Histamine Intolorance

Posted by jjentges @jjentges, May 22, 2025

Has anyone who has developed histamine intolerance from long COVID used any of the DAO or Histamine Blockers? Also is anyone taking Probiotics? Would appreciate any info on worked for you.

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tiredandthristy | @tiredandthristy | Jun 2, 2025

In reply to @jimthescientist "COVID Journey (Posted on the 18 the but it relates to your post. COVID causes a..." + (show)

@jimthescientist

COVID Journey (Posted on the 18 the but it relates to your post.

COVID causes a persistent whole body inflammatory response which can be largely corrected by adopting and EXTREME diet and nutrition plan. Most people will not be willing to sacrifice “the food that I love” for a chance to return to a healthier pre-COVID life. For me, now that I feel like I once did, it was worth it and continues to be worth it.

I’m 70 now. COVID March 2020. Mild case resulting in brain fog, neuropathy in my legs that became disabling by March 2021, Raynaud’s Syndrome (Diagnosed March 2021), inability to walk on my treadmill, 12 skin infections from 2020-2024 from simple cat scratches or mosquito bites, progressing to infection and cellulitis, requiring 10-14 days antibiotics, hives and itching on my head and upper back and inflamed hot hands and feet and temperature regulation issues.

In March 2021 I went gluten free and stopped eating dairy, red meat, deli meat and pizza and added 2 meals a day of blueberries, rolled organic oats, and Vega protein + greens and also added 1500 mg l-proline which is the active AA in collagen supplements. Within 3 months, the brain fog, neuropathy and leg pain were gone, and I was back walking on the treadmill, however the skin infections, hives and itching remained. In October 2024, I added one ounce of pumpkin seeds a day (ground to a powder in a spice grinder and added to pasta), and that fixed my skin inflammatory/infection issues.

The hives and itching continued and were corrected by realizing that this “Evil Thing” causes food allergies to ANY food or spice that releases histamine. I had to eliminate, yogurt, mayo (contains vinegar), garlic, rosemary, dill, tomatoes, and salsa. I know the food thing to be real because I have tried to add these things back in one at a time and if I do I get the itching and scalp hives within 3 hours after eating which persist 2-3 days. I have tried several probiotics but all caused a histamine release so I don't use them.

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red meat is fine as long as it's pasture raised

jjschla | @jjschla | May 26 5:17am

I believe I have Histamine Intolerance which started right after having Covid. I am just going to try DAO supplements and Probiotics. I am very interested in if anyone else has found anything that works. My intolerance shows up as headaches. If I stick to low Histamine foods, I don't get headaches. I have also limited Gluten in my diet, which also seems to make headaches more frequent.

jjschla | @jjschla | 5 days ago

In reply to @jjschla "I believe I have Histamine Intolerance which started right after having Covid. I am just going..." + (show)

I have the exact same experience. I am just trying Probiotics and DAO supplements. Too early to tell if they will help. I also have a new symptom, low platelets. I used to donate platelets up until last year, now I have about 50%-70% of the lower limit of recommended platelets level
@jjschla

greg1234 | @greg1234 | 4 days ago

Yes, and here a couple of things that helped me.
--H2 antihistamines, the most common is famotidine, aka Pepcid. Here's the clinical trial that kicked it off: https://www.cshl.edu/famotidine-clinical-trial-shows-covid-19-symptom-reduction/. Note that Claritin and other seasonal anithistamines are H1, and probably will not help. I know you might balk, thinking famotidine is an anti-acid, but it works as an H2 antihistamine!
--Probiotics, try a high quality one like Garden of Life. also, PREbiotics like acacia fiber, huge benefit for me. I encourage you to check funtional medicine doctor Leo Galland MD's piece on Long Covid for other specific probiotics, diet and supplements. A healthy biome can benefit most long covid symptoms. He was the first doctor to write articulately about covid and long covid, and saved my life. Here's the link: https://drgalland.com/long-covid you can download the paper at the bottom of the page. You can search in it for specific symptoms, but please read the beginning to get a real understand of covid and long covid.
--Note that probiotics and prebiotics should be taken on an EMPTY STOMACH BEFORE A MEAL!!!!!!!!!!!!!!! Otherwise stomach acid in digestion will kill the good bugs!
Be well!!!!!!!!!!!!!!!!!

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