Lupron or Not at 76?

@pesquallie

I was about 85 when I took only 2 shots of Lupron and stopped.

Four years later, I STILL have not recovered my normal walking mobility.

My nurse practitioner said that testosterone replacement might cause more cancer.

@jimbo12

Current technology says that testosterone does not fuel prostate cancer after initial radiation treatment. The study at Baylor actually believe that low testosterone may accelerate and even cause prostate cancer. This is why my urologist prescribed TRT for me.

@jimbo12
I looked at a summary of the Baylor study and this may be the case. The results published were for patients with grade 1 PC/on active surveillance so take TRT decisions as seriously as the others you get to make.

@pesquallie
Again, this is true only for people with milder cases of prostate cancer, If you could call any case that. If you have an aggressive case of prostate cancer, then eliminating testosterone can help a lot to stop the cancer from growing and spreading.

Yes, at some point testosterone may help but it sure doesn’t do that in the First few years for people with aggressive cases.

I have an aggressive, genetic problem BRCA2 and staying on ADT kept my PSA undetectable for 2 1/2 years. The introduction of extra testosterone would’ve accelerated the growth of my cancer and also endangered me for breast cancer.

I’m 76. Just completed 5 SBRT. I had a 6 month Lupron injections on April 30. I had a 3+4 Gleason. Had a Turp a year ago which the biopsy showed maybe some cancer. Through 9 months of MRI, perineal biopsy etc with concern it had metastasized. So I started the Lupron out of fear. Then found no metastasized anything. The side effects of the radiation have been minimal, some bowl issues that cleared with anti-diarrhea pills.

The side effects of Lupron are another story. I can handle the night sweats, foggy brain, all joints aching & lack of energy as I’ve always weight lifted and continue to force myself to work out (which always make me feel better). But I’m worried about muscle bone & sex drive loss. My original RO wanted to do the lower dose plus 18 months ADT.

After reading up and my age and having lived Lupron for going on 5 months, there is no F-ing way I will go on it again or ever consider 18-24 months, I’d be a shell of a person. I’ve also read lately that some studies without Lupron that SBRT still works. I see my RO in 3 months for a PSA and follow up.

@utahgearhead
With only a 3+4 you probably do not need to have ADT any longer. The guidelines pretty much do not call for it For an extended period of time, unless you have some aggressive issues.

Update. Hubby on Lupron every 3 months still. Nubeqa given 300mg daily to start first month all okay, second month 300mg twice daily appeared to be okay. Psa was 0.09. Last night he had what I would consider severe shaking possibly a seizure scared me to death. I wasn’t sure what to do call ambulance? So I waited and after 30 minutes or less he was okay. I am not crazy about taking him to the hospital since the last time they restrained him since he has moderate dementia which has caused him to dream and wake up thinking he is still in his dream. Emailed oncologist who has taken him off the nubeqa and also neurologist who has taken him off his low dose aricept. Has anyone else had the shakes or seizures with nubeqa? When I called onco pharmacy she said there are no side effects like this, I suggested she read them?

Third month of nubeqa for hubby, last night he had severe shaking possibly a seizure dr has taken him off it for now since during that time his psa went to .0.09

Greetings!

I'm pushing 75 now, and have 'localized' recurrence (per recent PSMA-PET scan), following "triple-play" treatment (ADT, brachytherapy and beam radiation), eight-years ago. I was only administered Lupron twice, immediately after diagnosis (and short-term immediate Casodex), and just before heading home after the completion of the other two treatments.

I was cancer-free until this past January, but my PSA has jumped from 4.5 to 13.4, over the last eight months, and I'm likely facing Orgovyx, and possibly Abiraterone as well. I'm not quite sure on either just yet? It is my understanding that the former blocks testosterone at the receptor cell, while the latter med literally stops its production, but I certainly will not do Lupron again, regardless! I may have been an outlier or oddity of some sort, but I had terrible side effects from it, including horrific nightmares and outright hallucinations at-times. So I understand your rationale completely.

Best of luck to you!

@toomany

Same issues with Lupron. It destroys every organ in your body and statistically only increases survival by 5%.