Has anyone experienced fatigue after taking losartan for years?

Posted by carolinlv @carolinlv, Sep 6, 2024

I’ve taken this medication for several years without incident and suddenly over the last months, I don’t have the energy to do anything. I wake up weak and tired, with my lower legs and feet not quite right. If I try and do chores, I’m pretty much done for the day after an hour. This is completely unlike me. Over the last six months I have weaned off of both bisoprolol and rosuvastatin. I am feeling better, but the fatigue continues. Has anyone else had this happen?

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Profile picture for elsa1966 @elsa1966

i take lorsatin at night 100 mg but i wake up with my BP very high 160 over 100 and when i have breakfast it goes down

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That BP seems scary high. It sounds like lorstatin is not working for you.

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I’ve been taking 25 mg of Losartan now for almost a year. For me it must be having a cumulative effect. It’s the only pill thank goodness I’m on; but the fatigue is overwhelming. I’m going to cut that little pill in half and see if the tiredness remains. I gave it a chance but cannot function feeling this overwhelming feeling of no energy…

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Profile picture for l0lag0lag0b3 @l0lag0lag0b3

Pardon me I was never aware that Losartan is dispensed in 12.5mg, I will check it out

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Profile picture for teddybear123 @teddybear123

I’ve been taking 25 mg of Losartan now for almost a year. For me it must be having a cumulative effect. It’s the only pill thank goodness I’m on; but the fatigue is overwhelming. I’m going to cut that little pill in half and see if the tiredness remains. I gave it a chance but cannot function feeling this overwhelming feeling of no energy…

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@teddybear123 I never considered that Losartan 50 mg would give me fatigue, which is particularly chronic for me as I recover ever so slowly from standard arthroscopic surgery done in April '25 to my left knee. But my legs are chronically fatigued, and I feel it a lot after a slow 45 minute AM walk with my dogs. Thanks for the heads-up! I was leaning towards stopping my statin (Crestor) rosuvastatin due to this leg fatigue thing.

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Profile picture for laughlin1947 @laughlin1947

@teddybear123 I never considered that Losartan 50 mg would give me fatigue, which is particularly chronic for me as I recover ever so slowly from standard arthroscopic surgery done in April '25 to my left knee. But my legs are chronically fatigued, and I feel it a lot after a slow 45 minute AM walk with my dogs. Thanks for the heads-up! I was leaning towards stopping my statin (Crestor) rosuvastatin due to this leg fatigue thing.

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@laughlin1947 I wouldn’t stop any of my meds before you speak to your doctor. However, statins can also affect legs. I can only speak for my own body and I’m pretty certain that the Losartan is making me very tired.

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Profile picture for teddybear123 @teddybear123

I’ve been taking 25 mg of Losartan now for almost a year. For me it must be having a cumulative effect. It’s the only pill thank goodness I’m on; but the fatigue is overwhelming. I’m going to cut that little pill in half and see if the tiredness remains. I gave it a chance but cannot function feeling this overwhelming feeling of no energy…

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@teddybear123
I've been on Irbesartan for about 10 years and though not what you're asking about it is a very similar drug and I've not had any problems with it save for easily bruising on my arms.

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Yes! I have been talking Losartan 25mg for a year. I was having fatigue at rest and limits at exercise (walking). My nurses reduced my Losartan to half (12.5mg). I have more energy now (I can walk faster). I have more Adrenaline now. However, I have to take Lasix and Potassium now to control some new symptoms (possible side effects) such as headaches and chest pressure.

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