. I do yoga stretches everyday and that helps. I also added Gundry olive oil a week ago in the morning and my gut health plus skin and other benefits has been life changing. I did start R ALA supplement two mornings ago for nerve health. I must finally be doing something right because the pins and needles are improving and I am not giving up.

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