Treatment for Her2+ breast cancer

Posted by lban05 @lban05, Jun 25, 2025

Has anyone had Stage 1 Her2+ breast cancer and not done the recommended treatment of chemo and the targeted drug after a mastectomy?

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Profile picture for sbrown96 @sbrown96

@health77 my daughter is 30 and was just diagnosed with invasive breast cancer cancer. With.ER+PR-HER2+
She does not want chemo. She hasn’t had any children yet. Did your doctor recommend chemo? She is just desperately trying to find somewhere that would do a chemo, free treatment and hopefully be effective.

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@sbrown96, there are various fertility preservation options that may be available for your daughter before she undergoes cancer treatment. You might find this article helpful:
- Fertility considerations in cancer treatment: Preserving hope for the future https://cancerblog.mayoclinic.org/2023/08/16/fertility-considerations-in-cancer-treatment-preserving-hope-for-the-future/

Different cancer treatments can affect fertility, not just chemotherapy. She should talk to her oncologist and a fertility specialist as soon as possible. A fertility specialist can help her understand her options, answer questions and serve as her fertility advocate during treatment.

How is she doing? What treatment has been suggested for her?

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Profile picture for maggieb892 @maggieb892

I had HER2 (stage2) breast cancer. I followed all of the recommendations. I was given Paclitaxol and phesgo prior to my mastectomy and a year of herceptin and perjeta after. I faired quite well during treatment and i am 3 years post treatment with no issues

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@maggieb892 you didn't do radiation?

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Profile picture for Stuck In the 70's @jlwilcox

@maggieb892 you didn't do radiation?

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@jlwilcox i did but the question was about the chemo treatment. Possibly my situation is different than others. I had a mastectomy following the paclitaxol and radiation following the surgery because there was cancer in the tissues removed. Then the follow up with kadcyla and targeted therapy. I was told that i wouldn't have had radiation if no cancer was not found in the removed breast tissue

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I had Her2 +. I had a lumpectomy and chemo radiation because cancer was found in 3 lymph nodes. I refused anti estroden drugs. Four year later at the age of 84 my blood work shows no signs of new tumors.

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Anyone know about HER2 +LOW
Diagnosed in2022. MBC to bones. It was 95% Estrogen +. HER2 was negative. How does the cancer cell change? Radiation has worked pretty well on the lesions in the past. Dr says fulvestrant stopped working. Took it for less than a year. Any information about treatment for HER2+LOW would be greatly appreciated.

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Profile picture for raebaby @raebaby

I had Her2 +. I had a lumpectomy and chemo radiation because cancer was found in 3 lymph nodes. I refused anti estroden drugs. Four year later at the age of 84 my blood work shows no signs of new tumors.

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@raebaby Hi there from Australia... I was diagnosed last week and i have the oncologist this week.... May i ask why you did not have strogen drugs... I have no idea yet what I am in for... but you are insperational at 84... I am 55 and have 7 grandchildren ....take care

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Profile picture for leannestork @leannestork

@raebaby Hi there from Australia... I was diagnosed last week and i have the oncologist this week.... May i ask why you did not have strogen drugs... I have no idea yet what I am in for... but you are insperational at 84... I am 55 and have 7 grandchildren ....take care

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@leannestork I didn't take the anti-estrogen drugs because I had a horrible menopause emotionally. I found myself sobbing because my daughter hadn't cleaned her room at the time. I remembered that, and it wasn't worth it feeling that miserable again.
I tried the anti estrogen drugs for a short time and didn't feel well. I knew that were hard on my bones also, and I already had some bone loss.
My daughter married an Australian. She is 64 now. My grandson who was born in Australia, has recently moved back to Melbourne.
I visited there 14 times when my daughter lived there. I love Australia. You are so lucky!'Keep in touch. I'm a former registered nurse and ful of advise.

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Profile picture for raebaby @raebaby

@leannestork I didn't take the anti-estrogen drugs because I had a horrible menopause emotionally. I found myself sobbing because my daughter hadn't cleaned her room at the time. I remembered that, and it wasn't worth it feeling that miserable again.
I tried the anti estrogen drugs for a short time and didn't feel well. I knew that were hard on my bones also, and I already had some bone loss.
My daughter married an Australian. She is 64 now. My grandson who was born in Australia, has recently moved back to Melbourne.
I visited there 14 times when my daughter lived there. I love Australia. You are so lucky!'Keep in touch. I'm a former registered nurse and ful of advise.

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@raebaby Oh my goodness thankyou so so much... I have had hardware in toes, new right hip, Cage in Neck, Fibromyalgia, Lupus, 37,000 Ectopic thuds per day... 2 unsuccessful heart ablations...... and now the big C.... i am sick of the titles so i told the doctor after Alopecia and lost all my hair .... enough is enough.... the last being the C word.... surely that is the last thing and the chemo might just reset my whole system. are you on fb/messenger. I would love to keep in touch and if i can help anyone that is why i am on here sharing my journey to help others. Wishing you sunshine in your day.....cheers Leanne Stork

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Profile picture for pbnew @pbnew

Anyone know about HER2 +LOW
Diagnosed in2022. MBC to bones. It was 95% Estrogen +. HER2 was negative. How does the cancer cell change? Radiation has worked pretty well on the lesions in the past. Dr says fulvestrant stopped working. Took it for less than a year. Any information about treatment for HER2+LOW would be greatly appreciated.

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@pbnew I assume you mean HER2+ Low= as a low grade? I had HER2+ and after surgery then I was given pacitaxil, radiation and herceptin( traztuzamab) for the HER2. I was considered Grade 1A Now on Tamoxifen but strugging with weekly reactions. I was 91% ER. I believe the immunotherapy for Her2+ is golden. And it was not difficult to take over 25 treatments. Chemo, immunotherapy and radiation all seemed a breeze compared to AI's and Tamoxifen. I am 2.5 years out from surgery and all seems well.
Wishing you the best.

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Profile picture for georgemc867 @georgemc867

@pbnew I assume you mean HER2+ Low= as a low grade? I had HER2+ and after surgery then I was given pacitaxil, radiation and herceptin( traztuzamab) for the HER2. I was considered Grade 1A Now on Tamoxifen but strugging with weekly reactions. I was 91% ER. I believe the immunotherapy for Her2+ is golden. And it was not difficult to take over 25 treatments. Chemo, immunotherapy and radiation all seemed a breeze compared to AI's and Tamoxifen. I am 2.5 years out from surgery and all seems well.
Wishing you the best.

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@georgemc867
Thank you for sharing your experience. You are right. I did mean Low grade. My daughter had triple positive and went through the same treatments you did except for radiation. She also had Perjeta. I’ve had no chemo. I want to try Enhertu but the protocol in Italy where I am receiving treatment requires trying chemo first. Doesn’t make any sense to me.

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