What biologics treat Crohn’s and what if they fail?

I have PPMS and crohns and currently take two biologics (ocrevus and entyvio). I dealt with sepsis in Jan of this year and feel what caused it was the combo of biologics shutting my immune system down and constipation from the crohns. Since then my GI tract doesn’t appear to be functioning the same and my gastro doesn’t seem interested.Has anyone else had issues while on two biologics or entyvio specifically….

@brhb2011 - welcome to Mayo Clinic connect. I moved your post to join others who were discussing biologics and Crohn's so you could interact with them in this discussion:

- What biologics treat Crohn’s and what if they fail?https://connect.mayoclinic.org/discussion/what-biologics-treat-crohns-and-what-if-they-fail/

Did your PCP or your gastroenterologist think the sepsis was due to your biologics?

@lisalucier my gastroenterologist fought tooth and nail to deny my sepsis was GI related even though all tests pointed to my GI tract. They waited to do a follow up colonoscopy until post hospitalization plus 6 weeks of steroids so of course once the test was done my GI looked fantastic.

My gastroenterologist is stubborn, like most specialists, so my pcp actually just sent a referral to the Mayo for a second opinion.

@brhb2011 I was on Entyvio for a short time. I had a bad reaction to either it or possibly another medication. (Sometimes is hard to tell if you have more than one heavy duty drugs in your system. ) I’m fairly certain entyvio caused my GI tract to stop functioning. It caused my stools to be ribbon thin. I’m still struggling with constipation after a SIBO. I’m thankful a Nateralpath dr is helping bc GI dr was not. I’m so sorry you are dealing with so much! Sending prayers and good thoughts.

@annpeters im on my last patience with entyvio. I’m hoping I have an allergic reaction to entyvio, in the hospital, so then I can just be done. Hahahaha

My general dr is referring me to the Mayo since my gastro is being stubborn.

@brhb2011 my GI doctor gave me Benadryl IV before receiving Entyvio infusions. After about 5 infusions I refused the Benadryl and did fine without it. Entyvio worked for me for almost 5 years. Then I went on Stelara but had to come off of it because I kept getting very sick—influenza A, bilateral pneumonia with sepsis beginning, pneumonia again all within 16 months. I had remission for 2 years, now I’m on Tremfya, and I seem to tolerate it well. I hope you find a treatment that works. I’m here to tell you It ain’t easy.