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What's your experience wtih Brinsupr (brensocatib)?

Posted by scoop @scoop, Sep 29, 2025

It seems a bunch of us have started Brinsupri. Let's use this thread for discussion. If you are taking Brinsupri have you noticed anything different, including changes to bronchiectasis or side effects? How long have you been on it?

Interested in more discussions like this? Go to the MAC & Bronchiectasis Support Group.

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cissa | @cissa | Jul 2 2:12pm
In reply to @whitemarsh "BRINSUPRI is to be delivered tomorrow 10/01, via UPS. Yes, I have to sign for it...." + (show)
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BRINSUPRI is to be delivered tomorrow 10/01, via UPS. Yes, I have to sign for it. The ordering process has taken 10 days from when Dr Kanj put through the request. The preauthorization by Medicare/United Healthcare took a few days due to the weekend. AMBER pharmacy, based in Omaha, texted me and I was instructed to go to their link. Once all “paperwork “ was completed I was told my co-pay for 30 pills was $906. Apparently it’s $7,000 + if out of pocket! Luckily AMBER gave me information about filing for a grant: The Assistance Fund.
I went to the website, filled out the application, and was approved a few hours later. My co-pay is 0. In addition to Bronchiectasis I have MAC and will probably be starting “The Big Three” in December. Would be interested to hear from anyone who has started BRINSUPRI and is on antibiotics for MAC.

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@whitemarsh
I have BE and MAC. I started the 3 antibiotic treatment in September '25 and Brinsupri in December '25. I'm tolerating the antibiotics well as long as I keep up the daily kefir and the only negative with the Brinsupri is mild headache on occasion.

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kristia | @kristia | 21 hours ago

I am starting my second month on Brinsupri. (I have Bronchiectasis and MAC. ) I am experiencing a reduction in sputum. I find it helpful to photograph with my iphone what I cough up periodically with a penny next to it to gauge size, to track what is happening, and document for my pulmonologist rather than rely on verbal descriptions.

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Sue, Volunteer Mentor | @sueinmn | 13 hours ago
In reply to @kristia "I am starting my second month on Brinsupri. (I have Bronchiectasis and MAC. ) I am..." + (show)
Profile picture for kristia @kristia

I am starting my second month on Brinsupri. (I have Bronchiectasis and MAC. ) I am experiencing a reduction in sputum. I find it helpful to photograph with my iphone what I cough up periodically with a penny next to it to gauge size, to track what is happening, and document for my pulmonologist rather than rely on verbal descriptions.

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@kristia Hello, I see you have been around Connect for a bit, I'm glad you have good news to share in your first post. We have moved it to a continuing discussion where those using Brinsupri share their experience with the rest of us.

How long have you been living with Bronchiectasis? What else do you do to stay healthy?

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diziggy | @diziggy | 1 hour ago

I was diagnosed with BE about 2years ago and MAC about a year ago. I have been on Brinsupri for 6 months. The only side effect I have had is some dry patches on my skin. My last scan showed no advancement so I consider that a win. Because of this, my pulmonologist and I have decided not to put me on antibiotics for the MAC. I nebulize and do a nasal rinse twice a day. I feel this plus the Brinsupri are keeping me stable.

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