Rut Roh Rorge - PSA wrong direction

Posted by mjp0512 @mjp0512, Mar 17 10:44am

ADT / ARSI since June 2025
IMRT Oct 2025

PSA:
4/21/25 - 30.11
7/9/25 - 0.55
8/26/25 - 0.19
12/3/25 - 0.23
3/17/26 - 8.80

Methinks there's a problem. 😮😮😮

Results just popped up on the portal. Haven't heard from the Doc yet but I'm guessing another PSMA PET is in my near future. ALP is pretty high too, so liver or bone mets? Not yellow yet so I'm guessing bone. Maybe an ALP Isoenzyme test to determine source of elevation?

In any case, this sucks a little. 😡

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

Profile picture for Jeff Marchi @jeffmarc

@mjp0512
I would really be surprised to hear they would give you radiation to a prostate spot they’ve already Radiated. That’s usually a lifetime radiation dose.

Be interesting to hear what they come up with.

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@jeffmarc - Yes, I'm looking forward to finding out too. Had to shake the tree a little since my GUO's office told me next month is the earliest they could see me. My PSA doubling time is sitting at 2.8 weeks and has been since March. In my opinion, sitting around for months at a time waiting for treatment is not in my best interest, so I called radiation oncology directly. RO will check my scans and call back today with a treatment plan. And...I wanted him to know that he missed and needs to fix it.

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OK then...got the call back from RO. Stat MRI of lower spine ordered to provide for SBRT targeting of L5.

He will not do any form of additional radiation to prostate at this time and tasks oncology with a pharmaceutical remedy. A radiological option may be available in the future, but it is too short a timeframe since concluding IMRT to be considered now since any damage from IMRT may not appear for some time. Seems to make a certain amount of sense.

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Profile picture for mjp0512 @mjp0512

OK then...got the call back from RO. Stat MRI of lower spine ordered to provide for SBRT targeting of L5.

He will not do any form of additional radiation to prostate at this time and tasks oncology with a pharmaceutical remedy. A radiological option may be available in the future, but it is too short a timeframe since concluding IMRT to be considered now since any damage from IMRT may not appear for some time. Seems to make a certain amount of sense.

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@mjp0512

I am so glad that you got some input and explanation 😌 and the plan seems pretty straightforward which is good. You will zap that L5 (as did Jeff) 👍 - and perhaps it is better to take one step at the time. I am sure that your RO will now also "activate" the rest of a team and schedule your next app. ASAP ! It is really unconscionable that they pushed your app. so far down the road 😠. I do not understand doctors and clinics most of the time ....

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Profile picture for surftohealth88 @surftohealth88

@mjp0512

I am so glad that you got some input and explanation 😌 and the plan seems pretty straightforward which is good. You will zap that L5 (as did Jeff) 👍 - and perhaps it is better to take one step at the time. I am sure that your RO will now also "activate" the rest of a team and schedule your next app. ASAP ! It is really unconscionable that they pushed your app. so far down the road 😠. I do not understand doctors and clinics most of the time ....

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@surftohealth88 - Yea, I'm glad he's being aggressive on the L5 met. Maybe I'll be able to sleep through the night without the lower back twinges! 👍

We also had a good news/bad news discussion regarding the accelerated PSA doubling time. Good news, PET scan indicates that it is not being caused by systemic cancer spread. Bad news, the activity in L5 and prostate are themselves generating this aggressiveness.

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Profile picture for mjp0512 @mjp0512

@surftohealth88 - Yea, I'm glad he's being aggressive on the L5 met. Maybe I'll be able to sleep through the night without the lower back twinges! 👍

We also had a good news/bad news discussion regarding the accelerated PSA doubling time. Good news, PET scan indicates that it is not being caused by systemic cancer spread. Bad news, the activity in L5 and prostate are themselves generating this aggressiveness.

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@mjp0512 At least you’ll get a handle on the L5 lesion. But your prostate gland is still that active after radiation? Unreal…
Perhaps some HDR brachytherapy in the future might do the trick?
Not sure of the allowable max Gy to the gland. Best,
Phil

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Profile picture for heavyphil @heavyphil

@mjp0512 At least you’ll get a handle on the L5 lesion. But your prostate gland is still that active after radiation? Unreal…
Perhaps some HDR brachytherapy in the future might do the trick?
Not sure of the allowable max Gy to the gland. Best,
Phil

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@heavyphil Or Proton therapy, according to some sources.
Phil

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Profile picture for mjp0512 @mjp0512

@surftohealth88 - Yea, I'm glad he's being aggressive on the L5 met. Maybe I'll be able to sleep through the night without the lower back twinges! 👍

We also had a good news/bad news discussion regarding the accelerated PSA doubling time. Good news, PET scan indicates that it is not being caused by systemic cancer spread. Bad news, the activity in L5 and prostate are themselves generating this aggressiveness.

