Vitamin K: High Doses of MK-4 and MK-7 Show Promising Results

@daisy17 - I totally agree. I have summarized my research thus far & presented an outline for my adult daughters. At least their generation can be proactive (hormones, supplements, nutrition, exercise) before any stupid DEXA scan results in a powerful drug recommendation. My 51-yr old daughter has already requested an early DEXA scan due to my severe OP rating. No questions asked--her insurance covered it no hesitation.

@singingbones I found out through bloodwork that my severe OP results from parathyroid issues. I'm working with an endocrinologist to help take care of that. I also have thyroid issues that started over 35 years ago (before menopause) and was never told that I should start taking calcium supplements at that time.

@daisy17 - and there are so many factors involved (as you've just illustrated). None of this has a cookie-cutter response. And then when we attempt to research the HRT piece that we were talked out of, it's even messier--UGH!

@daisy17 - I reluctantly agreed to take the Evenity drug injections (so unlike me not to do more research). I just asked my new best friend AI about taking the Japanese recommended amts of MK-4 while taking this drug. I already take MK-7 and assumed it would be fine since it's just another form of Vit K. My concern was that the MK-4 is a therapeutic dose if taken as prescribed: 15mg 3x day. AI said there would be no issues w/taking both.

I plan to post this on the Inspire forum, too, as the Vit K conversation has been pretty robust there as well.

What I eat as food and what I take as supplements, tricky mix. Had Reclast infusion last month. No longer on GERD meds. Conflict between more calcium intensive foods vs Acid Reflux? Suggestions?

@mominal761 Are you saying that calcium pills give you GERD? You could try Seen Calcium Chews, which are small chewables that are 100% food based. Each chew contains 500mg calcium, 400IU Vitamin D, plus small amounts of phosphorus and magnesium. The ingredients are organic dates, milk minerals, almonds, milk protein and organic Vitamin D2 mushroom powder. The recommended dose is 1 chew a day. I also take 1/2 dose of a pill form of calcium.

They are available to purchase from their website: https://www.seennutrition.com/
They are kind of expensive. 30 chews cost $35.00 or $29.75 on auto delivery. 90 chews cost $105.00 or $89.25 on auto delivery.

@singingbones I like AI Assist too and here's two answers I got.

First when asking about MK-4 in general: "There are no known interactions between MK-4 supplements and Evenity, but it's always best to consult your doctor or pharmacist before starting any new supplements while on medication."

Then when asking specifically about high doses of MK-4: "High doses of MK-4 supplements may not be recommended while on Evenity, as there could be potential interactions or effects on bone health that are not fully understood. It's best to consult with your doctor or pharmacist before combining these treatments."

I hope you get some answers.

@daisy17 - just minutes ago I found the same AI Assist response! Thank you for chasing this a bit w/me. I persisted a bit w/my questions to AI and he/she/it agreed that taking a low dose of MK-4 at 5mg/day would be a safer approach while on Evenity:

Rationale: MK‑4 5 mg/day can reduce undercarboxylated osteocalcin (biochemical benefit) and is far below the 45 mg/day clinical dose that showed fracture reductions; combined with MK‑7 it gives steady K2 coverage while avoiding high‑dose MK‑4 immediately after Evenity.
Timing: You can start MK‑7 (100 mcg once daily with a meal) now. Begin MK‑4 5 mg once daily during or immediately after finishing Evenity—no known interaction with romosozumab.

Again, thank you!

@daisy17

This may have already been pointed out, but all that additional Calcium needs Vitamin K to get to your bones, instead of just remaining in your bloodstream. I'm sorry you were not informed of your thyroid issues. Neither was I, and it indicates poor follow up.

Thank you for the article link and also mentioning the Life Extension source. I had checked LE but missed that they had the Mega dose of K2 available. I'll have to think about whether the lose dose or high dose is a better plan but I'm starting with the 45mg.