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Anyone in this clinical trial for low-dose Tamoxifen (LoTam)?

Posted by whitehairwisdom @whitehairwisdom, Jan 13 12:24pm

https://www.clinicaltrials.gov/study/NCT06671912

Is anyone part of this clinical trial which began in Feb 2025? Curious to know if you've had any side effects and what are they?

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carolsue1234 | @carolsue1234 | 3 days ago
In reply to @jardinera25 "@jmab These studies (looks like they are available all over the US, according to initial poster's..." + (show)
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@jmab These studies (looks like they are available all over the US, according to initial poster's link!) are using 5 mg, or as some of us call it "baby Tam", but the study calls it "Lo-Tam." It's a 5 year study I think comparing it to AI's.

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@jardinera25 Seems my oncologist is pretending not to have heard of this and has an automatic no can do prepared.

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jmab | @jmab | 3 days ago
In reply to @carolsue1234 "@jmab I can't believe they used to give everyone 40 mg years ago, then they reduced..." + (show)
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@jmab I can't believe they used to give everyone 40 mg years ago, then they reduced it to 20mg and now we have to be scrappy to get it low enough to tolerate it. I don't want it to come back but I want to feel good.

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@carolsue1234 oh, I didn't know that they used to prescribe 40 mgs! I can't even imagine! Yes, I agree that we often have to scream to be heard. I'm doing ok on 10 mgs...slightly more brain fog, maybe. At 72, it's hard to know of the Tam is causing issues or if it's just my age! Anyway, I'll continue with the 10 mgs because I agree with you, I don't want it to come back!

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jmab | @jmab | 2 days ago
In reply to @carolsue1234 "@jardinera25 Seems my oncologist is pretending not to have heard of this and has an automatic..." + (show)
Profile picture for carolsue1234 @carolsue1234

@jardinera25 Seems my oncologist is pretending not to have heard of this and has an automatic no can do prepared.

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@carolsue1234 I didn't give my oncologist a choice. After weighing everything (my diagnosis, risk factors, etc), I said there's no way I'm taking 20 mgs of Tamoxifen. He sighed. 😆 But he then conceded that the ongoing trials for low-dose Tam look promising & why would they be spending the time & money if they didn't think that there was a future for taking a lower dose? I've taken 10 mg of Tam since Jan. 1st.

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carolsue1234 | @carolsue1234 | 2 minutes ago

I am so glad we are speaking up and advocating for ourselves. The times are changing and we want safer better options and not one size fits all.

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