Trimix Effectiveness

Posted by robertcukor @robertcukor, Dec 22, 2025

Why is Trimix injection so variable in effect. The same dose of the same batch at different areas of the penis gives occasionally very strong and sometimes weak erections. Does anyone have the same experience or an answer.

Interested in more discussions like this? Go to the Men's Health Support Group.

kenk1962 | @kenk1962 | Dec 23, 2025

I had been on trimix prior to my PCa adventure. I used to use a very small dose and got great results from it.

After PCa treatment I needed to use a dose that was 3X larger than before. Further, now it varies in terms of how well it works. Sometimes I get nothing from the trimix. Most times it works okay, but never as well as it worked before PCa treatment.

I think I should also point out that trimix did not work for me at all while I was on ADT. So very frustrating, especially because my urologist didn't think testosterone levels mattered for trimix effectiveness purposes. Once my testosterone returned, however, the trimix began working again.

florida11 | @florida11 | Dec 24, 2025

I never thought of the variability as being due to the medicine (other than when it aged or got warm from traveling a lot). But now that you brought it up, I do get inconsistent results. I only need 2-3 units in a 100 unit syringe. With such a small dose, it's hard to get the exact same amount each time. But even so, sometimes it lasts an hour and other times I need to use the treadmill or weights to get it down after 3-4 hours. I'll ask my doctor next time I see him. Thanks for the topic and best of luck!

71/502 | @brucerichardson | Jun 28 4:25pm

I share the same, if not identical senecio. Always a flip of a coin. Could be great or just not close enough.

haowood | @haowood | Jul 17 6:23pm

It has been interesting reading comments about Trimix and the amount of units being used but often I don't see what strengths are involved.
I began my Trimix journey with Trimix 10mcg and 15 units. Finishing the vial at 45 units. Upon the suggestion of the pharmacist and agreement of my doctor I started the next vial at 40mcg and progressed well for a while achieving a hardness of perhaps 75% whilst maintaining that level of hardness for about one hour.
Unfortunately the amount required ended up at 75 Units so once again I have been elevated to 80mcg and now begin again at 25 Units.
I would be interested in hearing from anyone else's journey regarding strength, volume or side effects of using Trimix.
cheers from DownUnder