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Is Vitamin K2 OK with Eliquis
Hope someone can help by answering a question. I'm post-ablation (a-fib)--am on rhythm medication and Eliquis 5 mg BID. I'm also osteopenic and 77 years old. I've tried calcium in the past but don't do well on it. Constipation is an issue and as I've had a hemi-colectomy and I've avoided calcium. When in the health food store this week to get my D3, I saw the D3 with K2 for bone, heart... It seems it is different that calcium supplements. I would like to be taking something for my bone health. I searched the Mayo connect site but most of what I saw was pretty old. Thanks for any help or guidance.
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@linfor13 Welcome to Mayo Connect, where patients support one another on their health journeys. We are not medical professionals, and cannot advise you what is best on your personal situation.
Whenever one is currently taking medications, the question of whether a supplement is okay should be addressed to the prescribing doctor or possibly to your pharmacist. This is especially important when one is using an anti-coagulant to reduce clot risk. Although Vitamin K2 is thought to be "safer" than Vitamin K1, it can affect the clotting factors.
@vosgor Wonderful that you are managing bone health and breast cancer so well. Have to do some serious research on the Marodyne later. For now, though, I wanted to reply because some of our history is similar. I have IDC ER+ Grade 3 diagnosed in Sept 2024 and take letrozole and Kisqali. Because my FRAX score was relatively high for hip fracture risk, I was diagnosed with osteopenia for several years prior to the BR CA dx, and would be on letrozole for years, my oncologist recommended some type of bisphosphonate. I reluctantly agreed that I should have the Zometa infusion because other oral meds and Prolia were ruled out by me.
About a year before the BR CA dx, I was diagnosed with paroxysmal atrial fib. Scheduled for an ablation in October 2024 but had to cancel that because that was when I was diagnosed with the BR CA. After going through chemotherapy and surgeries, was able to have the ablation in Sept 2025. Despite the ablation I'm continuing on the Eliquis because CA itself and the chemotherapy as well are, what one of my cardiologists call, cardio-toxic, ie., hard on your heart. And that doesn't even take the Kisqali into account.
There is a part of me, however, that would love to drop the Eliquis and am considering it later; the electrophysiologist who did my ablation thinks I could self monitor using a smartwatch or with a surgically implanted device that his office monitors.
Before all that, I did take nattokinase and K2 in both the MK4 and MK7 versions. With the onset of afib, however, the idea of MK7 doesn't seem wise since some people seem to have heart palpitations on it. I also chosen to try MK4 again because the Japanese use it to treat osteoporosis, though at a fairly high dosage of 45 mg/day.
I have spoken with my cardiologists, oncologist, and specialty pharmacist about the safety of taking K2 in the MK4 form and all said they thought it would be okay. Honestly, I don't think they knew much about it at all. I also checked with Claude AI and it appears safe, though always with the caveat to discuss with your doctor.
I started MK4 a few weeks ago and cross my fingers it will help. I mention this so that you take a closer look at the types of K2. Best of continued luck with everything!