Phage Therapy ( alternative of antibiotics) for MAC lung infection

Posted by helen1000 @helen1000, Nov 25, 2023

Does anyone try Phage therapy for MAC lung infection?

Currently only a few country like Belgium, Georgia and Poland are applying this for infectious disease like UTI and lung infection.

Phage therapy is a promising afresh therapy, which uses viruses to lyse bacteria responsible for the infection. Bacteriophages have been recently administered under compassionate use to a 15-year-old patient infected with M. abscessus in combination with antibiotics with excellent results.Jan 18, 2021.

I will upload more info for people interested in it. As it has no side effects, it may be a promising way to help MAC patients.

Anyone is welcomed to add any comments or input. Thank you.

Interested in more discussions like this? Go to the MAC & Bronchiectasis Support Group.

Profile picture for irenea8 @irenea8

@kathyjjb
I think I remember him saying the Phage allowed the antibiotics to penetrate and work. So in other words both were used and it was a success.

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@irenea8 You're right, all successful cases were treated by both phages and antibiotics. I did find the presentation but could not download. It's called "A Day of Discovery, Dr Charles Daly, NTM and Bronchiectasis", It's a about 2/3 through-maybe more, where he talks about the phage therapies. Super interesting.

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Profile picture for mimimary @mimimary

Phages are specific to a bacteria. Each type of bacteria needs a different phage. As far as I know, the only NTM that they have found a phage for is abscesses. They also have found phage for pseudomonas aeruginosa. I, too, hope we can all benefit from phage therapy one day, without accompanying antibiotics. UC San Diego was doing phage treatment a few years ago. Not sure if that program is still going on, but you can certainly read their website. https://idgph.ucsd.edu/research/center-innovative-phage-applications-and-therapeutics/index.html. In my opinion the pharmaceutical industry doesn’t want phages to be available. Here’s a fascinating BBC video. https://youtu.be/bmKMIP91lTE

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@mimimary
Intriguing video!
Lets hope that progress is made in the phage industry. We are well on our way here in the U.S. to running out of options with antibiotic resistant infections in the rise.

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Profile picture for mimimary @mimimary

Phages are specific to a bacteria. Each type of bacteria needs a different phage. As far as I know, the only NTM that they have found a phage for is abscesses. They also have found phage for pseudomonas aeruginosa. I, too, hope we can all benefit from phage therapy one day, without accompanying antibiotics. UC San Diego was doing phage treatment a few years ago. Not sure if that program is still going on, but you can certainly read their website. https://idgph.ucsd.edu/research/center-innovative-phage-applications-and-therapeutics/index.html. In my opinion the pharmaceutical industry doesn’t want phages to be available. Here’s a fascinating BBC video. https://youtu.be/bmKMIP91lTE

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@mimimary
Amazing video. Thank you for posting

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Profile picture for irenea8 @irenea8

I am very interested in Phage therapy. There is a trial going on in US. If I find the link about it I will post. I know they use it for Pseudomonas. With chronic Pseudo, Phage therapy can knock it back much like antibiotics (but not usually clear it).

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@irenea8

Do you have more info about Phage therapy. I’ve had a terrible time taking Ethambutol and Rifampin and was told to stop taking azithromycin. I’m concerned about what else is available for treatment for MAC. I’m hoping to be eligible for Arikayce but it’s very expensive. I’m discouraged and hope there is something that will help with my lung infection. .Thanks

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Profile picture for yayoek @yayoek

@irenea8

Do you have more info about Phage therapy. I’ve had a terrible time taking Ethambutol and Rifampin and was told to stop taking azithromycin. I’m concerned about what else is available for treatment for MAC. I’m hoping to be eligible for Arikayce but it’s very expensive. I’m discouraged and hope there is something that will help with my lung infection. .Thanks

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@yayoek There is an assistance fund for Arikayce where it costs very little to eligible patients. I will look later today for the phone number. Irene5

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Profile picture for yayoek @yayoek

@irenea8

Do you have more info about Phage therapy. I’ve had a terrible time taking Ethambutol and Rifampin and was told to stop taking azithromycin. I’m concerned about what else is available for treatment for MAC. I’m hoping to be eligible for Arikayce but it’s very expensive. I’m discouraged and hope there is something that will help with my lung infection. .Thanks

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@yayoek
That is an old post. I am really not up to date on Phage trials going on in USA for MAC. Did you try using AI to research any trials going on? I did a quick search and got this:

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Profile picture for irenea8 @irenea8

@yayoek
That is an old post. I am really not up to date on Phage trials going on in USA for MAC. Did you try using AI to research any trials going on? I did a quick search and got this:

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@irenea8
Thanks so much for your suggestion. I’ll check it out. I appreciate your response.

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Profile picture for irene5 Irene Estes @irene5

@yayoek There is an assistance fund for Arikayce where it costs very little to eligible patients. I will look later today for the phone number. Irene5

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@irene5
Thanks again for your suggestion. I’ve applied for Arikayce but my pulmonologist is still battling my insurance company. Arikayce said I have to exhaust all possible insurance denials before I can be considered for help.

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Profile picture for yayoek @yayoek

@irene5
Thanks again for your suggestion. I’ve applied for Arikayce but my pulmonologist is still battling my insurance company. Arikayce said I have to exhaust all possible insurance denials before I can be considered for help.

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@yayoek Goodness. When I was on it I had Medicare and United Healthcare which I still have. It was covered with those and what they didn’t pay the Arikayce Assistance Fund paid. I’ll still send you the number later today after I hopefully warm up enough to look in the basement MAC bin. It’s 22 here today. Too cold for my bones. :)Irene5

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Profile picture for irene5 Irene Estes @irene5

@yayoek Goodness. When I was on it I had Medicare and United Healthcare which I still have. It was covered with those and what they didn’t pay the Arikayce Assistance Fund paid. I’ll still send you the number later today after I hopefully warm up enough to look in the basement MAC bin. It’s 22 here today. Too cold for my bones. :)Irene5

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@irene5
Hi other Irene, Is your United Healthcare a Part D plan? If so do you know if it is the premium plan or the saver plan. I think they just have the two plans.

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