Pain in leg muscles, tendons, and knees after Bilateral PE on Eliquis

Posted by smasneri @smasneri, Jul 6, 2023

One month after massive bilateral PE and taking 5 mg twice daily. Experiencing constant and continual pain in legs, mainly behind both knees, in tendons, and some muscle flare ups. Have had two ultrasounds and a CT scan on both legs since I was diagnosed June 6 and they are negative. My D Diemer is .43 and all vitals strong and regular. Echocardiogram shows no strain on heart. We have ruled most everything else out. No trauma to legs, no cuts, bruises or strains. Is this related to the Eliquis? My local hematologist wants me on it for another 5 months, I won’t be able to make that unless this subsides. Anyone else out there having this issue? Recommendations?

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Tried compression socks? Also having a good pair of shoes like Hoka’s will help. Elevation along with Tylenol has been helping me.

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Profile picture for cyclocross @cyclocross

Competitive cyclist for over 30 years years, had a slight mishap 11 years ago at a training race and developed a small blood clot in my left leg. Was on Xarelto for six months, after the six months did another sonogram and the clot was clear so I was taken off Xarelto and put on baby aspirin.
11 years later I developed another one behind my knee. Being 64 years old and still very active I had no idea how this developed this other than “over training.“ during the winter.
Now on Eliquis 5 mg twice a day and feel absolutely horrible. The pain I am experiencing in my leg, shoulder, wrist and knee is borderline unbearable. I try not to take Tylenol too much as I value my kidneys. My blood work and cardiac testing are 100%, no issues at all.
Not sure if I want to stay on Eliquis at all due to the side effects.
Looking for a sensible answer as I do not trust the doctors anymore.

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@cyclocross
I’m wondering why they put you on Eliquis when you had mentioned the first blood clot you had you were on Xarelto and it cleared…

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I've been on Eliquis for 3 months for a DVT, and since then I've developed constant pain bilaterally in my hips, knees and hands. Nothing helps. I've had CTs, MRIs, Xrays, even a Nuc Med Scan. They can't find anything to explain the pain.

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Profile picture for edv @edv

Your comment are very interesting. Since starting Eliquis I have developed significant joint pain with the worst being hands/wrists and neck plus feeling ‘off’ in the mornings in particular. As the day goes on I get better but still have pain. The marker for inflammation also has gone way up along with my WBC. Haven’t yet spoken with PCP and cardiologist about it but will be soon. I dint feel like working out and I know I could not lift weights of any weight so getting weaker.

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@edv I've been on Eliquis for 3 months and I've delveloped bilateral hip, knee and hand pain. Nothing helps. I've had all kinds of imaging and they can't find anything wrong. I had some elevated inflammatory markers, but the rheumatologist said I do not have RA, lupus or anything else.

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Profile picture for jeannelr @jeannelr

Just joined after reading about leg pains and Eliques. Yes, me too and miserable. I am now using Epson Salt packs to alleviate pain but it is short lived. Ice and a heating pad also helpful for a few hours. Mostly walking a few miles a day wont work for the pain after 3/4s of a mile. Any suggestions?

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@jeannelr, glad you joined. Welcome to Mayo Clinic Connect.

I am glad to hear you are finding a bit of relief, if only for short periods of time.

Have you had a chance to ask your prescribing doctor for recommendations?

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Profile picture for tamroles @tamroles

@edv I've been on Eliquis for 3 months and I've delveloped bilateral hip, knee and hand pain. Nothing helps. I've had all kinds of imaging and they can't find anything wrong. I had some elevated inflammatory markers, but the rheumatologist said I do not have RA, lupus or anything else.

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@tamroles I was wondering the same thing. I also am having more brain fog, since being on Eliquis. I've been on it 5 months, and having a lot of hip, and joint and muscle pain, and painful spasms, on and off. I have had to take a arthritis Tylenol almost every day. It helps some. Right now, I'm having pain in my left hip and shoulder. It is hard to put my pants and socks on because it is painful in that hip. I hope they can help you.

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I have been on Eliquis for a few years, had right hip replacement a year ago now have pain in right groin and hurts lifting leg into car and putting on sock. Also have numb feet (perifehal neuropathy)Could all this being caused by the eliquis

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Profile picture for rostrevor @rostrevor

I have been on Eliquis for a few years, had right hip replacement a year ago now have pain in right groin and hurts lifting leg into car and putting on sock. Also have numb feet (perifehal neuropathy)Could all this being caused by the eliquis

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@rostrevor Yes, that sounds just like me. I struggle with putting on underwear, pants, socks, etc, because of the pain in hip and groin. I guess it is arthritis, I guess. I don't know if it is the Eliquis. I was having terrible pains in that leg, and then found out about the extensive blood clot in that leg that needed surgery to remove it. And because I have the Fac5Leiden clotting factor, the doctor insists on Eliquis. But I truly hate taking it and worrying about hurting myself and bleeding. I sit in the car first, and then use my hand to lift my leg. It still hurts, but not as much if I try to lead with that leg. And I use biofreeze and a heat pad. But have you checked with the doctor that did your surgery to make sure everything is ok with the replacement?

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Profile picture for cad43 @cad43

@rostrevor Yes, that sounds just like me. I struggle with putting on underwear, pants, socks, etc, because of the pain in hip and groin. I guess it is arthritis, I guess. I don't know if it is the Eliquis. I was having terrible pains in that leg, and then found out about the extensive blood clot in that leg that needed surgery to remove it. And because I have the Fac5Leiden clotting factor, the doctor insists on Eliquis. But I truly hate taking it and worrying about hurting myself and bleeding. I sit in the car first, and then use my hand to lift my leg. It still hurts, but not as much if I try to lead with that leg. And I use biofreeze and a heat pad. But have you checked with the doctor that did your surgery to make sure everything is ok with the replacement?

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@cad43 surgery was told was 100% okhe says it is caused by tendon.Awaiting mri or maybe cortisone shotc

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Profile picture for rostrevor @rostrevor

@cad43 surgery was told was 100% okhe says it is caused by tendon.Awaiting mri or maybe cortisone shotc

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@rostrevor I am also thinking that I might get a shot if it continues. I had a callous on my toe and the podiatrist removed it and gave me a gel sleeve to wear on that toe during the day. But it is a real struggle putting it on and off and then trying to get a sock over it, because of so much pain in the hip and groin. So I don't wear it anymore. I think it adds to the pain because of the position of my leg doing that.

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