My Autoimmune Journey: From 1:5120 to 1:320 ANA
Hey everyone,
I wanted to share my autoimmune journey and the steps I’ve taken to improve my ANA levels over the past year. For those who don’t know, a positive ANA result indicates an autoimmune condition, but it doesn’t always point to a specific disease. My journey has been full of trial and error, but I’ve managed to bring my ANA titer down from 1:5120 to 1:320, and I’m determined to lower it even further to under 1:80.
What I Did to Improve
Dietary Changes:
The best results came when I completely cut out gluten, dairy, and sugar from my diet. This step alone had the most significant impact on my inflammation and symptoms.
I focused on phytonutrient-rich foods like salads, green veggies, berries, and pasteurized sugar-free juices, especially berry juices. These foods became staples in my routine.
I incorporated 3-4 tablespoons of extra virgin olive oil (EVOO) daily, vegan protein shakes, and clean meals like chicken and rice.
Fiber intake was a priority, but I didn’t always hit my target of 40-50 grams per day. On most days, I managed 10-30 grams, using basil seeds, chia seeds, and psyllium husk to boost my intake.
From time to time, I also added dark chocolate or cacao powder to my shakes for its antioxidant benefits.
Additionally, I included collagen in my diet occasionally, either through bone broth or collagen supplements, which helped support my gut health and overall recovery.
Supplement Protocol:
I took a number of supplements, but to keep this section brief, I’ll only be mentioning the most important ones that I think were the most helpful. These included:
Vitamin D3
Omega-3 fish oil
Probiotics
Turmeric (curcumin)
Magnesium
Zinc
Vitamin C
Lifestyle Adjustments:
Sleep: Sleep was a key focus for me, and I took several steps to improve it.
I used melatonin (1mg, 2mg, or 3mg, never exceeding 3mg) to help regulate my sleep.
I tracked my deep sleep and REM sleep using a smartwatch, which gave me insights into my sleep quality.
To further improve my sleep environment, I used an eye cover to block out light.
Exercise: While I didn’t follow a strict five-day plan, I aimed to go to the gym consistently at least three times per week. This helped boost my energy and overall health.
No Medications:
One of the most important things I want to highlight is that I did this completely naturally, without using any steroids or medications. I was off all medications throughout this year, relying entirely on diet, supplements, and lifestyle changes to improve my health.
The Resources That Helped Me
Throughout this journey, I’ve learned so much from amazing experts and books that were incredibly helpful in shaping my protocol. These resources not only informed my approach but also provided hope and actionable steps for healing:
Amy Myers, MD, author of The Autoimmune Solution. Her book is a must-read for anyone dealing with autoimmune conditions and seeking a structured, comprehensive guide to healing.
Mark Hyman, MD, his insights into root cause approaches to health are transformative. He has also appeared on numerous podcasts, which are a great way to learn from his expertise and gain valuable health insights.
Dr. Chanu Dasari, MD, whose expertise in autoimmune healing and dietary strategies, especially through The Phytodiet Primer, has been invaluable.
Books like Beat Autoimmune by Palmer Kippola, The Autoimmune Fix by Tom O’Brien, and The Phytodiet Primer by Chanu Dasari provided practical strategies and tools for managing and reversing autoimmunity. These books are highly recommended for their actionable advice and deep insights into the causes and solutions for autoimmune conditions.
I highly encourage anyone on a similar journey to explore these experts and their work—their knowledge can make a huge difference in your healing process.
The Results So Far
ANA levels: From 1:5120 to 1:320 in one year.
Symptoms: My vasculitis and joint pain are 90% better. Flare-ups are minimal and mostly linked to specific triggers I can now identify.
Energy: I feel much more balanced, although I’m still fine-tuning my routine for optimal recovery.
What I’m Doing Next
Gut Healing:
Gradually reintroducing probiotics with diverse strains using kefir and Greek yogurt.
Rotating supplements and prebiotics to enhance gut flora diversity.
Long-Term Goals:
Lower my ANA to under 1:80 and maintain it through a sustainable lifestyle.
Continue to prioritise sleep, stress reduction, and regular movement.
