Is tymlos or evenity better for osteoporosis

@osteopatient2026

In reply to your overly condescending post. It was inappropriate.

I did not state that Evenity does not suppress osteoclast activity. I did state that it does not so to the extent of anti-resorptives. Big difference.

@normahorn
Sorry you took it that way. Guess I didn’t word it very well. Just trying to expand upon the post…I’m sorry.❤️😥
Hope others didn’t take it that way…I’m not a doctor and giving advice other than what I read…just relating my story and knowledge. I certainly am not infallible.

I’ll stay off the forum for now…unless something comes up. I don’t need the stress. It’s been a good place to get reassurance and info. I’m back to dealing with my husbands terminal illness.
Thx to everyone for the kind help you have been to me.
Love to you all.

@norahguil
I am 73 and have been on Evenity for 4 months. Until 4 months had no problems then lower back muscle spasms set in! Would not recommend for 97 year old with prior breaks. They say it builds bones and the last month I can attest that my body is reacting (maybe building bones)!

@normahorn
Sorry you took it that way. Guess I didn’t word it very well. Just trying to expand upon the post…I’m sorry.❤️😥
Hope others didn’t take it that way…I’m not a doctor and giving advice other than what I read…just relating my story and knowledge. I certainly am not infallible.

I’ll stay off the forum for now…unless something comes up. I don’t need the stress. It’s been a good place to get reassurance and info. I’m back to dealing with my husbands terminal illness.
Thx to everyone for the kind help you have been to me.
Love to you all.

@normahorn
Evenity (romosozumab) does transiently suppress osteoclast activity.
Here’s a more clear explanation:
Evenity is a monoclonal antibody that targets sclerostin, a protein that normally inhibits bone formation.
When sclerostin is blocked:
Osteoblast activity increases → bone is built faster.
Osteoclast activity decreases → bone breakdown slows down.
So Evenity has a dual effect:
Strong anabolic (bone-building) phase during the first few months.
Mild anti-resorptive (osteoclast-suppressing) effect throughout treatment.
How much does it suppress osteoclasts?
It does not suppress osteoclasts as strongly as:
Bisphosphonates (alendronate, risedronate)
Denosumab (Prolia)
Its effect is moderate, not complete, and is part of why bone density rises so quickly the first year.
Why this matters
The osteoblast surge builds bone.
The osteoclast suppression helps retain the new bone.
After finishing Evenity, most patients go onto an anti-resorptive (usually Prolia or a bisphosphonate) to preserve gains — because osteoclast activity rebounds once Evenity stops.

@osteopatient2026

Hi,

I was not aware that it would take 18 - 24 months before we see any improvement. What if she starts the Prolia and then goes through 12 months of misery with joint pain etc before we see any improvement? My Mother is extremely sensitive to pain so I have to consider the Prolia carefully. She had a fracture and is now in a wheelchair with physio 3x a week. The thing is, unless she can stand and walk again like before there is no point putting her on the Prolia or any of these osteoporosis medications. We live in Toronto, Ontario as well.