Anyone taking Mirtazapine? Is it working for you? Any side effects?

Posted by cmarts @cmarts, Mar 4, 2025

Has anyone been taking Mirtazapine? Like to know if they have taken themselves off and how did you do it?

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Profile picture for ladydi82 @ladydi82

Hello, I’ve been on mirtazapine since March 2025. I was on 15mg, but as of last night I am on 7.5mg. I want to completely taper off. How long should I stay on 7.5mg by experience before stopping completely? Like I mentioned, I haven’t been on it long. Thanks!

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I wish I could get off effexor

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Profile picture for tisme @tisme

I wish I could get off effexor

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@tisme - here are a couple of discussions (among many, if you'd like to search for more) on Mayo Clinic Connect you may want to check out on getting off of venlafaxine (Effexor):

- Effexor tapering question https://connect.mayoclinic.org/discussion/effexor-tapering-question/

- As promised, my successful tapering off Effexor (Venlafaxine) https://connect.mayoclinic.org/discussion/as-promised-my-successful-tapering-off-effexor-venlafaxine/

- What to bridge when tapering off effexor https://connect.mayoclinic.org/discussion/what-to-bridge-when-tapering-off-effexor/

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Profile picture for ladydi82 @ladydi82

Hello, I’ve been on mirtazapine since March 2025. I was on 15mg, but as of last night I am on 7.5mg. I want to completely taper off. How long should I stay on 7.5mg by experience before stopping completely? Like I mentioned, I haven’t been on it long. Thanks!

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is Effexor available in tablet form over there??? It isn't in Australia we are stuck with capsules.

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Profile picture for ladydi82 @ladydi82

Hello, I’ve been on mirtazapine since March 2025. I was on 15mg, but as of last night I am on 7.5mg. I want to completely taper off. How long should I stay on 7.5mg by experience before stopping completely? Like I mentioned, I haven’t been on it long. Thanks!

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Are you on 7.5. Now

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Profile picture for frouke @frouke

I was on this medication for a couple of months and it was a very unpleasant experience, the only thing I liked was the appetite it gave me but that was it, getting off them was easy, I took one every other day for two weeks and then stopped and never had any issues doing so, you’ve been on them very briefly so you shouldn’t have any problems.

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@frouke what didn’t you like about it?

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Profile picture for dave14 @dave14

@cmarts Good day. I take 45 mg of Mirtazapine at night and usually have a headache the next day around 0500 pm or so which I take 2 extra strength Tylenol to combat this with. It’s not a severe headache, about a five or 6 on the pain meter but it will linger if I do not take the the Tylenol 500 mg X 2. Occasionally I have to take 4 over the course of the day if the headaches start earlier in the day. Just wondering if anyone else has these adverse affects on the drug. Should I decrease the dosage to 30? I’m a little reluctant to do so as I am still having anxiety with 45 and don’t know if lowering the dosage might help or make matters worse.

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@dave14 That seems like a lot. I take 15mg for sleep and have no side effects. I find it helps me to get a good nights rest.

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Profile picture for Lisa Lucier, Moderator @lisalucier

@visionsofelvis - I don't believe I've yet met you on Mayo Clinic Connect, so welcome. I wanted you to know I moved your message here where others were discussing a similar theme about wanting to be off of mitrazapine:

- Tapering off mirtazapine https://connect.mayoclinic.org/discussion/tapering-off-mirtazapine/

Does your prescribing physician have a tapering schedule you might follow to safely taper off this medication with a minimum of side effects? Are you going to be moving to another medication instead of this one?

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@lisalucier I live in Las Vegas and health groups are terrible here. I have an appointment week from today with this psychiatrist and hopefully he’ll be able to taper me off slow so I don’t have bad anxiety. Began 15 mg on Jan 8 then April 1st began 7.5. It’s been a rollercoaster. You’re lucky you were on it for short time. Any advice?

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Profile picture for Lisa Lucier, Moderator @lisalucier

@visionsofelvis - I don't believe I've yet met you on Mayo Clinic Connect, so welcome. I wanted you to know I moved your message here where others were discussing a similar theme about wanting to be off of mitrazapine:

- Tapering off mirtazapine https://connect.mayoclinic.org/discussion/tapering-off-mirtazapine/

Does your prescribing physician have a tapering schedule you might follow to safely taper off this medication with a minimum of side effects? Are you going to be moving to another medication instead of this one?

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@lisalucier hi Lisa just had telemed call with my physician assistant and she advised me to just stop the 7.5 mg of mitrazapine I said and how will I get to sleep and I said I was in stabilizing period which I’m getting lot of anxiety . What would you do? Also I’ve been on 7.5 for 6 weeks

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Doc prescribed 3.25mg, yes, 1/2 of a 7.5mg teeny tablet.
It makes me so groggy in the morning I’m quitting it.
I take diltiazem 120 extra for heart and so there really is no good sleep aid I can take. (Cardiologist recommended 5mg of trazodone?)
I suffer from “epic dreaming”?? So I never feel rested.
I’m doing my own research, can’t live like this.

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Je prends 15 mg de mirtazapine aux deux jours. L'effet le plus désagréable pour moi est la constipation que cause le médoc. Toutefois, il participe à un bon sommeil.

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