Anyone on Humira Biosimilars? Which Biosimilar is better for you?

I was taking Simlandi 40mg every week in addition to plaquenil and leuflonimide. I think it helped some but I developed a rash and horrible itching so ended up seeing dermatologist and she thought it was drug induced lupus, which can happen from TNF1 inhibitors. My Rheumatologist did lupus serum which were normal, 4 week high dose prednisone and just started Kineret injections.

@llwilliams73

Thanks for sharing. Just as a note, Leflunomide and Plaquenil can both cause rash and itching.

Leflunomide: This medicine may cause drug reaction with eosinophilia and systemic reactions (DRESS), including serious skin reactions. Check with your doctor right away if you have any blistering, peeling, or loose skin, chills, itching, joint or muscle pain, red skin lesions, often with a purple center, sores, ulcers, or white spots in the mouth or on the lips, or unusual tiredness or weakness. https://www.drugs.com/sfx/leflunomide-side-effects.html

Plaquenil: Plaquenil can cause a range of side effects, from mild symptoms like nausea and rash to serious complications such as eye damage, heart problems, and low blood sugar. https://www.drugs.com/sfx/plaquenil-side-effects.html

Biosimilars are not the same as generics but they are generally less expensive.
The FDA dot gov has a very good Biosimilars Info sheet explaining the difference.
(As a new member I’m not allowed to post links - sorry)

My spouse was on Enbrel since 2007 and was a miracle drug for his Ankylosing Spondylitis. A couple of years ago he developed Crohn’s most likely brought about from Enbrel use. He was going to be placed on Humira but it was not in his insurance formulary. The biosimilar, Hyrimoz, was in the formulary and has worked well for both autoimmune diseases.

@guffak

Thank you for sharing. Information for all readers:
https://www.bing.com/search
Hyrimoz (adalimumab-adaz) is manufactured by Sandoz, a division of Novartis.
Hyrimoz is a biosimilar to Humira (adalimumab) and is produced by Sandoz, which is a global leader in generic and biosimilar medicines. In the United States, Sandoz has entered a multi-year commercialization agreement with Cordavis, a wholly owned subsidiary of CVS Health, to distribute Hyrimoz under a private label starting in 2024. This partnership aims to expand patient access to the biosimilar and offer it at a significantly lower cost compared to Humira.
Sandoz continues to market Hyrimoz under its own label while providing patient support services, including copay assistance, and works directly with pharmacy benefit managers and payers in the U.S.. Hyrimoz is approved for multiple indications, including rheumatoid arthritis, psoriatic arthritis, juvenile idiopathic arthritis, and ulcerative colitis, reflecting its role as a TNF-blocker for autoimmune conditions.

@guffak, I noticed that you wished to post a URL to an article with your post. You will be able to add URLs to your posts in a few days. There is a brief period where new members can't post links. We do this to deter spammers and keep the community safe.

Allow me to post it for you:
- Biosimilars Info Sheet https://www.fda.gov/media/154912/download

@altabiznet yes I know that’s why I went to a Dermatologist and had Biopsies done as well.

Anyone on Humira or biosimilars have experienced pins and needles in the fingers and toes, and/or shooting nerve pain in the knees and wrists?

I did not have these neuropathy symptoms in the past, but now after re-starting Humira and after my first injection I have got this neuropathy. Is it a coincidence with my scleroderma progression, or a side effect? Any thoughts are appreciated.