What helps prevent recurrence of endometrial cancer?

@pangasinan143, welcome. I pulled your comment into a discussion of its own. It's a good question. I see from your profile that you were diagnosed with endometrial cancer just a few months ago (Jan 2026) and recently finished readiation and are now receiving chemo treatments.

Of course, you want to do everything you can to prevent or reduce your risk of it coming back. While there are no full proof ways to 100% prevent recurrence, living a healthy life style can help reduce risk. Things like maintain a healthy weight, exercise regularly, and eat a nutritious diet.

Have you and your oncologist talked about specific risk factors that you need to consider?

It depends on the diagnosis, and stage of the cancer, to begin with. Other considerations which weren't paid to me was that carboplatin/paclitaxel combo therapy wasn't going to work as my cancer was platinum resistant, as cancer was not resolved, and came back worse within a couple of months.
I was switched to Enhertu (administered in a clinical study--which is ongoing), after other tests including biopsies of tissues were taken.
I've been on this trial for 1 year and 5 months, with infusions every 3 weeks. It's tough and there is no end date, but it worked! I have high grade 3C1 serous cell endometrial cancer HR2+.
So to recap tell us type and stage your cancer is, and I'm sure other participants here can give you answers.
Good luck and try not stress out.

I try to create an environment in my body where cancer is less likely to grow by taking supplements. I try to avoid "snake oil" treatments and know nothing will be a total cure, but I posted and combed through sites like this and identified supplements that PEOPLE WITH NO RECURRENCES take. No one knows if the supplements truly were the reason for their success, but I generated a very extensive list then reduced it to a few based on my own research and people's stated experiences.

That’s a million dollar question unfortunately all you can do is be proactive and make sure you get all your check ups. I had uterus cancer 2009 recurrence in 2016 after being told I was cancer free and there was only a 1% chance of recurrence. It never occurred to me that I would be in the 1%. I had my hysterectomy in Texas and we moved back to California. I went to 3 gynecologists but not one of them would use a speculum because of my low risk, fourth doctor I insisted and she said ok but I doubt you will have anything, WRONG.. recurrence. I had to have radiation and brachytherapy. If you learn anything from this don’t rely on your doctors they don’t always know what the right thing is for you? Just be PROACTIVE it will save your life. My new gynecologist oncologist is very through but at my last visit she mentioned a doctor that would be joining her group I said he was one of the doctors who wouldn’t use a speculum…..what could she say?

@colleenyoung And, I would add to those good suggestions—find all the love and joy you can, as that helps any health situation !

@pangasinan143 Welcome to Mayo Clinic Connect and to our Gynecological Cancers support group. I was diagnosed with endometriod adenocarcinoma, FIGO 1, Stage 1 a in 2019. I had a radical hysterectomy including removal of ovaries, fallopian tubes, and cervix. I had a recurrence in 2021 that was found by my nurse practitioner during one of my cancer surveillance visits (a very tiny polyp-like growth on my vaginal cuff). For that, I had 25 sessions of external radiation therapy and 2 sessions of brachytherapy. I’ve been NED (No evidence of disease) since then.

There are many different factors in cancer prevention and one of the best is to make sure you return to your provider for all of your required cancer surveillance (cancer follow-up) appointments.

I began working with an Integrative Medicine physician after my recurrence. She has helped me to manage my diet, supplements, mood, and activity levels. I really stepped up my game in these areas. You might like to read the posts by @denisestlouie. She has started a number of Discussions here in our support group that provide an account of her own story during active treatment of her cancer all the up to recently. She details the dietary changes she made working with her doctors.

My Integrative Medicine physician tells me that is not a lot of evidence for how to prevent recurrence of endometrial cancer. She tends to go with the evidence for breast cancer and she tends to go with these. These include adding turmeric to your diet (I do this through adding turmeric to food I prepare), mushrooms (I add this as a powder to my coffee), to name just two recommendations she made to me. She also referred me to a nutritionist whose speciality was cancer and I found that to be very helpful.

How are you feeling? Are you in active treatment with radiation therapy, chemotherapy or immunotherapy?

Hello Helen, I am on ongoing therapy at the moment. Had 27 rounds of external radiation, and 4 chemo cycles and 2 more chemo to go.

@colleenyoung

It has been a year since my diagnosis and the chemo and radiation treatments behind me.
I'd say be your strongest advocate, ask questions of your cancer team, and do what they tell you to do. Seek out integrative treatments but know that Medicare doesn't cover most of them like naturopathic medicine or acupuncture unless you have medicare advantage. And most importantly stay positive and take good care of yourself.

@pangasinan143 You are almost done with this therapy. That's good news, right? How are you feeling at this point in time? Have you thought about what you might like to do to for prevention of a recurrence?

@cookercooker I too have same cancer. Having 1st treatment of doxorubicin on the 25th. It will be my 4th type of chemo. The Herceptin nor the Enhertu worked for me. I say it didn't because my CA125 always went up. I only had 4 treatments of Enhertu and read that it can take that or more to see results with it. Lab work was done before the 4th treatment of it and I'll have labs the 19th but not a CA125. I'm stage 3C, diagnosed 2/2025. Had hysterectomy in Aug 20th, 2025. Couldn't remove any lymph nodes because they were tangled in vascular system. My numbers however did go from 1641 to 80 on the carboplatin and paclitaxal in 4 months. Since surgery they have continued to climb. Puzzling.