1. < MAC & Bronchiectasis
Profile picture for sarahlynn1960

Tobramycin questions

Posted by sarahlynn1960 @sarahlynn1960, Aug 8 3:51pm

I was on Tobramycin for abt a week before I stopped due extremely sore mouth and constant coughing with tons of mucus. It been 3 weeks now since I stopped, and I have a fever and still have congestion. I sent in a sputum sample, but meanwhile I’ve been worried that that extra mucus caused my pseudomonas to multiply. Or I may have cultivated a new infection.
It looks like all of the inhaled meds for pseudo all have that potential side effect. It just seems so counter-productive. Those of you that it helped, did yall have brace it thru all of this mess for weeks??

Interested in more discussions like this? Go to the MAC & Bronchiectasis Support Group.

Profile picture for Sue, Volunteer Mentor
Mentor
Sue, Volunteer Mentor | @sueinmn | 3 days ago
In reply to @desertdwellerjh "Re tobramycin dosing schedule - I would check w your own pulmonologist and/or pharmacist. I agree..." + (show)
Profile picture for desertdwellerjh @desertdwellerjh

Re tobramycin dosing schedule - I would check w your own pulmonologist and/or pharmacist. I agree it is difficult to stay on the every 12 hour dosing schedule but at the same time maintaining the level of the dose is important so the drug continues to zap the pseudomonas aeruginosa. A dip might give the darned thing an advantage. An 16-18 hour gap before the next dose seems excessive when on a twice a day dosage.

Jump to this post

@desertdwellerjh The half-life of Tobramycin is only 2-3 hours, so the 12 hour dosing is not as critical as with some medications. When I was using it the ID doc was specific that the doses be at least 10 hours apart, so I used it at noon and 10 pm (it could not be taken at the same time as other meds I was using so this interval worked for me.) It eradicated my pseudomonas in one month after 2 other antibiotics failed.

REPLY
2 replies
Profile picture for desertdwellerjh
desertdwellerjh | @desertdwellerjh | 3 days ago
In reply to @sueinmn "@desertdwellerjh The half-life of Tobramycin is only 2-3 hours, so the 12 hour dosing is not..." + (show)
Profile picture for Sue, Volunteer Mentor @sueinmn

@desertdwellerjh The half-life of Tobramycin is only 2-3 hours, so the 12 hour dosing is not as critical as with some medications. When I was using it the ID doc was specific that the doses be at least 10 hours apart, so I used it at noon and 10 pm (it could not be taken at the same time as other meds I was using so this interval worked for me.) It eradicated my pseudomonas in one month after 2 other antibiotics failed.

Jump to this post

@sueinmn wow! Thank you. Interesting indeed. I stayed on the 12 hour schedule (once in awhile it was 10 or 11 but rarely because I was scared re the pseudomonas diagnosis). So far after 28 days I tested negative.

REPLY
Profile picture for toni4501
toni4501 | @toni4501 | 2 days ago

It can be uncomfortable but it’s doing its job. I’m sorry to hear you stopped taking it because you won’t establish whether it was successful. I would consult with your doctor and see if you can try again

REPLY
Profile picture for toni4501
toni4501 | @toni4501 | 2 days ago
In reply to @becleartoday "I use the PARI LC Sprint cup with my travel PARI Trek S nebulizer. It’s a..." + (show)
Profile picture for becleartoday @becleartoday

I use the PARI LC Sprint cup with my travel PARI Trek S nebulizer. It’s a good nebulizing cup, and I appreciate that while traveling, I can sterilize it using high heat.

At home, however, I prefer the breath-actuated AeroEclipse XL BAN. Because it releases mist only when I inhale, I’m not putting as much aerosol into my home air or wasting as much saline or medication.

My husband appreciates that I’m considerate, especially since we live in a small apartment. When I visit my daughters and grandchildren, who have pets, I also feel that I’m doing the responsible thing by controlling how much medication mist is released into the air.

The AeroEclipse does take a little longer than the PARI cup. If I’m in a hurry, rather than switching it to continuous mode and releasing more mist into the room, I may simply stop nebulizing a little earlier.

The manufacturer also explains that a small amount of solution should remain in the bottom of the AeroEclipse cup. I think some people try to nebulize every last drop, and that may be one reason it seems to take so long.

Just some food for thought!

Warm regards,
Linda Esposito

Jump to this post

@becleartoday I find the different nebulizing cups are very confusing it as much as which one is the best. The. Pari seems to waste a lot of the medication. After being at NJH, I was advised to use the AeroEclipse so there isn’t a loss of medication and it delivers a smaller particle which would be advantageous for lung absorption. What is your opinion on this, Linda?

REPLY
Profile picture for lenorj
lenorj | @lenorj | 2 days ago

My experience , with the approval of my pulmonologist is that do s 6-8 hrs apart are fine. Just be consistent with 2x per day, spaced as much as possible. Better to have the 2 does rather then miss one because of timing.

REPLY
Profile picture for vstankie
vstankie | @vstankie | 1 day ago
In reply to @sueinmn "@desertdwellerjh The half-life of Tobramycin is only 2-3 hours, so the 12 hour dosing is not..." + (show)
Profile picture for Sue, Volunteer Mentor @sueinmn

@desertdwellerjh The half-life of Tobramycin is only 2-3 hours, so the 12 hour dosing is not as critical as with some medications. When I was using it the ID doc was specific that the doses be at least 10 hours apart, so I used it at noon and 10 pm (it could not be taken at the same time as other meds I was using so this interval worked for me.) It eradicated my pseudomonas in one month after 2 other antibiotics failed.

Jump to this post

@sueinmn are you saying tobramycin killed off the pseudamonas in your lungs. I was on Tobi many times, it never killed it.

REPLY
1 reply
Profile picture for sarahlynn1960
sarahlynn1960 | @sarahlynn1960 | 1 day ago

Im very interested I. This question too, since inhaled Tobramycin was so difficult for me. I was originally on the regular Tobramycin, which I quit due to what I thought was extreme mucus production. I’ve received an order of the podhaler form of Tobramycin, but have not started it. I’m going to NJH on Sept 8, so I will talk it over there. If I could get rid of pseudomonas with these drugs which create such extreme mucus congestion, I would go for it. But I don’t want to go thru that otherwise. It was bad when I tried it. Has anyone had this irritation and mucus get better as treatment went on?

?

REPLY
Profile picture for Sue, Volunteer Mentor
Mentor
Sue, Volunteer Mentor | @sueinmn | 1 day ago
In reply to @vstankie "@sueinmn are you saying tobramycin killed off the pseudamonas in your lungs. I was on Tobi..." + (show)
Profile picture for vstankie @vstankie

@sueinmn are you saying tobramycin killed off the pseudamonas in your lungs. I was on Tobi many times, it never killed it.

Jump to this post

@vstankie I guess I was among the fortunate people whose infection was sensitive to the drug. We are all different. My spouse cleared the pseudomonas with the first course of doxycycline, and it has never come back.

REPLY
Profile picture for sarahlynn1960
sarahlynn1960 | @sarahlynn1960 | 1 day ago

Did you both have extreme mucus and coughing during the treatment? Did it ever get better?

REPLY
Please sign in or register to post a reply.