What’s my chance of lung cancer?

Posted by windywinland79 @windywinland79, May 25 11:03pm

Hello! I’m a 46F recently on 4/23/2026 I went to my regular dr. I’m losing weight pretty fast (about 65 pounds in like 4 months) and so I wanted to see about getting some ensure prescribed to me to help me gain weight. Well, I have been a smoker since I was 12 years old, so my doctor wanted me to start by doing a just normal regular x-ray of my lungs because they have never been checked well once they did the x-ray they found a nodule on my left upper lobe and I was then scheduled the very next day to get a CT scan. Well, it confirmed I guess the size of it. This demonstrated a 1.3 x 2 x 1.4 cm spiculated nodule in the left upper lobe. I then had to do a PET scan on the 20th of this month and that area lit up pretty bright so tomorrow morning well I guess today Tuesday, May 26. I have to have a biopsy done. My question is has anybody ever had this happen and how likely is it that it very well is cancer they said the area is not smooth. It is spiky but it is situated in one area. Ohh they also said I have SEVERE emphysema

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Left upper lobe of lung, transbronchial biopsy:
Non-small cell carcinoma.
Comment: Immunohistochemistry is performed and the tumor is positive for TTF-, Napsin, CK7 and focal CD56 and negative for
CK5/6 p40 and CK20 the tumor cells have an oncocytic cytomorphology. An adenocarcinoma is favored. All matched controls
are appropriate.
For routine quality assurance, the case is reviewed as an intradepartmental consult with concurrence. I JUST COPIED THIS FROM MY FINAL REPORT

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Profile picture for windywinland79 @windywinland79

@mamajite but yes, when I had my biopsy yesterday, they did do the bio markers. I wish I knew a way of being able to post pictures because I have the test results and everything else. I don’t really understand them. I don’t get to see my doctor clear until next Wednesday on the June 3

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@windywinland79 glad you're feeling ok after the biopsy. sorry to hear you've joined our club, but it's great you have a good team and they have a treatment plan already. if you see any mutations listed on your test results you can share them - usually a combination of 5 letters and numbers like L858R. is your lung nodule the only place they found cancer?

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Profile picture for medtech4 @medtech4

Your history does sound like lung cancer. The lung biopsy is done under general anesthesia. You may cough after that for several minutes. That's normal. They should remove enough and in different areas for the biopsy. They should take enough that they can test for mutations. I only smoked for about 16 years, since age 15 to age 31. I'm 68 now. I was diagnosed in the fall of 2025. I had a CT of the abdomen and an incidental finding saw the nodule. I saw a pulmonogist about a month later and had a negative biopsy a month after that. I went for a follow up biopsy in December 2025 and that was positive for non small cell lung cancer (adenocarcinoma). I started chemo and targeted treatments in January 2026 and I'm doing pretty well, considering. Good luck to you. I am on the lung cancer support group here. The people there are very nice and very helpful, especially with the questions and concerns about treatment. Sometimes, doctors don't know as much as the patients about side effects (although they vary from person to person) and how things may occur medically.

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@medtech4 Left upper lobe of lung, transbronchial biopsy:
Non-small cell carcinoma.
Comment: Immunohistochemistry is performed and the tumor is positive for TTF-, Napsin, CK7 and focal CD56 and negative for
CK5/6 p40 and CK20 the tumor cells have an oncocytic cytomorphology. An adenocarcinoma is favored. All matched controls
are appropriate.
For routine quality assurance, the case is reviewed as an intradepartmental consult with concurrence.
I JUST COPIED AND PASTED THIS FROM MY FINAL REPORT FROM MY BIOPSY

REPLY
Profile picture for mamajite @mamajite

@windywinland79 glad you're feeling ok after the biopsy. sorry to hear you've joined our club, but it's great you have a good team and they have a treatment plan already. if you see any mutations listed on your test results you can share them - usually a combination of 5 letters and numbers like L858R. is your lung nodule the only place they found cancer?

Jump to this post

@mamajite Left upper lobe of lung, transbronchial biopsy:
Non-small cell carcinoma.
Comment: Immunohistochemistry is performed and the tumor is positive for TTF-, Napsin, CK7 and focal CD56 and negative for
CK5/6 p40 and CK20 the tumor cells have an oncocytic cytomorphology. An adenocarcinoma is favored. All matched controls
are appropriate.
For routine quality assurance, the case is reviewed as an intradepartmental consult with concurrence.
THIS IS MY FINAL REPORT FROM MY BIOPSY IM NOT GOOD WITH ALL THOSE BIG WORDS AND STUFF

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I’m going to copy and paste my final report from my biopsy I had yesterday on my left lung I need help understanding what it means and I don’t see my dr until June 3rd.Left upper lobe of lung, transbronchial biopsy:Non-small cell carcinoma.Comment: Immunohistochemistry is performed and the tumor is positive for TTF-, Napsin, CK7 and focal CD56 and negative forCK5/6 p40 and CK20 the tumor cells have an oncocytic cytomorphology. An adenocarcinoma is favored. All matched controlsare appropriate.For routine quality assurance, the case is reviewed as an intradepartmental consult with concurrence.

