MCI with small vessel ischemic disease: Leqembi good option?

Posted by gretone14 @gretone14, Aug 17 5:58pm

My wife is being treated for MCI the last two years. Her MRI shows memory loss with small vessel ischemic disease. She currently is taking 10mg 2x/day of memantine. Her PET Scan in May 2026 showed frequent amyloid neuritic plaques and her Centaloid level was 108.2. She had APOE genotyping bloodwork done in July that showed E3/E4 genotype & positive for APOE E4 which reflects increased risk for late onset Alzheimer's Disease.
Her MoCA (Montreal Cognitive Assessment) score is 19/30 A MOCA which indicates mild cognitive impairment or possible early dementia, suggesting significant deficits in one or more cognitive domains and warranting further comprehensive evaluation and medical assessment. They say the normal threshold is 26 or higher on the Montreal Cognitive Assessment. Her neurologist wants to start her on Leqembi infusion ASAP. Is this a good option for her (us)? Thanks.

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Welcome @gretone14. I moved your post into its own discussion in the Caregivers: Dementia group so you can connect with other caregivers.

You may be interested in this related discussion and expert blog post:
Discussion
- Leqembi: Anyone else taking this infusion to slow dementia?https://connect.mayoclinic.org/discussion/leqembi/
- Leqembi (lecanemab) Approved: What Does It Mean for You?https://connect.mayoclinic.org/blog/living-with-mild-cognitive-impairment-mci/newsfeed-post/leqembi-lecanemab-approved-what-does-it-mean-for-you/

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Welcome @gretone14. I moved your post into its own discussion in the Caregivers: Dementia group so you can connect with other caregivers.

You may be interested in this related discussion and expert blog post:
Discussion
- Leqembi: Anyone else taking this infusion to slow dementia?https://connect.mayoclinic.org/discussion/leqembi/
- Leqembi (lecanemab) Approved: What Does It Mean for You?https://connect.mayoclinic.org/blog/living-with-mild-cognitive-impairment-mci/newsfeed-post/leqembi-lecanemab-approved-what-does-it-mean-for-you/

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@colleenyoung You guys are great the way you link these articles for us. Thanks. Best, Karla

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