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@mjp0512
Hey mjp - I just watched this video


They said that after radiation it can take up to 3 years for all cancer to dye off and PSA bumps can happen due to inflammatory processes there. I was thinking, since you had your RT really recently maybe that is the case (knock the wood) and perhaps you have only that L5 to worry about ? Oh, I so hope that is the case 🍀 ! Maybe the blip of light on a prostate is just cancer still dying and emitting PSA due to inflammation !?

Thinking of you and sending healing vibes ✨✨

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Profile picture for surftohealth88 @surftohealth88

@mjp0512
Hey mjp - I just watched this video


They said that after radiation it can take up to 3 years for all cancer to dye off and PSA bumps can happen due to inflammatory processes there. I was thinking, since you had your RT really recently maybe that is the case (knock the wood) and perhaps you have only that L5 to worry about ? Oh, I so hope that is the case 🍀 ! Maybe the blip of light on a prostate is just cancer still dying and emitting PSA due to inflammation !?

Thinking of you and sending healing vibes ✨✨

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@surftohealth88 - Thanks Surf! It would be cool to not have to be concerned with prostate. Apparently, there's enough going on in my back to keep me occupied.

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I guess my RO wasn't kidding when he said, "Stat". Lumbar MRI ordered this morning, completed this afternoon, results posted this evening.
_____________________________________________
Impression:

Osseous metastatic disease replaces the marrow of the L5 vertebral body. More diffuse marrow heterogeneity is noted which is likely related to diffuse marrow infiltration.

No significant spinal canal stenosis is noted in the lumbar region. Please see additional comments above.

Procedure: MR LUMBAR SPINE W WO CONTRAST

History: 70-year-old patient with L5 metastatic disease.

There are 5 lumbar type vertebral bodies noted.

Findings:

Diffuse marrow replacement is identified in the L5 vertebral body. This is consistent with osseous metastatic disease. No significant epidural component is demonstrated. Diffuse heterogeneous marrow signal suspicious for marrow infiltration is noted throughout the lumbar spine and sacral region.

No compression deformities are noted. The distal spinal cord and conus is of normal signal intensity.

Broad-based disc bulges are present at all levels in the lumbar region. A superimposed central disc protrusion is noted at L2-L3. A superimposed LEFT paracentral disc protrusion is noted at L4-L5.

Moderate bilateral foraminal narrowing is noted at L5-S1.
___________________________________________________________

I'll reserve any speculation until I hear from RO other than to say, this report is no bueno. Apparently, there's a reason my back hurts.

REPLY
Profile picture for mjp0512 @mjp0512

I guess my RO wasn't kidding when he said, "Stat". Lumbar MRI ordered this morning, completed this afternoon, results posted this evening.
_____________________________________________
Impression:

Osseous metastatic disease replaces the marrow of the L5 vertebral body. More diffuse marrow heterogeneity is noted which is likely related to diffuse marrow infiltration.

No significant spinal canal stenosis is noted in the lumbar region. Please see additional comments above.

Procedure: MR LUMBAR SPINE W WO CONTRAST

History: 70-year-old patient with L5 metastatic disease.

There are 5 lumbar type vertebral bodies noted.

Findings:

Diffuse marrow replacement is identified in the L5 vertebral body. This is consistent with osseous metastatic disease. No significant epidural component is demonstrated. Diffuse heterogeneous marrow signal suspicious for marrow infiltration is noted throughout the lumbar spine and sacral region.

No compression deformities are noted. The distal spinal cord and conus is of normal signal intensity.

Broad-based disc bulges are present at all levels in the lumbar region. A superimposed central disc protrusion is noted at L2-L3. A superimposed LEFT paracentral disc protrusion is noted at L4-L5.

Moderate bilateral foraminal narrowing is noted at L5-S1.
___________________________________________________________

I'll reserve any speculation until I hear from RO other than to say, this report is no bueno. Apparently, there's a reason my back hurts.

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@mjp0512 If it is limited to L5, that can be spot radiated. My husband had metastases in L5 and that is what was done to destroy them.

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