Why I’m Sharing This
I’m sharing my story in the hope that it might help someone who is on a similar journey, or that someone might share insights to help me improve on something I may have missed.
I’ll also be updating this post as my ANA levels change (and hopefully lower).
If you have any questions about my journey, supplements, or routines, please feel free to ask—I’d love to help in any way I can.
Interested in more discussions like this? Go to the Autoimmune Diseases Support Group.
Connect

Did you have any stomach issues taking tubers and magnesium? Thanks
Going over last blood draw my Ana very high there’s also tittered and speckled. Does these have anything to do with icap?
Yes. https://pmc.ncbi.nlm.nih.gov/articles/PMC8971673/.
Thank you very much a lot of reading material. Very informative
Hi your post is from a year ago - I hope you get this and can give me some advice. I started having joint and muscle pain maybe over 7 years ago then my doctor ordered an ANA test and came back with 1:80. Went to see a Rheumatologist but he ruled out RA. My last ANA result (a month ago) is 1:320 homogeneous. What does it mean? Do I have autoimmune?? I do feel tired all the time and my muscle and joint pain seem to get worse. I am changing my diet as well as walking 3 miles each morning. Glad I found your post and will try some of the things you’re doing and hopefully will improve my ANA numbers. Thank you and any other recommendations/advice would be greatly appreciated.
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1 ReactionI know that it has been a year and you may not even still be checking the comments but I just wanted to say it made me glad to find another person who has cured their autoimmune disease with diet. I haven't had a flare or joint damage/pain for 7 years now since I started eating mainly anti-inflammatory foods. I did have to endure a little joint damage at first while waiting for the diet to start working, but since then I have been in full remission. Continued luck to you and your healthy diet! Best, LL
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7 Reactions@jkjoshua
High ANA Titer is usually associated with autoimmune disease. Your numbers are still low, and this may be an early sign. I was diagnosed with scleroderma 3.5 years ago with ANA Titer 1:2560. At that time, I had fatigue, joint stiffness, and started developing skin thickening over hands first, and then multiple areas of the body. I have tried multiple medications with limited success. Although, for some conditions, medications still may be needed. Anti-inflammatory diet seems like a good option to stay healthier.
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2 ReactionsThank you for sharing your journey. I am very grateful, because it helped me. Your post inspired me and read two of the books you recommended.
My labs were high IgG and a liver antibody marker, plus a dry cough and “mechanic’s hands.”
Magically high-fiber, low-sugar, low-gluten improved cough and hands by 90%, though IgG Is still too high. 5000 instead of 1700.
Did you have anything measured besides ANA?
Has anyone else had high IgG numbers?
Blessings
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2 ReactionsHi @lilytexas — an IgG level of 5000 mg/dL (50 g/L) is markedly elevated (normal is usually below ~1600–1700 mg/dL). When this is combined with a very high ANA result, it can point toward an overactive immune system, often related to chronic inflammation, infection, or, less commonly, a plasma cell disorder.
It would be worth discussing these findings with your doctor. They may consider referring you to a specialist—such as a rheumatologist or hematologist for further evaluation, including checking for conditions like lupus or other autoimmune disorders.
Hello, I have read your post and the comments a couple of times. I started with your recommendation of the Dr. Meyers book. I began the AIP diet two weeks ago. My ANA has doubled within the year to 1:1280 homogeneous. The doctors, including the rheumatologist, have run every marker, and they are all normal, which is good news. They gave me a generic disease name that isn't really a disease, which I can not recall. My doctor gave me Methotrexate, which I stopped after two weeks due to bleeding, and then another hydro.... something or other immunomodulator, which I am not taking. I just don't think medicine is the way to go since they do not know what I have. I am praying I can do what you did and reverse the inflammation. I have symptoms of swollen pinkie knuckle, circulation issues, some skin issues that come and go, and joint pain now and then. My question is, do you recommend any calorie restriction? More plant-based? Any other recommendations to be successful? I am determined. I am asking my doctor if HRT could be making this worse? Just not myself. Been "healthy" my entire life so finding this difficult, but not impossible. Any feed back from anyone is welcome.