Is anyone else taking Lynparza (olaparib)? How are you doing?

@ginmav This is good news. I’m happy for you that you feel better on the reduced dosage of Lynparza. The loose bowels? I have this off and on but it’s stress-related for me. I know how unpredictable and awful this is. Hopefully your experience is predictable enough that you know when you need to be home and near your bathroom.

Are you able to get back to walking? Other things you enjoy that you now do because you feel less fatigue?

I still tire easily but at least I now can take walks and do things around the house. The other day I even enjoyed shopping. But I do listen to my body.

If my other issue would settle down I would be terrific.

How are you doing?

Following this as PARP inhibitors are used off label for 4b cervical cancer - my genetic tests show high LOH which is apparently an indicator for things like platoon.

Late August 2025 I was diagnosed with ovarian cancer. Chemo began early October, 3 infusions every 3 weeks. In December total hysterectomy and in February 2026 resumed chemo, again 3 infusions every 3 weeks. My latest CA125 is at 10 (it was over 1400 when diagnosed) but my oncologist discussed with me that due to a marker he recommended I take Lynparza. And he actually is involved with a clinical trial which is studying the benefits of taking Lynparza 2 years or if 1 year will be sufficient. I have not yet started taking Lynparza, but will be starting next week as I just received the phone call that I have been accepted to join the trial. I hopped on the computer to search for a group such as this. My chemo experience was bad but manageable, but the worst side effect occurred about 2 days before my last chemo infusion. Neuropathy so bad that there were days I could not even stand let alone walk. I am still dealing with it but it has gotten better. I am concerned that the Lynparza will be a setback on my improvement. Has anyone else experienced neuropathy while taking Lynparza?

@kdmsk8s, welcome and congrats on getting into the trial. Neuropathy is not usually a side effect of Lynparza (olaparib), although I would discuss the risk of worsening neuropathy with your oncologist. It sounds like neuropathy is getting better with time for you and I can understand your concern about it getting worse again.

Have you started Lynparza treatment now? How are you doing?

@lleenyoung

I have been on Lynparza for a year. I have neuropathy but it was from the chemo. The Lynparza did not make it worse.

I hope you keep posting about your trial.

Did you keep your hands and feet pretty much frozen when you got your taxol infusions?

My daughters kept refilling ziplock bags with ice from the nurses station and I stayed very cold the entire three hours. The gloves and footies from amazon didn’t stay cold long enough so that’s why we switched to ziplock bags. I don’t have any neuropathy and am so sorry you are having trouble with it.

I’ve been on Avastin infusions once every three weeks and lynparza 250 mg twice a day since May and my biggest side effect now is how it messes with my taste buds and appetite. There is some fatigue but not like when I was on the full dose, 300mg 2x/day for two months. I had to start and stop often on the higher dose.

My maintenance plan started march 5th and my scan in June showed a small spot of new growth. My ca125 and signatera results have been increasing so I’ll be starting a new plan soon. Not sure what it’ll be. Stay tuned for that, lol!

I wish you all the best from the bottom of my heart.❤️

I also tried the gloves and socks but they did not stay cold so I stopped. The infusion nurses filled ice bags for me but I still have some neuropathy.

@ginmav I’m so sorry it didn’t work for you. Hopefully it isn’t a permanent side effect. 🤞