Anyone’s loved one had an allergic reaction to infusion therapy?

Posted by jwarren @jwarren, Aug 21 7:05am

Anyone’s loved one had an allergic reaction to infusion therapy?

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My husband is on the 24th lequembe infusion and hasn't experienced any allergic reaction - so far.
Best, Karla

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Great news! My wife’s second Kisunla infusion.

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My wife has had the initial round of 18 Kisunla infusions and no allergic reactions or ARIA reactions. Her memory hasn’t gotten any worse over this last year and a half nor have any other Alzheimer’s symptoms manifested, so I consider this a win. The post treatment PET scan showed major reduction of amyloid in two primary Alzheimer’s specific regions which are the strongest predictors of cognitive decline but there is still enough in other regions that the neurologist feels can benefit from continued treatment. She just began a 12-infusion treatment to continue to chip away at the amyloid, as amyloid is somewhat of a beginning “seeding” process that provides the environment for tau tangles, the other main Alzheimer’s condition. We considered getting her in a tau treatment trial but as she has responded so well to the Kisunla treatment and there is more that can be done there, combined with the unknown plus the 50% chance she would get a placebo for the two and a half year tau study, we felt continuing Kisunla is a better option.

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That is very encouraging. I hope we achieve your wife’s success. Thanks!

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Profile picture for wajs @wajs

My wife has had the initial round of 18 Kisunla infusions and no allergic reactions or ARIA reactions. Her memory hasn’t gotten any worse over this last year and a half nor have any other Alzheimer’s symptoms manifested, so I consider this a win. The post treatment PET scan showed major reduction of amyloid in two primary Alzheimer’s specific regions which are the strongest predictors of cognitive decline but there is still enough in other regions that the neurologist feels can benefit from continued treatment. She just began a 12-infusion treatment to continue to chip away at the amyloid, as amyloid is somewhat of a beginning “seeding” process that provides the environment for tau tangles, the other main Alzheimer’s condition. We considered getting her in a tau treatment trial but as she has responded so well to the Kisunla treatment and there is more that can be done there, combined with the unknown plus the 50% chance she would get a placebo for the two and a half year tau study, we felt continuing Kisunla is a better option.

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@wajs Great story and continued success. Is the new 12 infusion protocol also with Kisunla? I just completed my 18 Kisunla infusions but I didn't know there was a possibility of a maintenance program also. Thank you for your help...Joe

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Yes, Joe, it is with Kisunla. I also wasn’t aware of a maintenance program either but that might just called that (maybe in the nomenclature of insurance??) but it truly is more of a continuation to clear out additional amyloid plaque (versus keep it away). Best of luck to you.

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