Auvelity and ketamine infusions

Posted by groveben4040 @groveben4040, Jun 3, 2025

I’m a long time sufferer of MDD. I started doing ketamine infusions in 2024. I had very low expectations due to my many past med failures. I responded well and felt I was atleast in a partial remission. The cost of the infusions made me space out booster treatments too far in between. Sure enough I’m back to being depressed. Furthermore the ketamine treatments seem to be less effective when I resumed getting them. Now I’ve just begun Auvelity and would be very interested in hearing of others experiences with it. Also I’d be curious if any other people here have done ketamine infusions that was helpful initially, but has become less effective. Thank you

Interested in more discussions like this? Go to the Depression & Anxiety Support Group.

Profile picture for paulchristison @paulchristison

I've been battling with depression my whole life i've tried everything I recently went on an Auvelity equivalent of 100mg of Bupropion and 7.5 ml of dextromethorphan cough medicine. It actually seems to work It's the only thing that I have tried the last 40 years that has actually done any good.

Jump to this post

@paulchristison Extremely happy for you♥️

REPLY

Hi. I have been on IV ketamine since February, 2024. It saved my life

REPLY
Profile picture for fitchick @fitchick

@pbradley1954
Hi no I haven't because I have MS but I get IV ketamine therapy

Jump to this post

What's it do?

REPLY

For chronic pain. Ketamine IV

REPLY

Antidepressants can indeed be quite expensive. I've run into this personally.

At the same time, just wanted to gently point out the potential dangers and risks of "making your own," as bupropion and dextromethorphan (Auvelity) is different then taking a prescription of bupropion and cough medication, according to a colleague who works in Psychiatry & Psychology. Please consider consulting with your doctor about alternatives to concocting medications. Manufacterer savings programs have also been useful to me over time for more expensive medications, and I see that there is one available from the maker of this pharmaceutical.

You might also be interested in this Mayo Clinic Press publication about depression treatment:

- Depression’s new directions - Mayo Clinic Press https://mcpress.mayoclinic.org/major-depressive-disorder/depressions-new-directions/

REPLY
Profile picture for Lisa Lucier, Moderator @lisalucier

Antidepressants can indeed be quite expensive. I've run into this personally.

At the same time, just wanted to gently point out the potential dangers and risks of "making your own," as bupropion and dextromethorphan (Auvelity) is different then taking a prescription of bupropion and cough medication, according to a colleague who works in Psychiatry & Psychology. Please consider consulting with your doctor about alternatives to concocting medications. Manufacterer savings programs have also been useful to me over time for more expensive medications, and I see that there is one available from the maker of this pharmaceutical.

You might also be interested in this Mayo Clinic Press publication about depression treatment:

- Depression’s new directions - Mayo Clinic Press https://mcpress.mayoclinic.org/major-depressive-disorder/depressions-new-directions/

Jump to this post

@lisalucier my personal experience trying both brand-name Auvelity as well as “homemade” (generic bupropion and generic dex) is that they are NOT the same, AT ALL. I know it works great for some and cost is certainly an issue. However I was personally blown away at the difference; I would guess there is a time-release mechanism at play with the combo that made the difference for me.
Personally I found Auvelity very dangerous for me but I am glad when I hear about any treatments having a positive effect for others. It’s worth a conversation with your prescribing physician for sure.

REPLY
Please sign in or register to post a reply.