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Have stage 4 NSCLC being treated with Targeted Therapy, Any one else?

Posted by kenber45 @kenber45, Aug 13 12:15pm

Would love to hear from others who may be having this treatment or have had it in the past. Here's my story:
Long time smoker, had a cough for a few months and then started getting short of breath. Chest Xray showed Pnuemonia, recommended CT Scan of the Chest, CT showed left lower lobe mass, Right hylar mass and swollen lymph nodes, right upper lobe mass. Recommended CT PET Skull Bass to Knees, PET CT showed metabolic activity in the lung areas and mediastinum. No other organ Involvement. Recommended Biopsy. Pulmonologist biopsied all suspected area's of the lung and ordered a Circulogene Blood test to look for genetic variants in tumor cells to make Targeted Therapy possible. Biopsy showed Left lobe was cancer. Lymph modes were Positive for Cancer cells. Right lobe was Negative. Mayo oncologists ordered brain MRI prior to consultation and Brain Mri showed 6 small metastatic lesions in my brain. Being treated with Lazertinib and amivantamab for the EFGR variant I have. Please share if you have experience with this. Thanks

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lala56 | @lala56 | Aug 19 10:03am

Similar journey. I'm also grateful for having Tagrisso target therapy ( same S/E) I'm always curious what comes after Tagrisso treatment. I feel very comforted being on target therapy that is fairly well tolerated. It's been a year for me and I'm feeling very close to my normal self. I've been through RLL surgery, chemo for 8 cycles every 21 days and now on Target therapy. I'm so grateful everyday for the present . Wishing everyone with same journey the best and believe God is good.

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Lisa, Volunteer Mentor | @lls8000 | Aug 20 1:34pm
In reply to @lala56 "Similar journey. I'm also grateful for having Tagrisso target therapy ( same S/E) I'm always curious..." + (show)
Profile picture for lala56 @lala56

Similar journey. I'm also grateful for having Tagrisso target therapy ( same S/E) I'm always curious what comes after Tagrisso treatment. I feel very comforted being on target therapy that is fairly well tolerated. It's been a year for me and I'm feeling very close to my normal self. I've been through RLL surgery, chemo for 8 cycles every 21 days and now on Target therapy. I'm so grateful everyday for the present . Wishing everyone with same journey the best and believe God is good.

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Hi @lala56, Asking 'what's next', after a treatment no longer works is normal, and can be helpful. Having an idea of what I would do next helps me get through scans. I take a different targeted therapy for ALK positive lung cancer, stage IV. I too know that my cancer will eventually develop resistance. Thankfully, there are therapies being approved now that didn't exist when I was first diagnosed. We need the advancements in treatments to stay ahead of our needs. Fingers-crossed! Have you asked your oncologist what to expect as a next treatment?

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Colleen Young, Connect Director | @colleenyoung | Aug 26 1:49pm
In reply to @kenber45 "I have had 3 weekly Subcutaneous injections of the Rybrevant and been on the Daily Lazcluze..." + (show)
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I have had 3 weekly Subcutaneous injections of the Rybrevant and been on the Daily Lazcluze for 1 week. Prior to starting the Rybevant I was very short of breath and coughing allot. Literally after the first injection those symptoms subsided and have not returned. The only side effect Ive had has been some minor rash issues around my eyebrows and forehead. They gave me a plethora of soaps and moisturizers to use prophalactivly which I have done. Both my Mayo and local Oncologists felt the benefit of adding Chemo drugs to the Targeted Therapy drugs would not be worth the quality of life issues associated with that combo. I'll get a follow up scan in a month. Im very confident my tumors will be much smaller or gone as the dramatic relief of my pre treatment symptoms indicates it's working well. I feel so good! If this is as bad as it gets I am most blessed! Thanks everyone! Praying for you all.

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@kenber45, you might be interested in this related discussion:
- Anyone on Rybrevant (amivantamab-vmjw) for advanced NSC lung cancer?https://connect.mayoclinic.org/discussion/anyone-on-rybrevant-amivantamab-vmjw-for-advanced-nsc-lung-cancer/

You're on both Rybrevant (amivantamab-vmjw) + Lazcluze (lazertinib), right?

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