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Is anyone else taking Lynparza (olaparib)? How are you doing?

Posted by ginmav @ginmav, Oct 16, 2025

Taking 600 of lynparza. I would like to hear from others and their side effects or just how they are feeling.

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Helen, Volunteer Mentor | @naturegirl5 | May 6 8:38am
In reply to @ginmav "After a year on Lynparza (600) my doctor reduced dosage to (500) because of fatigue. I..." + (show)
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After a year on Lynparza (600) my doctor reduced dosage to (500) because of fatigue. I feel so much better since we did that. My only other issue is loose bowels After I eat. My gastrointerologist feels it is the Lynparza.

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@ginmav This is good news. I’m happy for you that you feel better on the reduced dosage of Lynparza. The loose bowels? I have this off and on but it’s stress-related for me. I know how unpredictable and awful this is. Hopefully your experience is predictable enough that you know when you need to be home and near your bathroom.

Are you able to get back to walking? Other things you enjoy that you now do because you feel less fatigue?

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ginmav | @ginmav | May 6 9:20am

I still tire easily but at least I now can take walks and do things around the house. The other day I even enjoyed shopping. But I do listen to my body.

If my other issue would settle down I would be terrific.

How are you doing?

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kirlizee | @kirlizee | May 7 8:06am

Following this as PARP inhibitors are used off label for 4b cervical cancer - my genetic tests show high LOH which is apparently an indicator for things like platoon.

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kdmsk8s | @kdmsk8s | Jun 25 1:24pm

Late August 2025 I was diagnosed with ovarian cancer. Chemo began early October, 3 infusions every 3 weeks. In December total hysterectomy and in February 2026 resumed chemo, again 3 infusions every 3 weeks. My latest CA125 is at 10 (it was over 1400 when diagnosed) but my oncologist discussed with me that due to a marker he recommended I take Lynparza. And he actually is involved with a clinical trial which is studying the benefits of taking Lynparza 2 years or if 1 year will be sufficient. I have not yet started taking Lynparza, but will be starting next week as I just received the phone call that I have been accepted to join the trial. I hopped on the computer to search for a group such as this. My chemo experience was bad but manageable, but the worst side effect occurred about 2 days before my last chemo infusion. Neuropathy so bad that there were days I could not even stand let alone walk. I am still dealing with it but it has gotten better. I am concerned that the Lynparza will be a setback on my improvement. Has anyone else experienced neuropathy while taking Lynparza?

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