Brinsupri follow-up

Hi! I just started Brinsupri yesterday morning and by the end of the day my nose was running. Did this happen for anyone else?

I also want to note here that a couple of years ago I started NAC (600 mg once a day) and that has really helped to thin my mucus. When I do airway clearance I have very little to cough up.

I have had exacerbations though at least 2-3 times a year for many years.

I’m not on the Brinsupri and can’t answer question, but want to welcome you to our group of helpful people.
Do you use 7% saline? That seems to have decreased my respiratory infections, though we’ll see how this winter goes.

@julieb28 I've been on it for 10 weeks and also take a daily allegra pill for my year round allergies. So my nose runs from time to time. Hard to know what causes what. Brinsupri is a medication that takes 3-6 months to experience its full benefits. Hope it helps you.

I started taking Brinsupri on 10/29/25. On 11/1/25 I had a sudden onset of chills & temp of 102. Took 2 tylenol and temp went down and I felt fine. Did not notify MD. On 11/17/25, I woke at 2 am with chills, very SOB, Oxygen at 80. Medics took me to hospital where I was treated for hypoxia & temp of 103. I recovered quickly and by 8 am, again, felt fine. I was admitted to the hospital and it was determine that I had strepococcus pneumonia. IV therapy of Cefepime for 5 days with nebulizer treatments 4xdaily. I was discharged on Levoquin 750 mg orally for 4 additonal days. Today, I am feeling well but the cough continues and I am having difficulty bringing up the sputum. Brinsupri is on hold and frankly I am afraid to restart it as with previous infections I have never run a high fever. I have resumed Duoneb following my saline nebulizer 2 times daily followed by the chest compression. (I have also done the compression mid day). My energy level is good, I feel great (except for the nagging cough). Interested if anyone else has had a URI (specific to pneumonia)

@cdward1028 It sounds like you may have been brewing something before you started Brinsupri. Pneumonia is a risk factor in bronchiectasis. Good that you were diagnosed and treated and that you now feel good. When I've had pneumonia it takes me at least 2 weeks to get back to baseline. While on Brinsupri I developed a lower respiratory infection (LRI) after dental work. Very common occurrence according to pulmonologist. Brinsupri can take 3-6 months to work.

@pammie52 I also get mine from Pantherx. They are wonderful and I can speak with their pharmacist at any time. They are extremely knowledgeable and helpful! The pharmacist I talked to explained exactly how the drug works which no one else has. So I have a clear understanding now!
I would highly recommend them!
Stellar customer service!

@winterfelllvoyager75 I would love to hear the explanation at our Brinsupri works

@scoop
Lower RI after dental or on Brinsupri is common? Many here have noticed side effects or benefits from Brinsupri far before the 3 to 6 months. I do not think they are imagining them. To me it seems the drug has alot more side effects than we had anticipated.

@winterfelllvoyager75 Is there a chance you can tell the group of how it works? My understanding is that it blocks a pathway used by neutrophils (which cause inflammation). Am I right.

@wangling My doctor just ordered Brensupri for me last week so I haven’t started it yet, but he did say that with the 25mg dose some skin cancers were reported during trials. I was very surprised at this because I hadn’t heard or read that skin cancers were a side effect of Brensupri. But that could be the reason your pharmacist warned you to avoid sun exposure. Wondering if anyone else has any knowledge about this?