REPLY
Profile picture for windywinland79 @windywinland79

Left upper lobe of lung, transbronchial biopsy:
Non-small cell carcinoma.
Comment: Immunohistochemistry is performed and the tumor is positive for TTF-, Napsin, CK7 and focal CD56 and negative for
CK5/6 p40 and CK20 the tumor cells have an oncocytic cytomorphology. An adenocarcinoma is favored. All matched controls
are appropriate.
For routine quality assurance, the case is reviewed as an intradepartmental consult with concurrence. I JUST COPIED THIS FROM MY FINAL REPORT

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@windywinland79 those tests are used to figure out which kind of cancer you have. it means they think it's most likely lung adenocarcinoma.

this page from the American Cancer Society has a good explainer of the pathology terms/tests:
https://www.cancer.org/cancer/diagnosis-staging/tests/pathology-reports/lung-pathology.html

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Profile picture for mamajite @mamajite

@windywinland79 those tests are used to figure out which kind of cancer you have. it means they think it's most likely lung adenocarcinoma.

this page from the American Cancer Society has a good explainer of the pathology terms/tests:
https://www.cancer.org/cancer/diagnosis-staging/tests/pathology-reports/lung-pathology.html

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@mamajite thanks! I’m going to look into it!

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Profile picture for donnademps @donnademps

Hello @windywinland79, This is a GREAT forum to use and learn from. The process you have gone thus far sounds very similar to mine, here in Canada. The biomarker test I took was the longest wait for me, as my mutation was a rare one. I'm not a medical person, but I have recently been through a lobectomy. It sounds like you are in great care, having been through all these tests. I am so glad I joined this group, I had no support group in my area with folks with cancer could get together and chat about their experiences. When I found this group, there were many people who could answer my questions, especially for the post-op information. I hope to continue to see you here. Good luck with your appointments.

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@donnademps yes! I love it here I just joined yesterday! But I had my biopsy yesterday and I have the results back already! My Dr. even was impressed with how fast they finalized it! But I’m positive for non-small cell cancer 🥹☹️ but my team is on top of it and he said we need to do a few aggressive treatments and then he will go in and take the upper lobe of my left lung out. He is very positive that they can get it out of me!

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Profile picture for windywinland79 @windywinland79

@medtech4 Left upper lobe of lung, transbronchial biopsy:
Non-small cell carcinoma.
Comment: Immunohistochemistry is performed and the tumor is positive for TTF-, Napsin, CK7 and focal CD56 and negative for
CK5/6 p40 and CK20 the tumor cells have an oncocytic cytomorphology. An adenocarcinoma is favored. All matched controls
are appropriate.
For routine quality assurance, the case is reviewed as an intradepartmental consult with concurrence.
I JUST COPIED AND PASTED THIS FROM MY FINAL REPORT FROM MY BIOPSY

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@windywinland79 The oncologist should have a plan in place for this type of cancer and the the tumor types you have genes for. My oncologist gave me copies of a recommended treatment plan with my mutation, EGFR and the drugs used to treat that specifically. It was actually a scientific study, but not too hard to understand. I worked in the medical field and I never encountered reports like this.

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Profile picture for windywinland79 @windywinland79

I’m going to copy and paste my final report from my biopsy I had yesterday on my left lung I need help understanding what it means and I don’t see my dr until June 3rd.Left upper lobe of lung, transbronchial biopsy:Non-small cell carcinoma.Comment: Immunohistochemistry is performed and the tumor is positive for TTF-, Napsin, CK7 and focal CD56 and negative forCK5/6 p40 and CK20 the tumor cells have an oncocytic cytomorphology. An adenocarcinoma is favored. All matched controlsare appropriate.For routine quality assurance, the case is reviewed as an intradepartmental consult with concurrence.

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Hi @windywinland79, These pathology reports can be difficult to interpret, so that's best left to the doctors. I'm sorry to hear that the biopsy showed cancer. But now the doctors can move forward with treatment, and from what you've said, they are hopeful that the surgery will be successful. Try to focus on that piece of good news. I'm sure you'll find out more next week at the appointment. Please let us know how the appointment goes.

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