Priming Tymlos pen?
Hi, I've read through lots of posts about starting Tymlos at a lower dose and that's what I'm going to try. One question I can't find the answer to: the directions say to prime the for the full dose. Is that ok to do if I plan to start with 4 clicks? Or should I also prime with only 4 clicks? Thanks in advance for any advice!!
Interested in more discussions like this? Go to the Osteoporosis & Bone Health Support Group.
Connect

@alidamc The 80 that appears is the only number you will see (when you twist the green dial all the way, which is 8 clicks).
-
Like -
Helpful -
Hug
1 Reaction@alidamc "Priming" just means you release the first dose on a new pen without injecting it. Here's the process for a new pen. Apologies if this seems ridiculously detailed, but I want to make sure that we're all clear on what is happening with your pen. 🙂
1. Put a new needle on the pen.
2. Pen says zero. Turn it to 80 (which is the maximum dose)
3. Press the button to release the first dose. (I used to do it over the sink just in case.)
4. Pen says zero again. Turn it to 80 again.
5. Give yourself the injection.
Repeat 1,2,5 every day.
-
Like -
Helpful -
Hug
2 Reactions@alidamc
Normally almost anywhere you have some extra subcutaneous fat is okay for other meds but there are some particular reasons why Radius Tymlos guidance is lower abdomen only 2 inches from belly button and or scars like an appendix scar. The abdomen is one of the largest per square inch areas of subcutaneous fat aided in better absorption of the drug.
John’s Hopkins says:
The abdomen is a common site for subcutaneous injections due to the layer of fat present, while the flank is less commonly used and may not be as effective for certain medications. It's important to follow the guidance from the drug manufacturer…they will have instructions on the best injection sites.
@john78109
This tip is important because of the “back pressure” after inserting the needle and pressing the plunger it takes a bit for the medicine to completely be released subcutaneously.
@osteopatient2026 personally I would prefer to give the injections in my derrière, lol.
@osteopatient2026 One thing I didn't realize the first time I tried the pen: when you press the plunger all the way down, you can stop pressing. It stays down. That makes it easier to count to ten.
-
Like -
Helpful -
Hug
1 Reaction@njx58 GOT it. Thank you so much.
-
Like -
Helpful -
Hug
1 Reaction@njx58 I don’t count to ten. I plunge it in and get it over with. The fact that I am even using a needle to give myself an injection is a small miracle. I take anti-anxiety med before I do it because it is so difficult for me.
@alidamc
You might not be getting necessary dose to be effective doing that. Can you get a volunteer to help give them to you? I understand I’m lucky I have my husband do them for me…I’m not sure I could do it either.
@njx58 …gee that’s a great tip. So much to know. Thanks!