Have AFib controlled w/drugs & taken a GLP1 drug to lose weight?

Posted by cmiller57 @cmiller57, May 29 1:27am

I am wondering if any AFib patients like me, who are controlling their AFib with drugs have also taken a GLP1 drug to lose weight? I read a study done in 2025 that showed that GLP1 lowered the amount of AFib events by about 13-18% in obese AFib patients. hrsonline org /news /glp1 -study-reduces-afib-events

I talked to my doctor about doing it, but she thought it might not be a good idea and I didn't talk to my cardio yet. In the study a few adverse reactions did happen but overall, the majority had good outcomes or no difference. They didn't do it to judge weight loss but just took low doses for the AFib question. I am going to talk to my cardiologist though asap because I want to use it for weight loss and the other could be a plus. If anyone has done this, please let me know how it went.
Thanks

Interested in more discussions like this? Go to the Bariatric Surgery & Weight Loss Support Group.

Laurie, Volunteer Mentor | @roch | May 29 6:46am

@cmiller57

Welcome to Connect. I have no direct experience with GLP-1 or AIF, but I was interested in your question. I read the article you referenced, and there are other recently published articles. For hose interested, here is link referenced in discussion: https://www.hrsonline.org/news/glp1-medications-lower-afib-risk/

I also found this Univ of Virginia that gives a good explanation of a study on the same subject:
https://www.uvahealth.com/healthy-balance/glp-1-may-also-help-heart
It also concludes with the following statement: "More research is still needed, especially regarding how different GLP-1 medications, doses, and treatment durations affect weight loss, inflammation, glucose control, Afib risk, and long-term cardiovascular health."

You might want to review this discussion in the Heart Rhythm group. Some members had problems with the combination. Another member mentioned the study you mentioned.
https://connect.mayoclinic.org/discussion/glp-1-drugs-causing-arrythmias/
But everyone is an individual, and you are smart to discuss with your cardiologist before starting any new medication.

merrychristmas | @merrychristmas | May 29 8:50am

I am taking Zepbound for sleep apnea . I have afib too . I noticed my Afib events are going down . I used to get them daily and now I get 2-3 events a month!! Yay.

cookiejoviolero13 | @cookiejoviolero13 | 3 days ago

I am on tikosyn for AFIB and Mounjaro for prediabetes and weightloss. I've been on Mounjaro for 6 months and hadn't been aware of the glp-1 connection until I read the above. Yes, I am having fewer issues with feeling palpitations!

Lisa Lucier, Moderator | @lisalucier | 3 days ago

In reply to @cookiejoviolero13 "I am on tikosyn for AFIB and Mounjaro for prediabetes and weightloss. I've been on Mounjaro..." + (show)

@cookiejoviolero13 - that sounds like a great benefit to the GLP-1 that you are having fewer issues with palpitations. Definitely share that with your cardiologist and whichever provider prescribed the tirzepatide (Mounjaro). I would expect they'd be interested.

Is the tirzepatide (Mounjaro) also helping your prediabetes and your weight?

cookiejoviolero13 | @cookiejoviolero13 | 2 days ago

Yes! Since Feb 2026 I have gone from 208 to 188. Slow but steady.

crystalblue | @crystalblue | 12 hours ago

In reply to @merrychristmas "I am taking Zepbound for sleep apnea . I have afib too . I noticed my..." + (show)

@merrychristmas I am taking Zepbound and also have sleep apnea and A-Fib. How does it affect sleep apnea, other than weight loss?

merrychristmas | @merrychristmas | 7 hours ago

In reply to @crystalblue "@merrychristmas I am taking Zepbound and also have sleep apnea and A-Fib. How does it affect..." + (show)

@crystalblue I can’t say . I pull off my mask ( nasal pillows) all the time . It records I get under 3 hours of sleep. But my Afib is 90% better I don’t know if the weight reduction or not. I lost 65# since last September. I am 5# till I am the healthy wt on the BMI chart !!

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