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Treatment for Her2+ breast cancer

Posted by lban05 @lban05, Jun 25, 2025

Has anyone had Stage 1 Her2+ breast cancer and not done the recommended treatment of chemo and the targeted drug after a mastectomy?

Interested in more discussions like this? Go to the Breast Cancer Support Group.

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hwardrn | @hwardrn | Jul 2, 2025
In reply to @health77 "Glad to hear that you didn’t take the hormone inhibitors,I start my 5 weeks of radiation..." + (show)
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Glad to hear that you didn’t take the hormone inhibitors,I start my 5 weeks of radiation tomorrow and I DO NOT WANT THE SO CALLED Hormone therapy.I want to continue with my HRT which I have used for 27 years with no issues until recently.I live in Italy and I think the wine caused the cancer.Stage 1b.

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I also think my stage 1 Invasive ductal cell carcinoma was related to my wine intake and possibly combined with menopause. I was drinking more wine because of my irritability the two years leading up to menopause.
Interesting someone else links wine to it too. I really have no other risk factors.

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angiemal | @angiemal | Jul 3, 2025

My understanding is that cancer is a complex disease with many contributing factors. It's not accurate to say that wine alone is to blame — there are multiple elements that affect our immune system. That’s why integrative doctors often emphasize that cancer treatment should address various areas, including nutrition, physical activity, and mental health.

As for hormone modulating therapy (HMT), I believe it's important to recognize that side effects vary from person to person. For that reason, I think it’s worth giving HMT a chance while closely monitoring how it affects me

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bradpitt12 | @bradpitt12 | Jan 8 11:41pm
In reply to @melaniesherman "My understanding of HER2+ is that it's generally considered a more aggressive cancer. Stage 1 HER2+..." + (show)
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My understanding of HER2+ is that it's generally considered a more aggressive cancer. Stage 1 HER2+ is early, but you also need to also consider the level of HER2+ positivity, if there is hormone positivity, and the grade (1,2 or 3) of cancer cells. Do you have a KI-67 score? That may help inform your next steps. Treatment is always a personal choice. For myself I never questioned going forward with cancer chemo targeted therapy treatment, as the attributes of the tumor I had suggested a poorer prognosis if I did nothing.

I was diagnosed with stage 1, HER2+ (positivity 3), hormone negative, grade 3 breast cancer post mastectomy in January 2023. The surgery was for multi-focal DCIS in my left breast and localized DCIS in my right breast (those were diagnosed in October 2022, so no chemo prior to surgery). Once the HER2+ tumor stage 1 was found I made the choice to be treated with Kadcyla (TDM1), a chemo targeted drug, emtasine bound with herceptin. I was supposed to have 17 rounds, but had to stop at 13 due to increased liver enzymes not in scope of what's considered reasonable. I continued to work fulltime through treatment with the exception of an infusion day every 3 weeks. I did struggle some with fatigue. It's now been over a year and half since treatment ended and I am doing very well.

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@melaniesherman im glad you are doing well-what do you do for work? i work as a nurse and want to try and continue

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bradpitt12 | @bradpitt12 | Jan 8 11:42pm
In reply to @raebaby "I am 83. I had Her2+ at 79. I had a lumpectomy, chemo with herceptin and..." + (show)
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I am 83. I had Her2+ at 79. I had a lumpectomy, chemo with herceptin and 5 weeks of radiation every day. I refused hormone inhibetors. The oncologist finds no signs of cancer in my blood work.

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@raebaby why did you refuse the hormone inhibitors? glad you are doing ok

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raebaby | @raebaby | Jan 9 1:20pm

Because i had a horrible menopause with no estrogen . I was very emotional . Feelng like that is not being alive.

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