Hot Flashes 4 Years Post Single Lupron Inj

I did not experience that. We monitored my testosterone levels with every PSA test. As testosterone level dropped (remained in high-single to low-double digits), side-effects increased. (PSA remained at 0.008 for the duration.) As testosterone levels increased, all side-effects decreased, eventually going away. I no longer experienced the warm flashes.

I'd like to answer your end of post question but I'm confused.
Did you have just one Lupron shot as indicated in your title and question or a year long series of monthly shots?? (I'll assume 'monthly')
I had RALP 1/22 and started monthly Lupron shots 3/22 and last one 1/23.
Yes, I still have hot flashes. But reduced with paroxetine; similar to your venlaflaxine.
Are they "killer"? Not unless having to remove my hat and/or open my shirt and/or have beads of sweat in me (very thin) hair is consider killer.
I'm pretty sure you're not alone in this one so good luck with your search for relief!
And please pass it along if you find something helpful.

@grandpun

Evidence is building that ADT and Lupron in particular may be doing more harm than good. Both Duke and Harvard have raised these issues in recent studies. Looking back 25 years ago the statistical evidence for ADT is very weak and maybe not statistically significant. Damage done by ADT is well known.

@grandpun I had a single Lupron shot. I carry small fans when out of the house. Thank you for your reply.

Have you had your testosterone level checked? You really need to do that to find out what’s going on with it. That is probably the reason you’re having this problem, but It is very unusual for someone to have a three month shot and never had their testosterone come back too close to normal.. You don’t mention your age that could be a factor if you are in your 80s or late 70s.

When I had really bad hot flashes I had depo-provera Shots every three months and that stopped them. Oxybutynin i’ve been real good for some people to stop the hot flashes.

@jeffmarc

I have read that more than 50% of men never recover their testosterone after using Lupron and a 3-month shot typically lasts for 9 to 12 months of serious side effects. This has been my experience, yet I have friends who had essentially no side effects and others who have had the cancer spread. Everyone seems to be different.

@pesquallie

Do you have a link to this study? I'm a gleason 9(local) and just ended 18 months of Eligard and just nervous that it might be too early though my last PSA was < .01.

Thank you!!!

@pesquallie
I don’t know where you read this, but it is dead wrong. Can you quote this article? Or any limitations on the people they evaluated listed.

It is highly likely that testosterone levels will recover to normal after a short, three-month course of Lupron. While recovery time varies, typically 76% to over 90% of men see their testosterone return to normal levels (above 300 ng/dL) within 6 to 24 months after stopping. Permanent, irreversible suppression is rare with only three months of treatment, particularly in men younger than 65.

@dpayton

There are several articles but the one from Duke is most prominent.
https://corporate.dukehealth.org/news/study-solves-testosterones-paradoxical-effects-prostate-cancer

@dpayton All Eligard/Lupron (same active ingredient) does is suppress testosterone so as long as it stays down you are still getting the clinical effect. Will last at least 3 months more and may be 6-12 months (if younger recovery tends to be quicker). The 18-month course is likely to give you 24 months of suppression. Continue to check PSA & testosterone. Your body should notice significant recovery without a test (libido).