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Vitamin K: High Doses of MK-4 and MK-7 Show Promising Results
Osteoporosis & Bone Health | Last Active: 5 days ago | Replies (46)Comment receiving replies
@singingbones I like AI Assist too and here's two answers I got.
First when asking about MK-4 in general: "There are no known interactions between MK-4 supplements and Evenity, but it's always best to consult your doctor or pharmacist before starting any new supplements while on medication."
Then when asking specifically about high doses of MK-4: "High doses of MK-4 supplements may not be recommended while on Evenity, as there could be potential interactions or effects on bone health that are not fully understood. It's best to consult with your doctor or pharmacist before combining these treatments."
I hope you get some answers.
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@daisy17 - just minutes ago I found the same AI Assist response! Thank you for chasing this a bit w/me. I persisted a bit w/my questions to AI and he/she/it agreed that taking a low dose of MK-4 at 5mg/day would be a safer approach while on Evenity:
Rationale: MK‑4 5 mg/day can reduce undercarboxylated osteocalcin (biochemical benefit) and is far below the 45 mg/day clinical dose that showed fracture reductions; combined with MK‑7 it gives steady K2 coverage while avoiding high‑dose MK‑4 immediately after Evenity.
Timing: You can start MK‑7 (100 mcg once daily with a meal) now. Begin MK‑4 5 mg once daily during or immediately after finishing Evenity—no known interaction with romosozumab.
Again, thank you!