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Anyone else on Daraxonrasib (RMC-6236)?

Posted by howleegirl @howleegirl, May 8 5:59am

Waiting for the approval for my husband to start daraxonrasib. (the new and exciting drug just fast tracked by the FDA) Doc says he's a great candidate for this drug. Anyone else on this? I know about the awful rash you get from seeing the senator on TV. Doc has also styopped all treatment since April 11th. THAT kinda scares me?

Interested in more discussions like this? Go to the Pancreatic Cancer Support Group.

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gracect | @gracect | Aug 1 7:32am
In reply to @stageivsurvivor "Patients going through one of these sites for daraxonrasib are experiencing varying approval times between 48..." + (show)
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Patients going through one of these sites for daraxonrasib are experiencing varying approval times between 48 hours and 4 weeks.
https://clinicaltrials.gov/study/NCT07573215

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@stageivsurvivor so very helpful for so many.

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mayrox | @mayrox | 5 days ago
In reply to @mcharlesfrancis "Daraxonrasib is one of the most exciting new developments in pancreatic cancer, so I can understand..." + (show)
Profile picture for mcharlesfrancis @mcharlesfrancis

Daraxonrasib is one of the most exciting new developments in pancreatic cancer, so I can understand why your oncologist is optimistic. If your husband is a good candidate based on his tumor's molecular profile, I hope it works very well for him.

The treatment break can definitely be unsettling, but sometimes it's intentional. Your oncologist may want him to recover from previous therapy before starting the new medication, or it may simply be part of the clinical or prescribing process while insurance approval is being completed. If you're concerned, don't hesitate to ask why the pause is necessary and whether they expect it to affect his treatment.

As for the rash, many patients on KRAS inhibitors develop skin reactions, but there are effective ways to manage them. Many oncologists start moisturizers early and may prescribe topical steroids or oral antibiotics if a rash develops. It's important to report any skin changes early rather than waiting until they become severe.

If he hasn't already had one, you might also ask whether his team plans to follow circulating tumor DNA (ctDNA) with a blood test such as Guardant360 or Signatera, in addition to CT scans and CA 19-9. These tests aren't appropriate for every patient, but they can sometimes provide additional information about how the cancer is responding.

I hope the approval comes through quickly and that daraxonrasib is everything we hope it will be. Please keep us posted—many of us are watching these new KRAS-targeted therapies with great interest.

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@mcharlesfrancis
Can you give us an update on your actual experience with daraxonrasib? My friend eagerly awaits this medication. Thanks.

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mcharlesfrancis | @mcharlesfrancis | 5 days ago

I have pancreatic cancer myself, but I have never taken daraxonrasib. My initial treatment was the triplet of gemcitabine, Abraxane and cisplatin for 18 weeks—two weeks on and one week off—followed by 33 days of radiation.

That's why I'm particularly interested in hearing firsthand experiences from people who are actually taking daraxonrasib. These new KRAS-targeted drugs are giving a lot of pancreatic cancer patients hope.

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