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What are treatment options for platinum-resistant ovarian cancer?
Hi, My wife was diagnosed with Stage IV High Grade Serous Ovarian Cancer in May 2024. After debulking and 7 chemotherapy sessions she had her cancer in remission in Jan 2025. First follow-up tests, CT Scan and bloodwork, CA-125 at 70 in April 2025 indicates the cancer has reoccurred. We see the GYN Oncologist tomorrow. Has anyone had any experience with platinum resistant cancer recently had new therapy drugs or clinic trails in SW Michigan to fight the reoccurrence? I’m trying to find best treatment options for my wife. Thank you.
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hi every one,
I am new here but not new for ovarian cancer ...
my fight is more then 5 years now. and each day i hope for some new drug or vaccine for ovarian cancer fighters.
My oncologist tried everything on me, my last hope was Elahere , and unfortunately it didn't work....
now my cancer growing on my lymphnodes and I can say we have no more option left...
if any one knows anything new , will be very help full. Tring for clinical trials but don't know yet...
GOD is great or science ??
thanks
aabhal. oct 24/25
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4 Reactions@aabhal71 I'd like to welcome you to Mayo Clinic Connect and to our Gynecological Cancers support group. While I did not have ovarian cancer (I was diagnosed with endometrial cancer) there are members here who share your diagnosis. Five years since your diagnosis? You are the example, really, of those of us who live with cancer while we pursue treatment options.
How are you feeling? Have you applied for clinical trials and waiting to hear if you are accepted into a trial?
@aabhal71
Did your oncologist try Enhertu?
I have never been told that there are no options left by my oncologist. I have lived with ovarian cancer for more than 15 years! I have had Caelyx since being platinum resistant. I am about to start a course of treatment with Gemcitabine. I have been told there are other drugs that I can have after that.
When I was first diagnosed a friend gave me a copy of a devotional they had read. It said that you are immortal until you have fulfilled the purpose that God created you for. I have asked God to take me home many times. He keeps saying no. I still have things to do here on earth. “His grace is sufficient for me. His power is displayed in my weakness.” Don’t trust in science. It’s not as dependable as a faithful God, who loves you.
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1 Reaction@aabhal71
Did you get your tumors tested? That can open up other treatments such as Keytruda. Maybe get a 2nd opinion from one of the large treatment hospitals or look into clinical trials. Are you a candidate for another surgery or radiation therapy?
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1 Reaction@cookercooker not yet, Elahere is her next line (3rd line), her FRa expression is 75%, which means it has very good chance or working, overall survivability on Elahere is about 17 months.
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1 Reaction@lv67 yes tumor tested, her FRa expression is 75% so next line of treatment will be Elahere.
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1 Reaction@cookercooker Enhertu might be candidate if: Confirm HER2 status of the tumor (by IHC/ISH) — ideally centrally reviewed; look for IHC 3+ (or 2+ with ISH amplification) if considering benefit from T-DXd. Data suggest the best responses in IHC 3+ tumors.
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1 Reaction@jenelleseaman You are a true warrior and inspiration!
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1 Reaction@jenelleseaman amen yes God does and He carries me through amen God bless you my dear sister in Jesus Christ 🙏🩷
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