diastolic dysfunction effects and treatmetn

@asolidrock
I have grade 2 diastolic dysfunction which caused HFpEF and pulmonary hypertension. I was prescribed Jardience but it has only been about 10 days so too soon to expect change. The DD causes cardiac remodeling of the ventricle ( can be left or right) which means the ventricle becomes thicker and stiff making it hard for the ventricle to fill with blood and pump to the rest of the body. This can cause shortness of breath and fatigue and the feeling like your muscles aren't getting enough blood or oxygen.

@bch72 Sure. In early Oct 2025 I was diagnosed with grade II HFpEF at Mayo Rochester. I was told there wasn’t a lot to be done for it but that the gold standard for treatment was Jardiance. Looking at all the information I could find this seemed like the best path. I was prescribed 10mg daily and cleared to do whatever my body would tolerate. About a week in I started to notice improvement in my symptoms. I still had one or two bad days a week but that sure beat every day sucking. In early December, either my HFpEF was progressing or my body was used to Jardiance and its effectiveness decreased. I don’t know which but symptoms started to return and picked up momentum. Getting worse and worse. I was given the opportunity to enroll in Dr Borlaug’s REIMAGINE- HFpEF PERI Cut study and underwent the surgery in April. For me, it has been like someone flipped a switch. Today I am 90 days out from having had the surgery and feel superfantabulous.

@asolidrock Basically they slit my pericardium using a new type of catheter that they are trying to gain FDA approval for. I was the fourth person to have this done. Tremendous difference for me.
https://www.tctmd.com/slide/perctuaneous-pericardiotomy-preliminary-findings-pericut-catheter-system-early-feasibility
The link will take you to a PowerPoint Dr Killu did on the surgery results as of March. The registration to see the slides is easy and worthwhile.

Unbelievable I'm so happy for you. May God continue to bless your life and treasure every day as a gift from the Lord.

@bch72 Sure. In early Oct 2025 I was diagnosed with grade II HFpEF at Mayo Rochester. I was told there wasn’t a lot to be done for it but that the gold standard for treatment was Jardiance. Looking at all the information I could find this seemed like the best path. I was prescribed 10mg daily and cleared to do whatever my body would tolerate. About a week in I started to notice improvement in my symptoms. I still had one or two bad days a week but that sure beat every day sucking. In early December, either my HFpEF was progressing or my body was used to Jardiance and its effectiveness decreased. I don’t know which but symptoms started to return and picked up momentum. Getting worse and worse. I was given the opportunity to enroll in Dr Borlaug’s REIMAGINE- HFpEF PERI Cut study and underwent the surgery in April. For me, it has been like someone flipped a switch. Today I am 90 days out from having had the surgery and feel superfantabulous.

@asolidrock Thank you. For me it was as close to a miracle as I will ever come. Night and day.

@altilla
What type of surgery did you have? Could I ask what your ejection fraction was?

What type of surgery did you have?

@asolidrock
That's wonderful. I hope it continues to work for you. I'm assuming that since it was a study done at Mayo, it hasn't been FDA approved yet. I'm going to bring this up with my cardiologist. Thanks so much for the information. It's very helpful.